2019, Number 1
<< Back Next >>
Cuba y Salud 2019; 14 (1)
Ethics in the neurosciences. Research with stem cells in Parkinson’s disease
Díaz HMei-Li
Language: Spanish
References: 38
Page: 73-81
PDF size: 267.61 Kb.
ABSTRACT
Objectives: to analyze the state of the art on stem cell research in Parkinson’s disease from the point of view of the ethical
dilemmas to which it is confronted.
Development: the progress of medical knowledge requires research on the causes, prevention and treatment of diseases,
for which to research is often necessary in humans. Great interest within the neurosciences has Parkinson’s disease, the
second most common neurodegenerative disease that affects mostly the elderly, with a high incidence in the world. In the
search for an effective treatment for this disease, stem cell transplantation is an idea that attracts increasing attention in
research. However, this hopeful field of study also brought great controversies from the ethical point of view.
Conclusions: Parkinson’s disease has an increasing incidence, however, there is no effective therapy that prevents or
slows the course of it. In this context, research on stem cells is a promising field that opens new hopes for the treatment
of this pathology. However, it must be accompanied by the established ethical principles that determine that the human
well-being in its entirety should be the most important thing in scientific work.
REFERENCES
Milanés-Guisado Y, Solís-Cabrera FM, Navarrete-Cortés J. Aproximaciones a la evaluación del impacto social de la ciencia, la tecnología y la innovación. ACIMED. 2010;21(2):161-83.
Nuñez Jover J. La ciencia y la tecnología como procesos sociales. Lo que la educación científica no debería olvidar. 2015 [Consultado 07-08-2018] Disponible en : https://www.oei.es/historico/salactsi/nunez00.htm.
García Palacios EM, González Galbaretae JC, López Cerezo JA, Luján JL, Martín Gordillo M, Osorio C, et al. Ciencia, Tecnología y Sociedad: una aproximación conceptual. Cuadernos de Iberoamérica. In: Organización de Estados Iberoamericanos para la Educación, la Ciencia y la Cultura, ed. 1 ed. Madrid, España 2001.
Penchaszadeh VB. Ética de las investigaciones biomédicas en un mundo globalizado. In: Acosta JR, editor. Bioética para la sustentabilidad. La Habana: Ediciones Acuario, Centro Félix Varela; 2002. p. 439-54.
Álvarez-Díaz JA. Neuroética como neurociencia de la ética. Revista de Neurología. 2013;57:374-82.
Goetz CG. The History of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies. Cold Spring Harbor Perspectives in Medicine:. 2011;1(1):a008862.
Martino G, Pluchino S, Bonfanti L, Schwartz M. Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiological reviews. 2011;91(4):1281-304.
Han M-H, Lee E-H, Koh S-H. Current Opinion on the Role of Neurogenesis in the Therapeutic Strategies for Alzheimer Disease, Parkinson Disease, and Ischemic Stroke; Considering Neuronal Voiding Function. International Neurourology Journal. 2016;20(4):276-87.
Deierborg T, Soulet, D., Roybon, L., Hall, V., y Brundin, P. Emerging restorative treatments for Parkinson’s disease. Progress in Neurobiololgy. 2008;85:407-32.
Hyun I. The bioethics of stem cell research and therapy. The Journal of Clinical Investigation. 2010;120:71-5.
Durante I, sánchez G. La ética en el área de la salud. In: Morales JA, ed. Principios de ética, bioética y conocimiento del hombre. 1ra ed. Hidalgo, México: Universidad Autónoma del Estado de Hidalgo; 2011. p. 35-54.
Pérez E, Martínez J. Fundamentos filosóficos de la ética médica. In: autores Cd, ed. Lecturas de Filosofía, Salud y Sociedad. La Habana: Editorial de Ciencias Médicas; 2000. p. 135-9.
Amaro M, González R, Rodríguez H, Moreno M, Espinosa A, Llanes E, et al. Ética médica y bioética. La Habana: Editorial de Ciencias Médicas; 2009.
Pérez M, Flores J, Singh C, Paredes G. Ética médica y bioética. Perspectiva filosófica. In: autores Cd, ed. Lecturas de Filosofía, Salud y Sociedad. La Habana: Editorial de Ciencias Médicas; 2000. p. 140-64.
Illes J, Bird S. Neuroethics: a modern context for ethics in neuroscience. Trends Neurosci. 2006;29(9):511-7.
Gorga M. Implicaciones éticas del conocimiento acerca del cerebro. Una aproximación a la neuroética. Revista Colombiana de Bioética. 2015;7(1):123-39.
Figueroa G. Las ambiciones de la neuroética: fundar científicamente la moral. Acta Bioethica. 2013;19(2):259-68.
Ramos-Zuñiga R. La neuroética como una nueva perspectiva epistemológica en neurociencias. Revista de Neurología. 2014;58:145-6.
Cash R, Wikler D, Saxena A, Capron A. Estudios de caso sobre ética de la investigación internacional en salud. 1 ed. Washington, DC.: OPS; 2014.
Vargas N, Madrigal E, Esquivel C, Esquivel J, Morales JA. Marco histórico de la ética y la bioética. In: Morales JA, ed. Principios de ética, bioética y conocimiento del hombre. 1ra ed. Hidalgo, México: Universidad Autónoma del Estado de Hidalgo; 2011. p. 21-34.
Mhyre T, Boyd J, Hamill R, Maguire-Zeiss K. Parkinson´s Disease. Subcell Biochem. 2012;65:389-455.
Rodríguez M, Rodríguez-Sabate C, Morales I, Sanchez A, Sabate M. Parkinson’s disease as a result of aging. Aging Cell. 2015;14:293-308.
Mnisterio de Salud Pública de Cuba. Anuario estadístico de salud 2016. [Consultado 07-08-2018]. Disponible en http://bvscuba. sld.cu/anuario-estadistico-de-cuba/.
Inamdar NN, Arulmozhi DK, Tandon A, Bodhankar SL. Parkinson’s disease: genetics and beyond. CurrNeuropharmacol. 2007;5(2):99-113.
Rizek P, Kumar N, Jog MS. An update on the diagnosis and treatment of Parkinson disease. CMAJ : Canadian Medical Association Journal. 2016;188(16):1157-65.
Langston JW. The promise of stem cells in Parkinson disease. Journal of Clinical Investigation. 2005;115(1):23-5.
Kimmelman J, London AJ, Ravina B, Ramsay T, Bernstein M, Fine A, et al. Launching Invasive, First-in-Human Trials against Parkinson’s Disease: Ethical Considerations. Movement Disorder. 2009;24(13):1893-901.
Ventura-Juncá P. Science and ethics: bridge to the future for regenerative medicine. International Journal of Stem Cells. 2011;4(2):79-84.
Fischbach G, Fischbach R. Stem cells: science, policy, and ethics. The Journal of Clinical Investigation. 2015;114(10):1364-70.
Liras A. Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects. Journal of Translational Medicine. 2010;8(131).
Lodi D, Iannitti T, Palmieri B. Stem cells in clinical practice: applications and warnings. Journal of Experimental & Clinical Cancer Research : CR. 2011;30(1):9-.
Master Z, McLeod M, Mendez I. Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson’s disease. Journal of Medical Ethics. 2007;33:169-73.
Gibson SA, Gao GD, McDonagh K, Shen S. Progress on stem cell research towards the treatment of Parkinson’s disease. Stem Cell Res Ther. 2012;3(2):11.
King NM, Perrin J. Ethical issues in stem cell research and therapy. Stem Cell Res Ther. 2014;5(4):85.
Ishii T, Eto K. Fetal stem cell transplantation: Past, present, and future. World Journal of Stem Cells. 2014;6(4):404-20.
Dantuma E, Merchant S, Sugaya K. Stem cells for the treatment of neurodegenerative diseases. Stem Cell Research & Therapy. 2010;1(5):37.
Ramos-Zuñiga R, González-Perez O, Macías-Ornelas A, Capilla-González V, Quiñones-Hinojosa A. Ethical Implications in the Use of Embryonic and Adult Neural Stem Cells. Stem Cells International. 2012;2012(Article ID 470949):7pages.
Nam H, Lee KH, Nam DH, Min K. Adult human neural stem cell therapeutics: Current developmental status and prospect. World Journal of Stem Cells. 2015;7(1):126-36.