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2020, Number 1

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Geroinfo 2020; 15 (1)

Intestinal microbiota and aging

Contreras AR, Cabrera RI

Language: Spanish
References: 69
Page:
PDF size: 241.60 Kb.


ABSTRACT

Evidence suggests that the intestinal microbiota is associated with inflammation and chronic health conditions in the course of aging, which could generate different forms of intervention to reduce the aging process. Other research also indicates the reduction of the diversity of the intestinal microbiota and its metabolic capacities, such as the low level of short-chain fatty acids in advanced ages, which can lead to increases in intestinal transit time. This eventuality produces an increase in the density of the fecal material by reducing the content of water and dissolved oxygen that favors the development of facultative and strict anaerobic bacteria, whose metabolism could increase proteolytic activity and thereby generate changes in the pattern of fatty acids short chain, which favor the increase in branching which could lead to effects of energy metabolism at the central level. From the set of results presented, it is suggested that the use of different means of intervention that favor the limitation of the increase in the intestinal microbiota Proteobacteria, associated with aging, could have a beneficial effect on the physiological functions that are affected during aging.


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