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2020, Number 2

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Gaceta Médica Espirituana 2020; 22 (2)

Incidence of non-alcoholic fatty liver disease

Alvarez BCR, Linares BI

Language: Spanish
References: 7
Page: 1-5
PDF size: 139.40 Kb.


Text Extraction

Non-alcoholic fatty liver disease (NAFLD) is the infiltration of fat into the hepatocyte in the absence of alcohol consumption or other secondary chronic liver diseases; It includes a spectrum of liver conditions that ranges from simple steatosis to steatohepatitis, fibrosis and even cirrhosis, appears in close relation with the metabolic syndrome and with it the increase in mortality from cardiovascular diseases and malignant diseases. NAFLD is slow but progressive in its evolution, so much so that it reaches advanced forms of liver damage in up to 30 % of cases in a period of 20 to 30 years.
Associated with the epidemic of obesity and diabetes mellitus, NAFLD has increased from 2.8 % to 46 %, also before 2010 it had already become 75 % of chronic liver diseases. (4) The incidence and worldwide prevalence of NAFLD is high globally and currently represents the most frequent chronic liver disease in western countries, with an estimated prevalence of 25 % in Europe in adults and it is estimated that approximately 25-30 % of these patients will progress to nonalcoholic steatohepatitis, representing an estimated prevalence of approximately 15 %.
In the general population of the countries of the western Asia it has been calculated between 20 % to 30 %; (1) it is estimated that in the United States the prevalence in the general population varies from 3 % to 23 %; in the Latino population the frequency of this disease evaluated by liver ultrasound was 15 % in Mexico and in Brazil among obese women 33 % (7). In Cuba, the actual prevalence of the disease is unknown; the data from the published studies of the disease come from postmortem studies or from research carried out in the general population using non-invasive diagnostic procedures. Non-alcoholic fatty liver disease (NAFLD) is a clinical condition that includes liver damage; it proceeds through different phases until it reaches cirrhosis (the final stage of the disease).


REFERENCES

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  2. Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology [Internet]. 2010 [cited 2018 Jan 15];51(1):121-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799538/

  3. Suárez González M, López Mejia VM, Eirin Rey JM, González González EL, Medina Garrido Y, Díaz Oliva SE. Enfermedad hepática grasa no alcohólica. Algunas consideraciones diagnósticas. Acta Médica del Centro [Internet]. 2017 [citado 15 Ene 2019];11(2):10-8. Disponible en: http://www.revactamedicacentro.sld.cu/index.php/amc/article/view/811/1017

  4. Cenetec-Salud. Guía de Práctica Clínica. Diagnóstico y Tratamiento de enfermedad hepática no alcohólica del adulto [Internet]. México: Cenetec-Salud; 2014. [citado 15 Ene 2019]. Disponible en: http://www.cenetec.salud.gob.mx/descargas/gpc/CatalogoMaestro/719_GPC_enfermedad_hepatica_grasa_no_alcoholica/719GER.pdf

  5. Montes Teves P. Enfermedad por hígado graso no alcohólico: una epidemia en ascenso. Revista de gastroenterología del Perú [Internet]. 2016 Jul [citado 10 de Jul 2019];36(3):195-6. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292016000300001&lng=es

  6. Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, et al. Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States. Gastroenterology [Internet]. 2015 [cited 2019 Jan 15];148(3):547-55. Available from: https://www.gastrojournal.org/article/S0016-5085(14)01474-7/pdf

  7. Sarmiento Quintero F, Botero V, D´Agostino D, Delgado Carbajal L, Dewaele Oliver MR, Guzmán C, et al. Enfermedad de hígado graso no alcohólico (EHGNA): revisión y puesta al día. Grupo de trabajo de la Sociedad Latinoamericana de Gastroenterología Hepatología y Nutrición Pediátrica (SLAGHNP). Acta Gastroenterol Latinoam [Internet]. 2016 [citado 15 Ene 2019];46(3):246-64. Disponible en: https://www.redalyc.org/pdf/1993/199347749013.pdf




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