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Revista de la Asociación Médica del Centro Médico ABC

2020, Number 3

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An Med Asoc Med Hosp ABC 2020; 65 (3)

Experience in surgery for focal cortical dysplasia in children with drug-resistant epilepsy

Terrazo-Lluch J, de Font-Réaulx E, González-Astiazarán A, Ramírez-Navarrete E, Collado-Corona MÁ, Shkurovich-Bialik P, Marhx-Bracho A, García-Navarrete R, Arch-Tirado E

Language: Spanish
References: 17
Page: 201-208
PDF size: 253.86 Kb.


ABSTRACT

Introduction: Focal cortical dysplasia is the most common histopathological diagnosis in pediatric patients with drug-resistant epilepsy requiring surgery. Objective: Analyze the experience generated in the surgical treatment of pediatric patients diagnosed with Focal cortical dysplasia in two hospital centers. Material and methods: Retrospective review of 16 patients with diagnosis of drug resistant epilepsy due to FCD that were operated between 2017 to 2019 was performed. Results: Thirteen were female, with mean age of six years (range four months to 12 years). They presented an evolution of 2.7 years (range one month to 12 years). The most frequent seizure was focal onset motor seizure in nine patients (56%). The mean seizures per month were 246 seizures with a range of 0.1 to 900. Fifteen patients required two or more antiepileptic drugs. The surgical procedures performed were electrocorticography guided or image-guided lesionectomy or both in nine patients, lobectomy in five patients and hemispherectomy in two patients. Total resection of the lesion was achieved in 12 patients (75%). After surgery, nine (56%) patients were seizure free and 11 (68%) patients have a favorable seizure outcome; with a reduction in the number of epileptic drugs. Conclusions: The early diagnosis and subsequent surgical treatment of focal cortical dysplasia entails an adequate result in the control of seizures.


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