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2006, Number 3

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Bioquimia 2006; 31 (3)

Plants as source of antineoplasic agents. Review

Vega-Avila E, Velasco-Lezama R, Jiménez-Estrada M

Language: Spanish
References: 74
Page: 97-111
PDF size: 174.76 Kb.


ABSTRACT

Plants anticancer compounds obtained have been discovered by serendipity (vincristine and vinblastine), random (camptothecin), or by systematic studies (taxol). Some of these compounds have also been isolated from plants used by different cultures to treat illnesses with cancer symptomatology. In the United States of America, the antineoplasic agents derived from plants that are clinically used as anticancer drugs, in chronological order are: vinblastine (Velban®), vincristine (Oncovin®), vinolrebine (Navelbine®), vindesine (Eldisine®), etoposide (VP-16®), teniposide (VM-26®), paclitaxel (Taxol®), docetaxel (Taxotere®), topotecan (Hycamtim®) and irinotecan (Camptosar®). China and France also include 10-hydroxycamptothecin homoharringtonine and eliptinium. There are other substances involved in clinical studies based on selective activity against cancer type as just like related molecular mechanism over their acts, how is the case of angiogenic agent combretastatin A4 phosphate. Moreover, the interest has been renewed for substances as bruceantin which clinical studies had been suspended. In the present work we emphasized the importance of plants considered as medicinal resource to obtain anticancer drugs.


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