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2004, Number s2

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Arch Cardiol Mex 2004; 74 (s2)

Changing paradigms in atherothrombosis: inflammation and neovascularization in plaque progression, rupture and regression

Fuster V, Corti R, Moreno PR

Language: English
References: 55
Page: 156-163
PDF size: 121.33 Kb.


ABSTRACT

Coronary atherothrombosis remains the most frequent cause of ischemic heart disease. Plaque rupture/erosion with superimposed thrombosis is the main cause of acute coronary syndromes and sudden cardiac death. New findings have recently introduced exciting concepts that could have major impact on the treatment of the disease. We will discuss the mechanisms that lead to the development of atherothrombosis and those responsible for the acute coronary syndromes. In particular we will give some insight in the role of arterial remodeling as well as the involvement of the media/adventitia, vasa vasorum and tissue factor in atherothrombosis. Finally, we discuss the current mechanisms involved in the process of plaque regression.


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