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Rev Mex Urol 2020; 80 (4)
Language: English
References: 63
Page: 1-19
PDF size: 308.45 Kb.
ABSTRACT
Background: Testicular pain encompasses a vast medical diagnostic field, with
numerous organ and system convergence. Acute testicular pain is a medical
emergency that requires accurate evaluation and immediate resolution, whereas
chronic testicular pain is enigmatic and requires sound knowledge of the
mechanisms of testicular pain and the differential diagnosis.
Objective: To review the causes of testicular pain and propose a new etiologic
classification consisting of 10 subgroups.
Methods: A bibliographic search was carried out utilizing Google and the National
Library of Medicine’s PubMed databases to identify original articles and
review articles (hard copy or electronic) published on testicular pain, up to
March 2020. The search included: MeSH terms: testicular disease (classification,
complications, etiology, trauma, microbiology, pathology, pathophysiology,
secondary, surgery, treatment) and vasectomy; Non-MeSH terms: acute and
chronic orchialgia, scrotalgia, orchidynia, groin pain, epididymalgia, testalgia,
chronic testicular pain, chronic scrotal pain syndrome, testicular pain syndrome,
epididymal pain syndrome, and post-vasectomy pain syndrome. The initial
search produced 625 articles, of which 143 were included in the present review.
Results: To better understand testicular pain etiology, 100 possible diagnoses
were divided into ten subgroups: infectious, neoplastic, traumatic, torsional,
vascular, immunologic, neurologic, pharmacologic, obstructive, and miscellaneous
causes. Likewise, treatment can be divided into two main groups, according
to therapeutic options: pharmacologic and non-pharmacologic, with
the latter subdivided into: noninvasive and the increasingly performed invasive
(surgical) alternatives.
Conclusions: Testicular pain should be understood as a complex pain syndrome
of enigmatic origin. Treatment success depends on the correct identification,
from hundreds of possibilities, of the cause of pain. Logical grouping of those
possibilities could aid in making the accurate etiologic identification.
REFERENCES
Waldman SD. Chapter 86 - Orchialgia. In: Waldman SD, editor. Atlas of Uncommon Pain Syndromes (Third Edition). Philadelphia: W.B. Saunders; 2014. p. 251–3. [accessed 29 Jul 2020] Available from: http://www.sciencedirect.com/ science/article/pii/B9781455709991000861
Uribe JF. Testicular Pain. In: Potts JM, editor. Genitourinary Pain And Inflammation: Diagnosis And Management. Totowa, NJ: Humana Press; 2008. p. 135–65. (Current Clinical Urology). [accessed 29 Jul 2020] Available from: https://doi.org/10.1007/978-1- 60327-126-4_10
Ergün S, Bruns T, Soyka A, Tauber R. Angioarchitecture of the human spermatic cord. Cell Tissue Res. 1997 Apr 1;288(2):391–8. doi: https://doi.org/10.1007/s004410050825
Glass JM, Watkin NA. From mutilation to medication: the history of orchidectomy. Br J Urol. 1997 Sep;80(3):373–8. doi: https://doi. org/10.1046/j.1464-410x.1997.00304.x
Marcozzi D, Suner S. The nontraumatic, acute scrotum. Emerg Med Clin North Am. 2001 Aug;19(3):547–68. doi: https://doi. org/10.1016/s0733-8627(05)70203-0
Nöske HD, Kraus SW, Altinkilic BM, Weidner W. Historical milestones regarding torsion of the scrotal organs. J Urol. 1998 Jan;159(1):13– 6. doi: https://doi.org/10.1016/s0022- 5347(01)63997-1
Granitsiotis P, Kirk D. Chronic testicular pain: an overview. Eur Urol. 2004 Apr;45(4):430–6. doi: https://doi.org/10.1016/j.eururo.2003.11.004
Quallich SA, Arslanian-Engoren C. Chronic unexplained orchialgia: a concept analysis. J Adv Nurs. 2014 Aug;70(8):1717–26. doi: https:// doi.org/10.1111/jan.12340
Aljumaily A, Al-Khazraji H, Gordon A, Lau S, Jarvi KA. Characteristics and Etiologies of Chronic Scrotal Pain: A Common but Poorly Understood Condition. Pain Res Manag. 2017;2017:3829168. doi: https://doi. org/10.1155/2017/3829168
Katz J, Rosenbloom BN, Fashler S. Chronic Pain, Psychopathology, and DSM-5 Somatic Symptom Disorder. Can J Psychiatry. 2015 Apr;60(4):160–7. doi: https://doi. org/10.1177/070674371506000402
Murnion BP. Neuropathic pain: current definition and review of drug treatment. Aust Prescr. 2018 Jun;41(3):60–3. doi: https://doi. org/10.18773/austprescr.2018.022
Tung K-W, Behera D, Biswal S. Neuropathic pain mechanisms and imaging. Semin Musculoskelet Radiol. 2015 Apr;19(2):103–11. doi: https://doi.org/10.1055/s-0035-1547371
McConaghy JR, Panchal B. Epididymitis: An Overview. Am Fam Physician. 2016 Nov 1;94(9):723–6.
Sigalos JT, Pastuszak AW. Chronic orchialgia: epidemiology, diagnosis and evaluation. Transl Androl Urol. 2017 May;6(Suppl 1):S37–43. doi: https://doi.org/10.21037/tau.2017.05.23
Engeler D (chair), Baranowski AP, Berghmans B, Borovicka, J, Cottrell AM, Dinis-Oliveira P, et al. EAU Guidelines: Chronic Pelvic Pain. 2019. [accessed 29 Jul 2020] Available from: https://uroweb.org/guideline/chronic-pelvicpain/
Prehn Douglas T. A New Sign in the Differential Diagnosis Between Torsion of the Spermatic Cord and Epididymitis. Journal of Urology. 1934 Aug 1;32(2):191–200. doi: https://doi. org/10.1016/S0022-5347(17)72348-8
Bosilkovski M, Kamiloski V, Miskova S, Balalovski D, Kotevska V, Petrovski M. Testicular infection in brucellosis: Report of 34 cases. J Microbiol Immunol Infect. 2018 Feb;51(1):82–7. doi: https://doi.org/10.1016/j. jmii.2016.02.004
Patne SCU, Das M, Katiyar R. Filarial Orchitis due to Wuchereria bancrofti Masquerading as Testicular Neoplasm. Am J Trop Med Hyg. 2016 Sep 7;95(3):497–8. doi: https://doi. org/10.4269/ajtmh.16-0038
Bharucha AE, Lee TH. Anorectal and Pelvic Pain. Mayo Clin Proc. 2016 Oct;91(10):1471–86. doi: https://doi.org/10.1016/j.mayocp.2016.08.011
Ciftci H, Savas M, Yeni E, Verit A, Topal U. Chronic Orchialgia and Associated Diseases. CUR. 2010;4(2):67–70. doi: https://doi. org/10.1159/000253415
Aljumaily A, Al-Khazraji HAJ, Gordon A, Lau S, Jarvi KA. Chronic scrotal pain may lead to reduced sexual function and interest, while sexual activity may worsen chronic scrotal pain: ‘double jeopardy’. Transl Androl Urol. 2018 Mar;7(Suppl 1):S23–8. doi: https://doi. org/10.21037/tau.2017.12.06
Ghazarian AA, Rusner C, Trabert B, Braunlin M, McGlynn KA, Stang A. Testicular cancer among US men aged 50 years and older. Cancer Epidemiol. 2018;55:68–72. doi: https://doi. org/10.1016/j.canep.2018.05.007
Pedersen MR, Rafaelsen SR, Møller H, Vedsted P, Osther PJ. Testicular microlithiasis and testicular cancer: review of the literature. Int Urol Nephrol. 2016 Jul;48(7):1079–86. doi: https://doi.org/10.1007/s11255-016-1267-2
Celigoj FA, Costabile RA. Surgery of the scrotum and seminal vesicles. In: Campbell- Walsh Urology 11th ed Philadelphia, PA: Elsevier. 2016. p. 946–66.
Chung JH, Moon HS, Choi HY, Jeong TY, Ha U-S, Han JH, et al. Inhibition of adhesion and fibrosis improves the outcome of epididymectomy as a treatment for chronic epididymitis: a multicenter, randomized controlled, singleblind study. J Urol. 2013 May;189(5):1730–4. doi: https://doi.org/10.1016/j.juro.2012.11.168
Owen RC, McCormick BJ, Figler BD, Coward RM. A review of varicocele repair for pain. Transl Androl Urol. 2017 May;6(Suppl 1):S20–9. doi: https://doi.org/10.21037/tau.2017.03.36
Horovitz D, Tjong V, Domes T, Lo K, Grober ED, Jarvi K. Vasectomy reversal provides longterm pain relief for men with the post-vasectomy pain syndrome. J Urol. 2012 Feb;187(2):613–7. doi: https://doi.org/10.1016/j.juro.2011.10.023
Sinha V, Ramasamy R. Post-vasectomy pain syndrome: diagnosis, management and treatment options. Transl Androl Urol. 2017 May;6(Suppl 1):S44–7. doi: https://doi. org/10.21037/tau.2017.05.33
Sureka SK, Srivastava A, Agarwal S, Srivastava A, An S, Singh S, et al. Prevention of Orchialgia After Left-Sided Laparoscopic Donor Nephrectomy-A Prospective Study. J Endourol. 2015 Jun;29(6):696–9. doi: https:// doi.org/10.1089/end.2014.0645
Zavras N, Siatelis A, Misiakos E, Bagias G, Papachristos V, Machairas A. Testicular Dislocation After Scrotal Trauma: A Case Report and Brief Literature Review. Urol Case Rep. 2014 May;2(3):101–4. doi: https://doi. org/10.1016/j.eucr.2014.02.004
Al-Kandari AM, Kehinde EO, Khudair S, Ibrahim H, ElSheemy MS, Shokeir AA. Intermittent Testicular Torsion in Adults: An Overlooked Clinical Condition. Med Princ Pract. 2017;26(1):30–4. doi: https://doi. org/10.1159/000450887
Boettcher M, Bergholz R, Krebs TF, Wenke K, Treszl A, Aronson DC, et al. Differentiation of epididymitis and appendix testis torsion by clinical and ultrasound signs in children. Urology. 2013 Oct;82(4):899–904. doi: https:// doi.org/10.1016/j.urology.2013.04.004
Peracha J, Morgan MD. Urological manifestations and treatment of the primary systemic vasculitides. World Journal of Clinical Urology. 2015;4(1):5–20.
Dixit A, Hague C, Bicknell S. Testicular Vasculitis: A Sonographic and Pathologic Diagnosis. Case Rep Radiol. 2017;2017:8923621. doi: https://doi.org/10.1155/2017/8923621
Park HJ, Lee SS, Park NC. Predictors of pain resolution after varicocelectomy for painful varicocele. Asian J Androl. 2011 Sep;13(5):754– 8. doi: https://doi.org/10.1038/aja.2010.87
Raghavendran M, Venugopal A, Kiran Kumar G. Thrombosed varicocele - a rare cause for acute scrotal pain: a case report. BMC Urol. 2018 May 8;18(1):34. doi: https://doi.org/10.1186/ s12894-018-0347-2
Smets T, Reichman G, Michielsen DPJ. Segmental testicular infarction: a case report. J Med Case Rep. 2017 May 18;11(1):140. doi: https://doi.org/10.1186/s13256-017-1308-1
Silva CA, Cocuzza M, Carvalho JF, Bonfá E. Diagnosis and classification of autoimmune orchitis. Autoimmun Rev. 2014 May;13(4– 5):431–4. doi: https://doi.org/10.1016/j. autrev.2014.01.024
Casarin Costa JR, Virgens AR, de Oliveira Mestre L, Dias NF, Samorano LP, Valente NYS, et al. Sweet Syndrome: Clinical Features, Histopathology, and Associations of 83 Cases. J Cutan Med Surg. 2017 Jun;21(3):211–6. doi: https://doi.org/10.1177/1203475417690719
Esposito F, Sanchez O, Siebert JN, Manzano S. Acute scrotal idiopathic edema: A misleading erythema. CJEM. 2018;20(S2):S37. doi: https:// doi.org/10.1017/cem.2017.343
Holland JM, Feldman JL, Gilbert HC. Phantom orchalgia. J Urol. 1994 Dec;152(6 Pt 2):2291– 3. doi: https://doi.org/10.1016/s0022- 5347(17)31660-9
Gozon B, Chu J, Schwartz I. Lumbosacral radiculopathic pain presenting as groin and scrotal pain: pain management with twitchobtaining intramuscular stimulation. A case report and review of literature. Electromyogr Clin Neurophysiol. 2001 Aug;41(5):315–8.
McEwen J, Meyboom RH. Testicular pain caused by mazindol. Br Med J (Clin Res Ed). 1983 Dec 10;287(6407):1763–4. doi: https:// doi.org/10.1136/bmj.287.6407.1763
Padhani AR, Lopez AJ, Revell PB, MacVicar DA. Eye and testicular pain after administration of gadopentetate dimeglumine. AJR Am J Roentgenol. 1995 Aug;165(2):484–5. doi: https://doi.org/10.2214/ajr.165.2.7618587
Cui T, Terlecki R. Prevalence of Relative Deficiencies in Testosterone and Vitamin B12 Among Patients Referred for Chronic Orchialgia: Implications for Management. Am J Mens Health. 2018;12(3):608–11. doi: https:// doi.org/10.1177/1557988316642723
Goldberg SD, Witchell SJ. Right testicular pain: unusual presentation of obstruction of the ureteropelvic junction. Can J Surg. 1988 Jul;31(4):246–7.
Nair R, Abbaraju J, Rajbabu K, Anjum F, Sriprasad S. Tubular ectasia of the rete testis: a diagnostic dilemma. Ann R Coll Surg Engl. 2008 Oct;90(7):W1-3. doi: https://doi. org/10.1308/147870808x303119
Bowen J, Bruce J. Acute testicular pain: an unusual presentation of appendicitis. Br J Surg. 1994 May;81(5):776. doi: https://doi. org/10.1002/bjs.1800810551
Sequeira A, Buffington M, Gu X, Abreo K. Testicular angina during hemodialysis: an unusual complication of ultrafiltration. Hemodial Int. 2013 Apr;17(2):323–6. doi: https://doi. org/10.1111/j.1542-4758.2012.00732.x
Davies SJ, Copping R, Kumar R. Idiopathic scrotal fat necrosis: an unusual cause of scrotal pain. BMJ Case Rep. 2018 Apr 17;2018. doi: https://doi.org/10.1136/bcr-2017-224087
Tojuola B, Layman J, Kartal I, Gudelogul A, Brahmbhatt J, Parekattil S. Chronic orchialgia: Review of treatments old and new. Indian J Urol. 2016 Mar;32(1):21–6. doi: https://doi. org/10.4103/0970-1591.173110
Ölçücü MT, Ölçücü N, Ölçücüoğlu E, Ölçücüoğlu EA, Özgök Y. Response to duloxetine and gabapentin combination of a patient who has chronical orchialgia with bilateral tubular ectasia of rete testis and multiple epididymal cysts. Turk J Urol. 2018 May;44(3):274–7. doi: https://doi.org/10.5152/tud.2017.17999
Fine PG, Rosenfeld MJ. The endocannabinoid system, cannabinoids, and pain. Rambam Maimonides Med J. 2013;4(4):e0022. doi: https://doi.org/10.5041/rmmj.10129
Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018 Sep 27;23(10). doi: https://doi. org/10.3390/molecules23102478
Botulinum Toxin for the Management of Chronic Orchialgia - Full Text View - ClinicalTrials.gov. [accessed 29 Jul 2020] Available from: https://clinicaltrials.gov/ct2/ show/NCT02058836
Lamina S, Shmaila H, Muhammed SA. Transcutaneous electrical nerve stimulation (TENS) in the symptomatic management of chronic prostatitis/chronic pelvic pain syndrome: a placebo-control randomized trial. International braz j urol. 2008 Dec;34(6):708– 14. doi: https://doi.org/10.1590/S1677- 55382008000600005
Ye Z-Q, Cai D, Lan R-Z, Du G-H, Yuan X-Y, Chen Z, et al. Biofeedback therapy for chronic pelvic pain syndrome. Asian J Androl. 2003 Jun;5(2):155–8.
Calixte N, Brahmbhatt J, Parekattil S. Genital pain: algorithm for management. Translational Andrology and Urology. 2017 Apr 14;6(2):252- 257–257. doi: https://doi.org/10.21037/ tau.2017.03.03
Chen R, Nickel JC. Acupuncture ameliorates symptoms in men with chronic prostatitis/ chronic pelvic pain syndrome. Urology. 2003 Jun;61(6):1156–9; discussion 1159. doi: https:// doi.org/10.1016/s0090-4295(03)00141-9
Calixte N, Tojuola B, Kartal I, Gudeloglu A, Hirsch M, Etafy M, et al. Targeted Robotic Assisted Microsurgical Denervation of the Spermatic Cord for the Treatment of Chronic Orchialgia or Groin Pain: A Single Center, Large Series Review. J Urol. 2018;199(4):1015–22. doi: https://doi.org/10.1016/j.juro.2017.10.030
Basal S, Ergin A, Yildirim I, Goktas S, Atim A, Sizlan A, et al. A novel treatment of chronic orchialgia. J Androl. 2012 Feb;33(1):22–6. doi: https://doi.org/10.2164/jandrol.110.010991
Lee JY, Cho KS, Lee SH, Cho HJ, Cho JM, Oh CY, et al. A comparison of epididymectomy with vasectomy reversal for the surgical treatment of postvasectomy pain syndrome. Int Urol Nephrol. 2014 Mar;46(3):531–7. doi: https://doi.org/10.1007/s11255-013-0517-9
Lowe G. Extirpative surgery for chronic orchialgia: is there a role? Transl Androl Urol. 2017 May;6(Suppl 1):S2–5. doi: https://doi. org/10.21037/tau.2017.03.37