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ISSN 1561-3070 (Electronic)

2019, Number 2

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Rev Cub Oftal 2019; 32 (2)

LASEK-mitomycin C versus PRK-mitomycin C in patients with myopia or compound myopic astigmatism

Pérez SRG, Gómez DEJ, Silva HA, Pérez HHG, Cárdenas DT, Guerra AM

Language: Spanish
References: 32
Page: 1-20
PDF size: 378.59 Kb.


ABSTRACT

Objective: Evaluate the effectiveness and safety of laser-assisted subepithelial keratectomy with mitomycin C vs. photoreactive keratectomy with mitomycin C in eyes with myopia or compound myopic astigmatism.
Methods: An experimental prospective longitudinal study was conducted at Ramón Pando Ferrer Cuban Institute of Ophthalmology from April 2016 to April 2017. Simple random sampling was used to decide on the surgical technique to be applied. Surgery was first performed on the right eye using one of the techniques, and then one week later on the left eye with the other technique. That way each patient could undergo both surgical techniques. The sample was composed of 146 eyes (73 patients) meeting the inclusion criteria.
Results: Preoperative behavior was very similar in the two groups. In neither case were differences found in the variables analyzed (uncorrected visual acuity, best corrected visual acuity, sphere, cylinder and spherical equivalent). The differences between preoperative values and those found six months after surgery in each group were statistically significant for all the variables analyzed (p= 0.000), except for best corrected visual acuity in the group of eyes treated with laser with mitomycin C (p= 0.083). Haze and epithelization defect were the two types of complications observed.
Conclusions: It was demonstrated that both surgical techniques are effective and safe.


REFERENCES

  1. Moreno R, Srura M, Nieme C. Cirugía refractiva: indicaciones, técnicas y resultados. Rev Med Clin CONDES. 2010;21(6):901-10.

  2. O'Keefe M, Kirwan C. Laser epithelial keratomileusis in 2010-a review. Clin Exp Ophthalmol. 2010;38:183-91.

  3. Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P, et al. Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology. 2016;123(5):1036-42.

  4. Foulks GN. Prolonging contact lens wear and making contact lens wear safer. Am J Ophthalmol. 2006;141(2):369-73.

  5. Li SM, Zhan S, Li SY, Peng XX, Hu J, Law HA, et al. Laser-assisted subepithelial keratectomy (LASEK) versus photorefractive keratectomy (PRK) for correction of myopia. Cochrane Database Syst Rev. 2016;2:CD009799.

  6. Camellin M. Laser epithelial keratomileusis for myopia. J Refract Surg. 2003;19(6):666-70.

  7. Zhao LQ, Zhu H, Li LM. Laser-Assisted subepithelial keratectomy versus laser in situ keratomileusis in myopia: A systematic review and meta-analysis. ISRN Ophthalmology; 2014.

  8. Autrata R, Rehurek J. Laser-assisted subepithelial keratectomy and photorefractive keratectomy for the correction of hyperopia. Results of a 2-year follow-up. J Cataract Refract Surg. 2003;29(11):2105-14.

  9. Azar DT, Ang RT, Lee JB, Kato T, Chen CC, Jain S, et al. Laser subepithelial keratomileusis: electron microscopy and visual outcomes of flap photorefractive keratectomy. Curr Opin Ophthalmol. 2001;12(4):323-8.

  10. Zhao LQ, Wei RL, Cheng JW, Li Y, Cai JP, Ma XY. Meta-analysis: clinical outcomes of laser-assisted subepithelial keratectomy and photorefractive keratectomy in myopia. Ophthalmology. 2010;117(10):1912-22.

  11. Burka JM, Bower KS, Sediq DA, Edwards JD, Stutzman RD, VanRoekel RC, et al. Endothelial cell density following surface ablations for moderate and high myopia. Inv Ophthalmol Vis Sci. 2008;ARVO E-abstract:3355.

  12. Iu LPL, Fan MCY, Chen IN, Lai JSM. Predictability and stability of laser-assisted subepithelial keratectomy with mitomycin C for the correction of high myopia. Medicine (Baltimore). 2017;96(22):e7076.

  13. Shi J, Yuan Y, Zhao S, Xu J, Guo M. Effects of differenta mitomycin C concentrations on laser-assisted subepithelial keratectomy. Exp Ther Med. 2014;7(6):1591-4.

  14. Bower KS, Coe SD, Stutzman RD, Burka JM, VanRoekel RC, Sediq DA, et al. US Army Ablation Study. comparison of PRK, MMC-PRK and LASEK in moderate to high myopia. Inv Ophthalmol Vis Sci. 2007;ARVO E-abstract:5325.

  15. Cui M, Chen XM, Lu P. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for the correction of myopia: a meta-analysis. Chin Med J (Engl). 2008;121(22):2331-5.

  16. Hashemi H, Fotouhi A, Foudazi H, Sadeghi N, Payvar S. Prospective, randomized, paired comparison of laser epithelial keratomileusis and photorefractive keratectomy for myopia less than -6.50 diopters. J Refract Surg. 2004;20(3):217-22.

  17. Eguía Martínez F, Río Torres M, Capote Cabrera A, Ríos Caso R, Hernández Silva JR, Gómez Cabrera CG. Manual de diagnóstico y tratamiento en Oftalmología. La Habana: Editorial Ciencias Médicas; 2012. p. 201-9.

  18. Kaya V, Oncel B, Sivrikaya H, Yilmaz OF. Prospective, paired comparison of laser in situ keratomileusis and laser epithelial keratomileusis for myopia less than -6.00 diopters. J Refract Surg. 2004;20(3):223-8.

  19. Kim JK, Kim SS, Lee HK, Lee IS, Seong GJ, Kim EK, et al. Laser in situ keratomileusis versus laser-assisted subepithelial keratectomy for the correction of high myopia. J Cataract Refract Surg. 2004;30(7):1405-11.

  20. Sia RK, Ryan DS, Edwards JD, Stutzman RD, Bower KS. The U.S. Army Surface Ablation Study: comparison of PRK, MMC-PRK, and LASEK in moderate to high myopia. J Refract Surg. 2014;30(4):256-64.

  21. Eliaçik M, Bayramlar H, Erdur SK, Karabela Y, Demirci G, Gülkilik İG, et al. Anterior segment optical coherence tomography evaluation of corneal epithelium healing time after 2 different surface ablation methods. Saudi Med J. 2015;36(1):67-72.

  22. Autrata R, Rehurek J. Laser-assisted subepithelial keratectomy for myopia: two-year follow-up. J Cataract Refract Surg. 2003;29(4):661-8.

  23. Ghirlando A, Gambato C, Midena E. LASEK and photorefractive keratectomy for myopia: clinical and confocal microscopy comparison. J Refract Surg. 2007;23(7):694-702.

  24. Ghanem VC, Kara-Jose N, Ghanem RC, Coral SA. Photorefractive keratectomy and butterfly laser epithelial keratomileusis: a prospective, contralateral study. J Refract Surg. 2008;24(7):671-84.

  25. Mateo Gabás J. Tratamiento del astigmatismo moderado en pacientes con cataratas [Doctorado]. Zaragosa: Universidad de Zaragoza; 2013.

  26. Huang H, Yang J, Bao H, Chen S, Xia B, Zou J. Retrospective analysis of changes in the anterior corneal surface after Q value guided LASIK and LASEK in high myopic astigmatism for 3 years. BMC Ophthalmol. 2012;12:15.

  27. Gatinel D, Malet J, Hoang-Xuan T, Azar DT. Corneal Elevation Topography: Best Fit Sphere, Elevation Distance, Asphericity, Toricity and Clinical Implications. Cornea. 2011;30(5):508-15.

  28. Steinert RF. Wound healing anomalies after excimer laser photorefractive keratectomy: correlation of clinical outcomes, corneal topography, and confocal microscopy. Trans Am Ophthalmol Soc. 1997;95:629-714.

  29. Wallau A, Campos M. Photorefractive keratectomy with mitomycin C versus LASIK in custom surgeries for myopia: a bilateral prospective randomized clinical trial. J Refract Surg. 2008;24:326-36.

  30. Morales AJ, Zadok D, Mora-Retana R, Martínez-Gama E, Robledo N, Chayet A. Intraoperative mitomycin and corneal endothelium after photorefractive keratectomy. Am J Ophthalmol. 2006;142:400-4.

  31. Shojaei A, Ramezanzadeh M, Soleyman-Jahi S, Almasi-Nasrabadi M, Rezazadeh P, Eslani M. Short-time mitomycin-C application during photorefractive keratectomy in patients with low myopia. J Cataract Refract Surg. 2013;39:97-203.

  32. Roh DS, Funderburgh JL. Impact on the corneal endothelium of mitomycin C during photorefractive keratectomy. J Refract Surg. 2009;25:894-7.




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