2005, Number 4
<< Back Next >>
Rev Odont Mex 2005; 9 (4)
Pilot study about the efficiency in the use of poly (vinylpirrolidone) collagen (clgPVP or fironiquel) in osseous regeneration in endodontic surgery
Furuzawa CCZ, García ARL, Furuzawa CJ
Language: Spanish
References: 22
Page: 191-196
PDF size: 171.71 Kb.
ABSTRACT
Poly (vinylpyrrolydone) collagen (clg-PVP or FIRONIQUEL) has different medical uses such as tissue regeneration; as well as it increases tissue formation build up to 30%, including mineralized ones. The aim of this study was to evaluate the osteogenic effect of clg-PVP on osseous defects caused by chronic dental diseases. The study included 2 groups of ten patients each. The experimental group was treated with clg-PVP on the osseous defect, while the control group had no osseous generating treatment. The effect of the drug was evaluated using a densitometer comparative analyses of X-rays before and 6 months after the surgery by two external evaluators. There was a 25% higher rate regeneration compared with the control group. The evaluator coincide that osseous regeneration in the experimental group was 83% and the absence of mineralized tissue was 20%, while in the control group the regeneration was only 55%. We can conclude that the use of clg-PVP in treating osseous defects caused by periapical diseases, accelerates osseous regeneration restoring tissular architecture.
REFERENCES
Cohen S. Vías de la pulpa. Edit. Harcaut, 5a. ed. EUA, 1999.
Chimal J, Bravo T, Krötzsch F, Díaz de León L. Implantes de Fibroquel aceleran la formación de hueso nuevo en defectos óseos inducidos experimentalmente en cráneos de rata: un estudio histológico. Rev Biomed 1997; 8: 81-8.
Chimal-Monroy J, Bravo-Ruiz T, Furuzawa-Carballeda GJ, Lira RJM, De la Cruz GJC, Almazán DA, Krötzsch Gómez FE, Arrellín RG, Díaz de León L. Collagen-PVP accelerates new bone formation of experimentally induced bone defects in rat skull and promotes the expression of osteopontin and SPARC during bone repair of rat femora fractures. Ann NY Acad SCI 1988; 857: 232-6.
Krötzsch F, Furuzawa J, Reyes R, Quiroz E, Díaz de León L. Cytokine expression is downregulated by collagen-polyvinylpyrrolidone in hypertrophic scars. J Invest Dermatol 1999; 111: 828-34.
Robinson B, Sullivan F, Bazelleca J, Schwartz S. A critical review of the kinetics and toxicology of polyvinylpyrrolidone (Povidone). Lewis Publishers, Inc. 1990.
Furuzawa-Carballeda J, Rojas E, Valverde M, Castillo I, Díaz de León L, Krötzsch-Gómez FE. Cellular and humoral responses to collagen-polyvinylpyrrolidone administered during short and long periods in humans. Can J Physiol Pharmacol 2003; 81: 1029-35.
Almazán DA, de la Cruz GJC, Lira RJM et al. Investigación experimental de la regeneración ósea en fémures de rata después de la aplicación de colágena I polimerizada: Estudio radiológico, histológico e inmunohistoquímico. Rev Mex Ortop Traum 1996; 10: 142-52.
De la Cruz J. Efecto de la clg-PVP al 1% inyectable en consolidación ósea Instituto Mexicano del Seguro Social, Hospital de Traumatología y Ortopedia de Lomas Verdes México, D.F. 1997 (Tesis, UNAM).
Pohunlová H, Adam M. Reactivity and the fate of some composite bioimplants based on collagen in connective tissue. Biomaterials 1995; 16: 67-71.
Soo Ch, Rahbar G, Moy RL. The immunogenicity of bovine collagen implants. J Dermatol Surg Oncol 1993; 19: 431-434.
Charriere G, Bejot M, Schnitzler L, Ville G, Hartmann DJ. Reactions to a bovine collagen implant. J Am Acad Dermatol 1989; 21: 1203-8.
McCoy JP, Waldinger TP, Cohen KA, Schade W, Siegle R, Hamilton TA, Swanson NA. Connective tissue diseases and bovine collagen implants. J Am Acad Dermatol 1987; 16: 315-8.
Furuzawa-Carballeda J, Alcocer-Varela J, Díaz LL. Mediators of inflammation are down-regulated meanwhile apoptosis is up-regulated in rheumatoid arthritis synovial tissue by polymerized-collagen. Clin Exp Immunol 2002; 130: 140-9.
Beard HK, Faulk WP, Conochie LB, Glynn LE. Some immunological aspects of collagen. Progr Allergy 1977; 22: 45-106.
Weiss RA. Xenografts and retroviruses. Science 1999; 285: 1221-2.
Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, Chapman LE, Lockey Ch, Onions D, Otto E. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 1999; 1236-41.
Redondo L, García CJ, Verrier HL, Vaquero C. Effect of particulate porous hydroxyapatite on osteoinduction of demineralized bone autografts in experimental reconstruction of the rat mandible. Int J Oral Maxillofac Surg 1995; 24: 445-8.
Joos U, Vogel D, Ries P. Collagen fleece as a biomaterial for mandibular defects. In: Hastings GW, Williams DF. Eds. Mechanical Properties of Biomaterials. John Wiley and Son Ltd. 1980; 515-21.
Zetman D, Berthold H. The filling up of large bond defects in the maxillary region with collagen-fleece. Schweiz Mschr Zahnheilk 1982; 9: 119-26.
Fabriger A, Krekeler G. Application possibilities of collagen for the treatment of periodontal bone pockets. Dtsch Zahnarzh ZF (German Odontologic Journal) 1980; 35: 139-141.
Bermúdez H, Nesme AW, Ruiz FL, Suárez E. Tratamiento de la pseudoartrosis de la tibia con colágena-polivinilpirrolidona. Rev Mex de Ortopedia y Traumatología 1999; 13(2): 148-151.
McCoy JP, Schade W, Siegle RJ, Waldinger TP, Vanderveen EE, Swanson NA. Characterization of the humoral immune response to bovine collagen implants. Arch Dermatol 1985; 121: 990-4.