Leal-Leyte P, Zamora-Valdés D, Méndez-Sánchez N

Language: Spanish
References: 78
Page: 206-215
PDF size: 278.65 Kb.

ABSTRACT

Introduction: SARS-CoV-2/COVID-19 pandemic has affected all healthcare areas, particularly chronic diseases. Chronic liver diseases are highly prevalent in our country and represent a major cause of overall mortality. Objective: In this invited review, we analyze the literature available at June 5, 2020 on the impact of the pandemic on liver disease and transplantation. Material and methods: We performed a PubMed search using the terms «liver», «hepatic» or «transplant» and «COVID-19» or «SARS-CoV-2» included in the title and/or abstract in the category of «Journal Articles» during the last year up to June 5, 2020. The articles were analyzed by two reviewers independently. Results: We found 276 results (abstracts), from which, 54 full manuscripts fulfilled the selection criteria. Most of the available data comes from expert recommendations or consensus. Organ donation and transplantation regulatory bodies have created algorithms to guide transplant activity during the pandemic. Donor testing for SARS-CoV-2 is highly recommended but has several weaknesses. Programs have reported diminished activity during this period. Outcomes on liver transplant recipients with COVID-19 infection are heterogenous. Conclusion: SARS-CoV-2/COVID-19 pandemic has forced transplant programs to modify their practices. The transplant community faces a difficult scenario with scant scientific evidence to guide its way and decision making in the treatment of patients with liver failure in need of a lifesaving transplant during and after the pandemic.

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