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Medicina & Laboratorio

2014, Number 09-10

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Medicina & Laboratorio 2014; 20 (09-10)

Severe transient neonatal cholestasis in a post-asphyxia prematurity: a case report

Pinos-Neira M, Mora-Espinoza BA, Gafas-González C, Bonilla-Pulgar G

Language: Spanish
References: 18
Page: 489-497
PDF size: 604.34 Kb.


ABSTRACT

Newborns have a functional and anatomical immaturity. In the liver diseases cases, this situation can trigger jaundice as the main sign and together with others extrahepatic and systemic processes can lead to cholestasis, with more severity in premature. Causes of neonatal cholestasis are diverse. Patients with negative etiological search belong to transient neonatal cholestasis group. This group is characterized by early-onset cholestasis, of unknown causes, with normalization of biochemical and clinical test results during the follow-up and the clinic history of an episode of asphyxia, sepsis, total parenteral nutrition, and others, during the neonatal period. The next clinical case is about a seriously ill newborn who was hospitalized in the neonatal intensive care unit of Clinica Santa Ana (Cuenca, Ecuador) with diagnosis of prematurity, perinatal asphyxia, severe hypoglycemia, pulmonary hemorrhage, hypertrophic cardiomyopathy with pulmonary hypertension and anemia. The neonate develops severe transient neonatal cholestasis (with high direct bilirubin values that not previously reported in the reviewed literature) with favorable treatment response and complete clinical resolution.


REFERENCES

  1. Maruy Saito A. Colestasis neonatal: enfoque diagnóstico. Rev Peru Pediatr 2005; 58 (1): 28-32.

  2. Ciocca M, Álvarez F. Colestasis neonatal transitoria. Arch Argent Pediatr 2011; 109: 163-166.

  3. Hondal Álvarez N, Silverio García C, Núñez Quintana A, Ayllón Valdés L. Colestasis del recién nacido y del lactante. Rev Cubana Pediatr 2010; 82: 49-61.

  4. TelAbility Etlocwd. La nutrición parente ral total (la alimentación total intravenosa). http://www.telability.org/handouts/TelAbilityHandoutTPNfeedsSP. pdf.

  5. Coime España G. Grado de discordancia de dos métodos diagnósticos para calcular la edad del producto al nacer con la edad estimada por ultrasonido temprano y fecha de ultima menstruación confiable Hospital “Dr. Teodoro Maldonado Carbo período 2010- 2011. Facultad de Ciencias Médicas. Vol. Especialista en Ginecología y Obstétrica. Guayaquil, Ecuador: Universidad Católica de Santiago de Guayaquil; 2011: 49.

  6. Chatburn RL. 2012. Modos de ventilación de cuidados intensivos. http://campaigns. draeger.com/evitaV300/es/assets/pdf/ es/9067655_Booklet_Nomenklatur_es_ L2.pdf

  7. León Leal MC, Viñas García M, Ibáñez Cayón F, Ruiz Prieto AJ. Taquipnea transitoria del recién nacido en el Hospital General Docente “Ciro Redondo García”: Artemisa 2009. Rev Haban Cienc Méd 2010; 9: 658-664.

  8. Tassin M, Llarena P, Laffaye F, Kaltenbach G. Déficit de proteína C en un paciente con coagulación intravascular diseminada asociada a sepsis y trombosis venosa profunda: Case report. Arch Argent Pediatr 2013; 111: e28-e30.

  9. Sirvent Ochando M, López Villodre P, Martínez Seguí MJ. Soporte nutricional y tratamiento con octreótido del quilotórax. Nutr Hosp 2010; 25: 113-119.

  10. Velasco-Benítez CA. Actualización en colestasis pediátrica, incluida colestasis neonatal. Rev Gastrohnup 2009; 11: 82-92.

  11. Fischler B, Lamireau T. Cholestasis in the newborn and infant. Clin Res Hepatol Gastroenterol 2014; 38: 263-267.

  12. Frauca Remacha E, Muñoz Bartolo G. Colestasis en el lactante In: Sociedad Española de Gastroenterología HyNPS, Asociación Española de Pediatría, eds. Protocolos diagnóstico- terapéuticos de Gastroenterología, Hepatología y Nutrición Pediátrica Madrid, España: Ergon; 2010: 177-188.

  13. Larreal Espina Y, Andrade Zambrano E, Cuevas Ruiz Y, Mendoza Rico A, del Valle Montiel A, Levy Guiffrida A, et al. Pruebas de funcionalismo hepático en pacientes con infección viral aguda. Acta Bioquím Clín Latinoam 2012; 46: 38-46.

  14. Nio M, Sasaki H, Wada M, Kazama T, Nishi K, Tanaka H. Impact of age at Kasai operation on short- and long-term outcomes of type III biliary atresia at a single institution. J Pediatr Surg 2010; 45: 2361-2363.

  15. Hsiao CH, Chang MH, Chen HL, Lee HC, Wu TC, Lin CC, et al. Universal screening for biliary atresia using an infant stool color card in Taiwan. Hepatology 2008; 47: 1233-1240.

  16. Chardot C, Carton M, Spire-Bendelac N, Le Pommelet C, Golmard JL, Auvert B. Prognosis of biliary atresia in the era of liver transplantation: French national study from 1986 to 1996. Hepatology 1999; 30: 606-611.

  17. Matsui A, Dodoriki M. Screening for biliary atresia. Lancet 1995; 345: 1181.

  18. Karrer FM, Lilly JR, Stewart BA, Hall RJ. Biliary atresia registry, 1976 to 1989. J Pediatr Surg 1990; 25: 1076-1080; discussion 1081.




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