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2019, Number 4

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Rev Cubana Invest Bioméd 2019; 38 (4)

Uric acid in endothelial dysfunction and insulin resistance in cardiovascular disease

Céspedes MEM, Rodríguez GR, Suárez CN

Language: Spanish
References: 58
Page: 1-17
PDF size: 368.54 Kb.


ABSTRACT

The determination of the concentration of uric acid is often performed in health services. Plasma uric acid levels have been associated with cardiovascular diseases, and with their risk factors. However, the relevance of this association is still controversial, which is why it is proposed to base the relationship between uric acid, oxidative stress and mechanisms involved in cardiovascular disease. The information was searched through the databases of different search engines (Medline-PubMed, Cochrane, Scielo). Hyperuricemia stimulates the production of intracellular oxidizing reactive species and the reaction of uric acid with nitric oxide is related to endothelial dysfunction and insulin resistance. Uric acid levels are associated with high blood pressure, diabetes mellitus, metabolic syndrome and cardiovascular disease. It is also considered that uric acid is an independent risk factor for cardiovascular events and a predictor of morbidity and mortality from these diseases, although intervention studies with hypouricemic or uricosuric tests are required for the analysis of the benefits that could represent modify the concentration of uric acid in blood under certain conditions.


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