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ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2019, Number 4

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Rev Cubana Hematol Inmunol Hemoter 2019; 35 (4)

Polymorphism of human leukocyte antigens in Cuban recipients of related hematopoietic stem cell transplants

Burón Hernández, Jesús Salím; de la Guardia Peña, Odalis M; Chang Monteagudo, Arturo; Morera Barrios, Luz M; García García, María de los Á; Ustariz García, Catalino

Language: Spanish
References: 33
Page: 1-14
PDF size: 654.37 Kb.


ABSTRACT

Introduction: Related hematopoietic progenitor cell (TCPH) transplantation is a curative therapeutic alternative for patients with certain types of hemopathies or immunodeficiencies, in which a recipient family member is selected as a donor. Objective: To characterize the human leukocyte antigen (HLA) system in related TCPH receptors. Methods: A descriptive and cross-sectional study was conducted in the Histocompatibility department of the Institute of Hematology and Immunology from January 2013 to December 2015. 75 HLA genes were typed using the polymerase chain reaction technique with specific sequence primers, from Low resolution to 117 patients with TCPH criteria. For the immunogenetic analysis, the Harlequin 3.5.2.2 program was used. Results: The genes HLA-A * 02, HLA-B * 35, HLA-DQB1 * 03, HLA-DRB1 * 03 and HLA-DRB1 * 04, the haplotypes of two HLA-A * 02 B * 35 loci were more frequent , HLA-DQB1 * 03 DRB1 * 04 and the extended haplotype HLA-A * 03 B * 07 DQB1 * 06 DRB1 * 15. Conclusions: The genes of the HLA system in Cuban patients related to TCPH presented frequencies similar to those described in general populations of Cuba and the world, although with distinctive characteristics in some genes and haplotypes.


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