2013, Number 07-08
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Medicina & Laboratorio 2013; 19 (07-08)
Streptococcus agalactiae in pregnant women: diagnosis and prophylaxis
López VJA, Campuzano MG
Language: Spanish
References: 219
Page: 311-336
PDF size: 921.99 Kb.
ABSTRACT
Streptococcus agalactiae, also known as group B
Streptococci, is the main bacterium that
causes early-onset invasive neonatal disease. Approximately 10% to 63% of fetuses acquire the bacteria
during birth if pregnant women have recto-vaginal colonization with group B Streptococci; around
2% of the exposed newborns develop an invasive disease, and the mortality rate is approximately 2%
to 3% in term infants, and up to 20% in premature infants. It has been shown that intrapartum antibiotics
can prevent the transmissions, and consequently it often avoids that the neonate suffers from the
disease. In fact, such practice has decreased the incidence of early-onset group B streptococcal disease
in the United States; its national incidence has declined from an estimated 1.7 cases per 1000 live
births in 1990 to 0.3 cases per 1000 live births in 2003. As consequence, screening of pregnant women
is recommended; the standard method to identify pregnant women colonized with the bacteria is the
recto-vaginal culture for group B Streptococci at 35-37 weeks of gestation. Accordingly, clinical laboratories must be prepared to offer the appropriate diagnostic techniques, and the physicians should
incorporate into their daily routine the universal screening as well as chemoprophylaxis of pregnant
women colonized
Streptococcus agalactiae. This review article includes a general overview of colonization by
S. agalactiae on pregnant women, the diagnosis of the colonization, its treatment, and
prevention of early-onset invasive neonatal disease.
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República de Colombia, Ministerio de Salud. Reso-lución número 412 de 2000 del 25 de febrero, por la cual se establecen las actividades, procedimientos e intervenciones de demanda inducida y obligatorio cumplimiento y se adoptan las normas técnicas y guías de atención para el desarrollo de las acciones de protección específica y detencción temprana y la atención de enfermedades de interés en salud pú-blica.
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