medigraphic.com

2020, Number 1

<< Back Next >>

Rev Med Inst Mex Seguro Soc 2020; 58 (1)

Association between early miscarriage and Chlamydia trachomatis infection in Aguascalientes, Mexico

Gutiérrez-Campos R, Gutiérrez-Santillán EA, Bravo-Aguirre DE, Robles-Martínez MC, Cumplido-Mier CD, Rosas-Cabral A

Language: Spanish
References: 41
Page: 21-27
PDF size: 277.19 Kb.


ABSTRACT

Background: Chlamydia trachomatis infection in women has been strongly associated with early membrane rupture and pre-term labor; however, the evidence linking Chlamydia trachomatis infection and early miscarriage is inconsistent.
Objective: To determine if there is an association between Chlamydia trachomatis infection and early abortion in a group of women from Aguascalientes, Mexico.
Material and methods: 108 early abortion product samples were analyzed using polymerase chain reaction technique, along with 42 samples that belonged to 42 patients with a normal pregnancy, in order to determine the presence of Chlamydia trachomatis. The strength of association between early abortion and Chlamydia trachomatis infection was measured with odds ratio (OR) and 95% confidence intervals (95% CI). A value of p ‹ 0.05 was considered statistically significant. Results: Chlamydia trachomatis infection was positive in 39 of 150 patients (26%), in 37 of 108 women with early abortion (34%) and in two of 42 of women with uneventful control pregnancies (4.7%) (p = 0.002). We observed a positive association between the risk of early miscarriage and Chlamydia trachomatis infection (OR = 10.42, 95% CI, 2.39-45.54, p = 0.002).
Conclusions: We found a higher frequency of Chlamydia trachomatis infection than the one previously reported in our country, and a higher risk of early abortion for Chlamydia trachomatis infection (10.42) in pregnant women, which suggests the necessity of including the molecular study of this pathogen in women in prenatal control.


REFERENCES

  1. Jeve YB, Davies W. Evidence-based management of recurrent miscarriages. J Hum Reprod Sci. 2014;7(3): 159-69.

  2. Kassebaum N, Bertozzi-Villa A, Coggeshall M, Shackelford K, Steiner C, Heuton K, et al. Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet 2014; 384:980-1004.

  3. Fernández-Cantón SB, Gutiérrez-Trujillo G, Viguri-Uribe R. La mortalidad materna y el aborto en México. Bol Med Hosp Inf Mex. 2012;69(1):77-80.

  4. Janiaux E, Farquharson RG, Christiansen OB, Exalto N. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod. 2006;21(9):2216-22.

  5. Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW. The role of infection in misscarriage. Hum Reprod Update. 2016; 22(1):116-33.

  6. Bébéar C, de Barbeyrac B. Genital chlamydia trachomatis infections. Clin Microbiol Infect. 2009;15 (1):4-10.

  7. Ammerdorffer A, Stojanov M, Greub G, Baud D. Chlamydia trachomatis and chlamydia-like bacteria: new enemies of human pregnancies. Curr Opinion Infect Dis. 2017;30(3):289296.

  8. Salari MH, Badami N. The rate of Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum in females with habitual abortion and its comparison with control group. Acta Med Iran 2002;40: 79-82.

  9. Chamani-Tabriz L, Jeddi-Tehrani M, Mosavi-Jarrahi A, Zeraati H, Ghasemi J, Asgari S, et al. [The prevalence of Chlamydia Trachomatis infection by molecular analysis of urine samples in women attending OB & GYN clinics in Tehran.] [Persian]. J Reprod Infertil. 2006;7:234-42.

  10. Ahmadi A, Khodabandehloo M, Ramazanzadeh R, Farhadifar F, Roshani D, Ghaderi E, et al. The Relationship between Chlamydia trachomatis Genital Infection and Spontaneous Abortion. J Reprod Infertil. 2016;17(2):110-6.

  11. Wilkowska-Trojniel M, Zdrodowska-Stefanow B, Ostaszewska-Puchalska I, Redźko S, Przepieść J, et al. The influence of Chlamydia trachomatis infection on spontaneous abortion. Adv Med Sci. 2009;54(1):86-90

  12. Baud D, Regan L, Greub G. Emerging role of chlamydia and chlamydia-like organisms in adverse pregnancy outcomes. Curr Opinion Infect Dis. 2008;21(1):70-6.

  13. Mårdh PA. Influence of infection with Chlamydia trachomatis on pregnancy outcome, infant health and life-long sequelae in infected offspring. Best Pract Res Clin Obstet Gynaecol. 2002;16(6):847-64.

  14. Baud D, Goy G, Jaton K, Osterheld MC, Blumer S, Borel N, et al. Role of Chlamydia trachomatis in miscarriage. Emerg Infect Dis. 2011;17(9):1630-5.

  15. Osser S, Persson K. Chlamydial antibodies in women who suffer misscarriage. Br J Obstet Gynaecol. 1996;103 (2):137-41.

  16. Rae R, Smith IW, Liston WA, Kilpatrick DC. Chlamydial serologic studies and recurrent spontaneous abortion. Am J Obstet Gynecol. 1994;170(3):782-5.

  17. Silva MJ, Florêncio GL, Gabiatti JR, Amaral RL, Eleutério Júnior J, Gonçalves AK. Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study. Brazialian J Infect Dis. 2011;15(6):533-9.

  18. Kelly-Ceja GA, Salas-Gutiérrez ML, Ríos-Castillo B, Yescas-Gómez E, Peralta-Pedrero H. Guía de Práctica Clínica: Diagnóstico y tratamiento del aborto espontáneo y manejo inicial del aborto recurrente, evidencias y recomendaciones. Secretaría de Salud, México; 2009. Disponible en http://www.cenetec.salud.gob.mx/descargas/ gpc/CatalogoMaestro/088_GPC_Abortoespyrecurrente/ ABORTO_EVR_CENETEC.pdf

  19. Patel L, Sachdev D, Nagpal P, Chaudry U, Sonkar SC, Mendiratta SL, et al. Prevalence of Chlamydia infection among women visiting a ginecologic outpatient departament: evaluation of an in-house PCR assay for detection of Chlamydia trachomatis. Ann Clin Microbiol Antimicrob. 2010; 9:24.

  20. Sachdeva P, Patel AL, Sachdev D, Ali M, Mittal A, Saluja D. Comparison of an in-house PCR assay, direct fluorescence assay and the Roche Amplicor Chlamydia trachomatis kit for detetction of C. Trachomatis. J Med Microbiol. 2009;58(7):867-73.

  21. Low N, Redmond S, Uuskula A, van Bergen J, Ward H, Andersen B, et al. Screening for genital Chlamydia infection. Cochrane Database Syst Rev, 2016;sep 13:9:CD010866.

  22. Hengel B, Jamil MS, Mein JK, Maher L, Kaldor JM, Guy RJ. Outreach for Chlamydia and gonorrhoea screening: a systematic review of strategies and outcomes. BMC Public Health. 2013;13:1040. doi 10.1186/1471-2458-13- 1040.

  23. Reid F, Oakeshott P, Kerry SR, Hay Pe, Jensen JS. Chlamydia related bacteria (Chlamydides) in early pregnancy comunity-based cohort study. Clin Microbiol Infect. 2017;23(2):119.e9-119.e13.

  24. Vázquez A, Cruz C, Vázquez R. Prevalencia de Chlamydia trachomatis en población con prácticas de riesgo, un estudio de 3 años (resumen). Enferm Infecc Microbiol. 1998;18:S40.

  25. Alvarado-Esquivel C, García-Villanueva A, Castruita- Limones DE, Cardosa-Nevárez FJ, Ruiz-Astorga R. Prevalencia de infección por Chlamydia trachomatis en prostitutas registradas de la ciudad de Durango, México. Salud Publica Mex. 2000;42(1):43-7.

  26. Guerra-Infante F, Flores-Medina S, Arteaga-Troncoso G, Zamora-Ruiz A, López-Hurtado M, Ortiz-Ibarra FJ. Risk factors and reproductive sequelae associated with Chlamydia trachomatis infection in infertile women. Salud Publica Mex. 2003;45 Supp 5;S672-80.

  27. Sánchez-Monroy V, Torres-Mata AE, Villalba-Magdaleno JD. Diagnóstico de infección por Chlamydia trachomatis mediante PCR en pacieantes que acuden a la Clínica de Especialidades de la Mujer de la Secretaría de la Defensa Nacional. Ginecol Obstet Mex. 2009;77(1):13-8.

  28. Magon T, Kluz S, Chrusciel A, Obrzut B, Skert A. The PCR assessed prevalence of Chlamydia trachomatis in aborted tissues. Med Wieku Rozwoj. 2005;9(1):43-8.

  29. Hernández M, Herrera-González N, Guerra-Infante FM. Serological evidence of infection by three species of Chlamydia in pregnant women in Mexico. Ginecol Obstet Mex. 2014;82(9):585-90.

  30. Van den Berg GF, Picavet C, Hoopman R, Lohr PA, Op de Coul EL. Chlamydia screening and prophylactic treatment in termination of pregnancy clinics in the Netherlands and Great Britain: a qualitative study. Eur J Contracept Reprod Health Care. 2016;21(6):467-73.

  31. Nwokolo DC, Dragovic B, Patel S, Tong CY, Barker G, Radcliffe K. 2015 UK national guideline for the management of infection with Chlamydia trachomatis. Int J STD AIDS. 2016;27(4):251-67.

  32. Nessa K, Waris SA, Sultan Z, Monira S, Hossain M, Nahar S, et al. Epidemiology and etiology of sexually transmited infection among hotel-based sex workers in Dhaka, Bangladesh. J Clin Microbiol. 2004;42(2):618-21.

  33. Avasthi K, Garg T, Gupta S, Grewal RK, Ram S. A study of prevalence of Chlamydia trachomatis infection in women with first trimester pregnancy losses. Indian J Pathol Microbiol. 2003;46(1):133-6.

  34. Feist A, Sydler T, Gebbers JJ, Pospischil A, Guscetti F. No association of Chlamydia with abortion. J R Soc Med. 1999;92(5):237-8.

  35. Hogan RJ, Mathews SA, Mukhopadhyay S, Summersgill JT, Timms P. Chlamydial persistence: beyond the biphasic paradigm. Infect Inmun. 2004;72(4):1843-55.

  36. Conde-Ferráez L, Martíez JR, Ayora-Talavera G, Losa MD. Human papillomavirus and Chlamydia trachomatis infection in gyneco-obstetric outpatients from a Mexican hospital. Indian J Med Microbiol. 2017;35(1):74-9.

  37. Howie SE, Horner PJ, Horne AW. Chlamydia trachomatis infection during pregnancy: known unknowns. Discover Med. 2011;12(62):57-64.

  38. Tosic-Pajic J, Seklic D, Radenkovic J, Markovic S, Cikic J, Baskic D, et al. Augmented oxidative stress in infertile women with persistent chlamydial infection. Reprod Biol. 2017;17(2):120-5.

  39. Vigil P, Tapia A, Zacharias S, Riquelme R, Salgado AM, Varletta J. First-trimester pregnancy loss and active Chlamydia trachomatis infection: correlation and ultrastructural evidence. Andrología. 2002;34(6):373-8.

  40. Lu J, Zhu L, Zhang L, Jiang J, Xie F, Huang O, et al. Abnormal expression of TRAIL receptors in decidual tissue of Chlamydia trachomatis infected rats during early pregnangy loss. Reprod Sci. 2017;24(7):1041-52.

  41. Prasad P, Singh N, Das B, Raisuddin S, Dudeja M, Rastogi S. Differential expression of circulating Th1/Th2/Th17 cytokines in serum of Chlamydia trachomatis in women undergoing incomplete spontaneous abortion. Microb Pathol. 2017;110:152-8.




2020     |     www.medigraphic.com