2020, Number S1
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Ginecol Obstet Mex 2020; 88 (S1)
Female sexual function and hormonal contraception
Palacios S, Lilue M
Language: Spanish
References: 47
Page: 178-188
PDF size: 247.22 Kb.
ABSTRACT
Female sexual function has always been in the middle of the controversy of hormonal
contraception. The specific effects of the pill on female sexuality are neither
well known nor well understood. In fact, of the thousands of scientific studies
concerning hormonal contraception, few have evaluated its impact on female
sexual function. This article examines the possible effects of combined oral hormonal
contraceptives, combined with non-oral hormonal contraceptives (patch
and ring), and hormone progestin-only (AHSP) (oral, implant, injection, IUD).
For this we have reviewed the literature in English by PubMed in the last
20 years. Most of the studies reviewed mainly focus on the determination
of hormones and sexual functioning and not on other aspects of sexuality.
To date, there are few data that justify one indication or another. Therefore, individualization,
together with clinical results, should base the creation of algorithms that can
satisfy sexual preferences and individual relationships. Sexual acceptability should be
an essential point in the prescription of contraceptives. Further studies are needed to
document the sexual acceptance of the methods for women and their partners.
REFERENCES
Rivera R, et al. The mechanism of action of hormonal contraceptives and intrauterine contraceptive devices. Am J Obstet Gynecol 1999; 181 (5 Pt 1): 1263-69. https:// doi.org/10.1016/S0002-9378(99)70120-1
De Leo V, et al. Hormonal contraceptives: pharmacology tailored to women’s health. Hum Reprod Update. 2016 Sep;22(5):634-46. https://doi.org/10.1093/humupd/ dmw016
Sitruk-Ware R. New progestagens for contraceptive use. Hum Reprod Update. 2006 Mar-Apr;12(2):169-78. https:// doi.org/10.1093/humupd/dmi046
Panzer C, et al. Impact of oral contraceptives on sex hormone-binding globulin and androgen levels: A retrospective study in women with sexual dysfunction. J Sex Med 2006; 3:104-13. 10.1111/j.1743-6109.2005.00198.x
Devineni D, et al. Pharmacokinetics and pharmacodynamics of a transdermal contraceptive patch and an oral contraceptive. J Clin Pharmacol 2007; 47: 497-509. https://doi.org/10.1177/0091270006297919
Sitruk-Ware RL, et al. Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen. Contraception 2007; 75: 430-7. https://doi.org/10.1016/j. contraception.2007.01.027
Coenen CM, et al. Changes in androgens during treatment with four low-dose contraceptives. Contraception 1996; 53: 171-6. https://doi.org/10.1016/0010-7824(96)00006-6
Burrows LJ, et al. The effects of hormonal contraceptives on female sexuality: a review. J Sex Med. 2012 Sep; 9 (9): 2213-23. https://doi.org/10.1111/j.1743- 6109.2012.02848.x
Davis SR, et al. Circulating androgen levels and selfreported sexual function in women. JAMA 2005; 294: 91-6. doi:10.1001/jama.294.1.91
Sanders SA, et al. A prospective study of the effects of oral contraceptives on sexuality and well-being and their relationship to discontinuation. Contraception 2001; 64: 51-58. https://doi.org/10.1016/S0010-7824(01)00218-9
Battaglia C, et al. Sexual behavior and oral contraception: A pilot study. J Sex Med 2012; 9: 550-7. https://doi. org/10.1111/j.1743-6109.2011.02597.x
Wallwiener CW, et al. Prevalence of sexual dysfunction and impact of contraception in female German medical students. J Sex Med 2010; 7: 2139-48. https://doi. org/10.1111/j.1743-6109.2010.01742.x
Graham CA, et al. The effects of steroidal contraceptives on the well-being and sexuality of women: A double-blind, placebo-controlled, two centre study of combined and progestogen-only methods. Contraception 1995; 52: 363-9. https://doi.org/10.1016/0010-7824(95)00226-X
McCoy NL, Matyas JR. Oral contraceptives and sexuality in university women. Arch Sex Behav 1996; 25: 73-90. https:// doi.org/10.1007/BF02437907
Sabatini R, Cagiano R. Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives. Contraception 2006; 74: 220-3. https:// doi.org/10.1016/j.contraception.2006.03.022
Greenstein A, et al. Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. J Sex Med 2007; 4: 1679-83. https://doi.org/10.1111/j.1743- 6109.2007.00621.x
Bouchard C, et al. Use of oral contraceptive pills and vulvar vestibulitis: A case control study. Am J Epidemiol 2002; 156: 254-61. https://doi.org/10.1093/aje/kwf037
Bohm-Starke N, et al. Decreased mechanical pain threshold in the vestibular mucosa of women using oral contraceptives: A contributing factor in vulvar vestibulitis? J Reprod Med 2004; 49: 888-92.
Goldstein A, et al. Can oral contraceptives cause vestibulodynia? J Sex Med 2009; 7: 1585-7. https://doi. org/10.1111/j.1743-6109.2009.01685.x
Graham CA, et al. Turning on and turning off: A focus group study of the factors that affect women’s sexual arousal. Arch Sex Behav 2004; 33: 527-38. https://doi. org/10.1023/B:ASEB.0000044737.62561.fd
Caruso S, et al. Hyperandrogenic women treated with a continuous-regimen oral contraceptive. Eur J Obstet Gynecol Reprod Biol. 2013 Dec; 171 (2): 307-10. https:// doi.org/10.1016/j.ejogrb.2013.09.039
Daniels K, et al. Current contraceptive status among women aged 15-44: United States, 2011-2013. NCHS Data Brief. 2014 Dec; (173): 1-8.
Shahnazi M, et al. Comparing the effects of the second-and third-generation oral contraceptives on sexual functioning. Iran J Nurs Midwifery Res. 2015 Jan-Feb; 20 (1): 47-55. PMID: 25709690
Battaglia C, et al. Clitoral vascularization and sexual behavior in young patients treated with drospirenone-ethinyl estradiol or contraceptive vaginal ring: a prospective, randomized, pilot study. .J Sex Med. 2014 Feb; 11 (2): 471-80. https://doi.org/10.1111/jsm.12392
Zimmerman Y, et al. Restring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: II. Clinical effects. Contraception. 2015 Feb; 91 (2): 134-42. https://doi.org/10.1016/j. contraception.2014.11.008
Tracy EE. Contraception: Menarche to Menopause. Obstet Gynecol Clin North Am. 2017 Jun; 44 (2): 143-58. doi: 10.1016/j.ogc.2017.02.001.
Galzote RM, et al. Transdermal delivery of combined hormonal contraception: a review of the current literature. Int J Womens Health. 2017 May 15; 9: 315-21. doi: 10.2147/ IJWH.S102306
Roumen FJ. Review of the combined contraceptive vaginal ring, NuvaRing. Ther Clin Risk Manag. 2008 Apr; 4 (2): 441- 51. 10.2147/tcrm.s1964
Roumen FJ, et al. The contraceptive vaginal ring, Nuva- Ring(®), a decade after its introduction. Eur J Contracept Reprod Health Care. 2012 Dec; 17 (6): 415-27. https://doi. org/10.3109/13625187.2012.713535
Terrell LR, et al. Acceptability of the vaginal contraceptive ring among adolescent women. J Pediatr Adolesc Gynecol. 2011 Aug; 24 (4): 204-10. https://doi.org/10.1016/j. jpag.2011.02.003.
Collaborative Study Group on the Desogestrel-Containing Progestogen-Only Pill. A double-blind study comparing the contraceptive efficacy, acceptability and safety of two progestogen-only pills containing desogestrel 75 μg/day and levonorgestrel 30 μ/day. Eur J Contracep Reprod Health Care. 1998; 14: 169-78. https://doi. org/10.3109/13625189809167250
Lidegaard Ø, et al. Hormonal contraception and risk of venous thromboembolism: national follow-up study. BMJ. 2009; 14: b2890. https://doi.org/10.1136/bmj.b2890
Chakhtoura Z, et al. Progestogen-only contraceptives and the risk of stroke: a metaanalysis. Stroke. 2009; 14: 1059- 62. https://doi.org/10.1161/STROKEAHA.108.538405
Schaffir J. Hormonal contraception and sexual desire: a critical review. J Sex Marital Ther. 2006; 32 (4): 305-14. https://doi.org/10.1080/00926230600666311
Palacios S, et al. Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone-only pill. Acta Obstet Gynecol Scand. 2019 Jul 18. https://doi.org/10.1111/aogs.13688
Davis SR, et al. Change to either a nonandrogenic or androgenic progestin-containing oral contraceptive preparation is associated with improved sexual function in women with oral contraceptive-associated sexual dysfunction. J Sex Med. 2013 Dec; 10 (12): 3069-79. https://doi.org/10.1111/jsm.12310
Visconti F, et al. A new long-term reversible contraception method: sexual and metabolic impact. Transl Med UniSa. 2012 Oct 11; 4: 86-9. PMID: 23905067
38. Duvan Cİ, et al. Etonogestrel contraceptive implant (Implanon): analysis of patient compliance and adverse effects in the breastfeeding period. J Turk Ger Gynecol Assoc. 2010 Sep 1; 11 (3): 141-4. 10.5152/jtgga.2010.21
Di Carlo C, et al. Impact of an implantable steroid contraceptive (etonogestrel-releasing implant) on quality of life and sexual function: a preliminary study. Gynecol Endocrinol. 2014 Jan; 30 (1): 53-6. https://doi.org/10.31 09/09513590.2013.848851
Wanyonyi SZ, et al. Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception. Contraception. 2011 Nov; 84 (5): e17-22. https://doi.org/10.1016/j.contraception.2011.05.022
4Schaffir J, et al. Patient perceptions regarding effect of gynecological surgery on sexuality. J Sex Med. 2010 Feb; 7(2 Pt 1): 826-31. https://doi.org/10.1111/j.1743- 6109.2009.01572.x
Grossman Barr N. Managing adverse effects of hormonal contraceptives. Am Fam Physician. 2010 Dec 15; 82 (12).
Schivone G, et al. Injectable contraception: updates and innovation. Curr Opin Obstet Gynecol. 2016 Dec; 28 (6): 504-9. doi: 10.1097/GCO.0000000000000329
Gorgen H, et al. Use of the Levonorgestrel-IUS in the treatment of menorrhagia: assessment of quality of life in Turkish users. Arch Gynecol Obstet. 2009 Jun; 279 (6): 835-40. https://doi.org/10.1007/s00404-008-0834-x
Bastianelli C, et al. Use of the levonorgestrel-releasing intrauterine system, quality of life and sexuality. Experience in an Italian family planning center. Contraception. 2011 Oct; 84 (4): 402-8. https://doi.org/10.1016/j.contraception. 2011.01.020
Skrzypulec V, Drosdzol A. Evaluation of quality of life and sexual functioning of women using levonorgestrelreleasing intrauterine contraceptive system--Mirena. Coll Antropol. 2008 Dec; 32 (4): 1059-68. https://doi. org/10.1080/13625180701712406
Enzlin P, et al. Sexual functioning in women using levonorgestrel-releasing intrauterine systems as compared to copper intrauterine devices. J Sex Med. 2012 Apr; 9 (4): 1065-73. https://doi.org/10.1111/j.1743- 6109.2011.02266.x