medigraphic.com
ISSN 1561-297X (Print)

2019, Number 3

<< Back Next >>

Rev Cubana Estomatol 2019; 56 (3)

Hemophilic patients: clinical and molecular considerations of interest to dentists

Rebolledo CML, Bermeo SS

Language: Spanish
References: 45
Page: 1-17
PDF size: 505.31 Kb.


ABSTRACT

Introduction: Hemophilia is a genetic disease scarcely found in dental practice. On occasion it presents as a dental emergency in face of which the professional should relate the general clinical manifestations of the disease to an appropriate semiological, paraclinical and genetic-molecular analysis to diagnose the condition and apply relevant therapies aimed at solving the patient's main concern as well as managing and controlling its complications. Objective: Describe the main general pathophysiological features and aspects of dental interest of hemophilia, as well as the diagnostic tools related to the condition from a clinical, paraclinical and genetic-molecular perspective. Methods: A bibliographic search was conducted in the databases Pubmed, Proquest, Scielo and Elsevier of papers published in English and Spanish in a period of 13 years (2005-2018), using the search terms "hemophilia A", "hemophilia B", "diagnostic criteria", "genetic", "molecular", "oral health", "clinical diagnosis". A total 50 papers were selected. Data analysis and integration: Studies have shown that hemophilia, a genetic systemic condition, may have oral manifestations and complications. This makes it important to dentists, since the disease should be diagnosed from a genetic-molecular point of view and managed in an interdisciplinary manner. Conclusions: Genetic-molecular diagnosis by geneticists implies involvement of hematologists and dentists in the management and control of the condition via interconsultation, when it comes to deciding on procedures for hemophilic patients.


REFERENCES

  1. Martínez-Rider R, Garrocho-Rangel A, Márquez-Preciado R. Dental Management of a Child with Incidentally Detected Hemophilia: Report of a Clinical Case. Case Rep Dent. 2017;2017:7429738.

  2. Mansouritorghabeh H. Clinical and laboratory approaches to hemophilia A. Iran J Med Sci. 2015:40(3);194-205.

  3. Smith JA. Hemophilia: what the oral and maxillofacial surgeon needs to know. Oral Maxillofac Surg Clin North Am. 2016;28(4):481-9.

  4. Safarpour MM, Haghpanah S, Meshksar A, Karimi M. Phenotype Report on Patients with Congenital Factor V Deficiency in Southern Iran: Recent Ten Years’ Experience. Turk J Hematol. 2017;34(3):250-3.

  5. Grandas AL. Niños con hemofilia y su atención odontológica por estomatología pediátrica. Revisión de la literatura. Univ Odontol. 2016:35(74);113-26.

  6. White GC, Rosendaal F, Aledort LM, Lusher JM, Rothschild C, Ingerslev J; Factor VIII and Factor IX Subcommittee. Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost. 2001;85(3):560.

  7. Mateus HE, Pérez AM, Mesa ML, Escobar G, Gálvez JM, Montaño JI, et al. A first description of the Colombian national registry for rare diseases. BMC Res Notes. 2017;10(1):514.

  8. Ardila DLV. Consejería genética y diagnóstico prenatal: recomendaciones y futuras perspectivas para Colombia. Rev Fac Cienc Salud UDES. 2014;1(2):125-31.

  9. Wang M, Cyhaniuk A, Cooper DL, Lyer NN. Identification of patients with congenital hemophilia in a large electronic health record database. J Blood Med. 2017; 30(8):131-9.

  10. Kumar JN, Kumar RA, Varadarajan R, Sharma N. Specialty dentistry for the hemophiliac: is there a protocol in place? Indian J Dent Res. 2007;18(2):4854.

  11. Ruiz-Bedolla E, López Martínez B, Dionisio-Abraján I. Evaluación de TP y TTP en sangre total. Rev Mex Patol Clin. 2007;54(3):136-43.

  12. Blanchette VS, Key NS, Ljung LR, Manco-Johnson MJ, van den Berg HM, Srivastava A. Definitions in hemophilia: communication from the SSC of the ISTH. J Thromb Haemost. 2014;12(11):1935-9.

  13. Ofosu FA, Freedman J, Semple JW. Plasma-derived biological medicines used to promote haemostasis. Thromb Haemost. 2008; 99(5):851-62.

  14. Peyvandi F, Jayandharan G, Chandy M, Srivastava A, Nakaya SM, Johnson MJ, et al. Genetic diagnosis of haemophilia and other inherited bleeding disorders. Haem. 2006;12(3):82-9.

  15. Bermeo SM, Silva CT, Fonseca DJ, Restrepo CM. Hemophilia: Molecular diagnosis and alternatives of treatment. Col Med (Cali). 2007;38(3):308-15.

  16. Benson G, Auerswald G, Dolan G, Duffy A, Hermans C, Ljung R, et al. Diagnosis and care of patients with mild haemophilia: practical recommendations for clinical management. Blood Transfus. 2018;16(6):535-44

  17. Michaelides K, Tuddenham EG, Turner C, Lavender B, Lavery SA. Live birth following the first mutation specific pre-implantation genetic diagnosis for haemophilia A. J Thromb Haem. 2006;95(2):373-9.

  18. Konkle BA, Huston H, Nakaya Fletcher S. Hemophilia A. GeneReviews®. Seattle (WA): Universidad de Washington; 2000.

  19. Sauna ZE, Lozier JN, Kasper CK, Yanover C, Nichols T, Howard TE. The intron-22-inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomics. Blood. 2015;125(2):223-8.

  20. Donadon I, McVey JH, Garagiola I, Branchini A, Mortarino M, Peyvandi F, et al. Clustered F8 missense mutations cause hemophilia A by combined alteration of splicing and protein biosynthesis and activity. Haematologica. 2018;103(2):344-50.

  21. Mantilla-Capacho J, Beltrán-Miranda C, Jaloma-Cruz A. Diagnóstico molecular en pacientes y portadoras de hemofilia A y B. Gac Med Mex. 2005;141(1):69-71.

  22. Khan MTM, Naz A, Ahmed J, Shamsi TS, Taj AS. Diagnosis and phenotypic assessment of Pakistani Haemophilia B carriers. Pak J Med Sc. 2017;33(3):738-42.

  23. Margaglione M, Castaman G, Morfini M, Rocino A, Santagostino E, Tagariello G, et al. The Italian AICE-Genetics hemophilia A database: results and correlation with clinical phenotype. Haematologica. 2008;93(5):722-8.

  24. Peisker A, Raschke GF, Schultze-Mosgau S. Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions. Med Oral Patol Oral Cir Bucal. 2014;19(1):e55-60.

  25. Zaliuniene R, Aleksejuniene J, Peciuliene V, Brukiene V. Dental health and disease in patients with haemophilia -a case-control study. Haem. 2014;20(3):e194-8

  26. Zaliuniene R, Peciuliene V, Brukiene V, Aleksejuniene J. Hemophilia and oral health. Stomatol. 2014;16:127-131.

  27. Gaddam KR, Nuvvula S, Nirmala S, Kamatham R. Oral health status among 6- to 12-year-old haemophilic children -an educational intervention study. Haem. 2014;20:e338-41.

  28. Peyvandi F, Garagiola I, Young G. The past and future of haemophilia: diagnosis, treatments, and its complications. Lancet. 2016;388:(10040):187-97.

  29. Coppola A, Windyga J, Tufano A, Yeung C, Di Minno MN. Treatment for preventing bleeding in people with haemophilia or other congenital bleeding disorders undergoing surgery. Cochrane Database Syst Rev. 2015:CD009961.

  30. Hsieh JT, Klein K, Batstone M. Ten-year study of postoperative complications following dental extractions in patients with inherited bleeding disorders. Int. J Oral Maxillofac Surg. 2017;46:1147-50.

  31. Shastry SP, Kaul R, Baroudi K, Umar D. Hemophilia A: Dental considerations and management. J Int Soc Prev Community Dent. 2014;4(3):S147-52.

  32. Haghighi AG, Finder RG. Systemic Disease and Bleeding Disorders for the Oral and Maxillofacial Surgeon. Oral Maxillofacial Surg Clin N Am. 2016;28:461-71.

  33. Farrkh A, Garrison E, Closmann JJ. Dental surgical management of the patient with hemophilia. General Dentistry. 2016;64(4):14-7.

  34. Kämmerer PW, Frerich B, Liese J, Schiegnitz E, Al-Nawas B. Oral surgery during therapy with anticoagulants-a systematic review. Clinical Oral Investigations. 2015;19:171-80.

  35. Smith JA. Hemophilia: what the oral and maxillofacial surgeon needs to know. Oral Maxillofacial Sur Clin North Am. 2016;28(4):481-9.

  36. Nagaveni NB, Arekal S, Poornima P, Hanagawady S, Yadav S. Dental health in children with congenital bleeding disorders in and around Davangere: A case-control study. J Ind Soc Ped Prev Dent. 2016;34(1):76-81.

  37. Hewson ID, Daly J, Hallett KB, Liberali SA, Scott CL, Spaile G, et al. Consensus statement by hospital based dentists providing dental treatment for patients with inherited bleeding disorders. Aust Dent J. 2011;56(2):221-6.

  38. Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P. Acquired hemophilia A: Updated review of evidence and treatment guidance. Am J Hematol. 2017;92:695.

  39. Givol N, Hirschhorn A, Lubetsky A, Bashari D, Kenet G. Oral surgery-associated postoperative bleeding in haemophilia patients - a tertiary centre’s two decade experience. Haemophilia. 2015;21(2):234-40.

  40. Reich W, Kriwalsky MS, Wolf HH, Schubert J. Bleeding complications after oral surgery in outpatients with compromised haemostasis: incidence and management. Oral Maxillofac Surg. 2009;13(2):73-7.

  41. Kwon AY, Huh KH, Yi WJ, Symkhampha K, Heo MS, Lee SS. Haemophilic pseudotumour in two parts of the maxilla: case report. Dentomaxillofac Radiol. 2016;45(6):20150440.

  42. Argyris PP, Anim SO, Koutlas LG. Maxillary pseudotumor as initial manifestation of von Willebrand disease, type 2: report of a rare case and literature review Oral Sur, Oral Med, Oral PathoL Oral Radiol. 2016;121(2):e27-e31.

  43. Srinivasan K, Gadodia A, Bhalla AS, Choudhury AR, Bhutia O, Gupta A, et al. Magnetic resonance imaging of mandibular hemophilic pseudotumor associated with factor IX deficiency: report of case with review of literature. J Oral Maxillofac Surg. 2011;69:1683-90.

  44. Othman NA, Sockalingam SN, Mahyuddin A. Oral health status in children and adolescents with haemophilia. Haemophilia. 2015;21(5):605-11.

  45. Hassan M. Clinical and Laboratory Approaches to Hemophilia A. Iran J Med Sci. 2015;40(3):194-205.




2020     |     www.medigraphic.com