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Revista de la Asociación Médica del Centro Médico ABC

2020, Number 1

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An Med Asoc Med Hosp ABC 2020; 65 (1)

The need for implementation of sepsis code in the ABC Medical Center

Rojas GCA, Contreras CAR, Palacios COE, Aguirre SJS

Language: Spanish
References: 57
Page: 41-50
PDF size: 501.09 Kb.


ABSTRACT

We present a review of rapid response code for sepsis. The objective is to identify areas of opportunity for the early diagnosis and treatment of patients with sepsis, as well as to propose the creation of a rapid response code for future cases of sepsis in our hospital. The implementation of a sepsis code in our hospital center would aim to improve the prognosis of patients with this disease.


REFERENCES

  1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016; 315 (8): 801-810.

  2. Bloos F, Reinhart K. Rapid diagnosis of sepsis. Virulence. 2014; 5 (1): 154-160.

  3. Vincent JL. The clinical challenge of sepsis identification and monitoring. PLoS Med. 2016; 13 (5): e1002022.

  4. Vincent JL, Brealey D, Libert N, Abidi NE, O’dwyer M, Zacharowski K et al. Rapid diagnosis of infection in the critically ill, a multicenter study of molecular detection in bloodstream infections, pneumonia, and sterile site infections. Crit Care Med. 2015; 43 (11): 2283-2291.

  5. Laupland KB, Zahar JR, Adrie C, Schwebel C, Goldgran-Toledano D, Azoulay E et al. Determinants of temperature abnormalities and influence on outcome of critical illness. Crit Care Med. 2012; 40 (1): 145-151.

  6. Öncü S. A clinical outline to fever in intensive care patients. Minerva Anestesiol. 2013; 79 (4): 408-418.

  7. Kushimoto S, Gando S, Saitoh D, Mayumi T, Ogura H, Fujishima S et al. The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis. Crit Care. 2013; 17 (6): R271.

  8. Pierrakos C, Vincent JL. Sepsis biomarkers: a review. Crit Care. 2010; 14 (1): R15.

  9. Cho SY, Choi JH. Biomarkers of sepsis. Infect Chemother. 2014; 46 (1):1-12.

  10. Vincent JL, Beumier M. Diagnostic and prognostic markers in sepsis. Expert Rev Anti Infect Ther. 2013; 11 (3): 265-275.

  11. Reinhart K, Bauer M, Riedemann NC, Hartog CS. New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev. 2012; 25 (4): 609-634.

  12. Dou YH, Du JK, Liu HL, Shong XD. The role of procalcitonin in the identification of invasive fungal infection—a systemic review and meta-analysis. Diagn Microbiol Infect Dis. 2013; 76 (4): 464-469.

  13. Bloos F. Clinical diagnosis of sepsis and the combined use of biomarkers and culture- and non-culture-based assays. Methods Mol Biol. 2015; 1237: 247-260.

  14. Dark PM, Dean P, Warhurst G. Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Crit Care. 2009; 13 (4): 217.

  15. Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med. 2003; 31 (9): 2332-2338.

  16. Bouza C, López-Cuadrado T, Saz-Parkinson Z, Amate-Blanco JM. Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006-2011). BMC Infect Dis. 2014; 14: 3863.

  17. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001; 29 (7): 1303-1310.

  18. Gaieski DF, Mikkelsen ME, Band RA, Pines JM, Massone R, Furia FF et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med. 2010; 38 (4): 1045-1053.

  19. García-López L, Grau-Cerrato S, de Frutos-Soto A, Bobillo-De Lamo F, Cítores-González R, Diez-Gutiérrez F et al. Impacto de la implantación de un Código Sepsis intrahospitalario en la prescripción de antibióticos y los resultados clínicos en una unidad de cuidados intensivos. Med Intensiva. 2017; 41 (1): 12-20.

  20. Koren G, Weiss AT, Hasin Y, Appelbaum D, Welber S, Rozenman Y et al. Prevention of myocardial damage in acute myocardial ischemia by early treatment with intravenous streptokinase. N Engl J Med. 1985; 313 (22): 1384-1389.

  21. Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018; 378 (1): 11-21.

  22. Raghavan M, Marik PE. Management of sepsis during the early “golden hours”. J Emerg Med. 2006; 31 (2): 185-199.

  23. Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017; 376 (23): 2235-2244.

  24. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992; 101 (6): 1644-1655.

  25. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Int Care Med. 2003; 29 (4): 530-538.

  26. Singer M. The new definitions of SEPSIS and SEPTIC SHOCK: What do they give us? An answer. Med Intensiva. 2017; 41 (1): 41-43.

  27. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Int Care Med. 1996; 22 (7): 707-710.

  28. Vincent JL, De Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit Care Med. 1998; 26 (11): 1793-1800.

  29. Antonelli M, Moreno R, Vincent JL, Sprung CL, Mendoca A, Passariello M et al. Application of SOFA score to trauma patients. Int Care Med. 1999; 25 (4): 389-394.

  30. Moreno R, Vincent JL, Matos R, Mendonca A, Cantraine F, Thijs L et al. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Int Care Med. 1999; 25 (7): 686-696.

  31. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315 (8): 762-774.

  32. Kaukonen KM, Bailey M, Pilcher D, Cooper DJ, Bellomo R. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med. 2015; 372 (17): 1629-1638.

  33. León-Gil C, García-Castrillo Riesgo L, Moya-Mir M, Artigas-Raventós A, Borges-Sa M, Candel-González FJ et al. Documento de Consenso (SEMES-SEMICYUC): recomendaciones del manejo diagnóstico-terapéutico inicial y multidisciplinario de la sepsis grave en los servicios de urgencias hospitalarios. Med Intensiva. 2007; 31 (7): 375-387.

  34. Chertoff J, Chisum M, Garcia B, Lascano J. Lactate kinetics in sepsis and septic shock: a review of the literature and rationale for further research. J Intensive Care. 2015; 3: 39.

  35. Fan SL, Miller NS, Lee J, Remick DG. Diagnosing sepsis–The role of laboratory medicine. Clin Chim Acta. 2016; 460: 203-210.

  36. González-Ávila G, Bello-Villalobos H. Hemocultivos simultáneos y diagnóstico de sepsis relacionada a catéter. Nutr Hosp. 2004; 19 (5): 259-262.

  37. Stamm WE, Hooton TM. Management of urinary tract infections in adults. N Engl J Med. 1993; 329 (18): 1328-1334.

  38. Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Int Care Med. 2004; 30 (4): 536-555.

  39. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM. Campaña para sobrevivir a la sepsis: recomendaciones internacionales para el tratamiento de sepsis grave y choque septicémico, 2012. CCMJ. 2013; 41 (2): 36-44.

  40. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Int Care Med. 2017; 43 (3): 304-377.

  41. Mukherjee V, Evans L. Implementation of the Surviving Sepsis Campaign guidelines. Curr Opin Crit Care. 2017; 23 (5): 412-416.

  42. Levy MM, Evans LE, Rhodes A. The surviving sepsis campaign bundle: 2018 update. Int Care Med. 2018; 44 (6): 925-928.

  43. Bochud PY, Bonten M, Marchetti O, Calandra T. Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review. Crit Care Med. 2004; 32 (11): S495-S512.

  44. Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S et al. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med. 2006; 48 (1): 28-54.

  45. Paul M, Shani V, Muchtar E, Kariv G, Robenshtok E, Leibovici L. Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother. 2010; 54 (11): 4851-4863.

  46. Vincent JL, Gerlach H. Fluid resuscitation in severe sepsis and septic shock: an evidence-based review. Crit Care Med. 2004; 32 (11): S451-S454.

  47. Malbrain ML, Van Regenmortel N, Saugel B, De Tavernier B, Van Gaal PJ, Joannes-Boyau O et al. Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy. Ann Intensive Care. 2018; 8 (1): 66.

  48. Ogbu OC, Murphy DJ, Martin GS. How to avoid fluid overload. Curr Opin Crit Care. 2015; 21 (4): 315-321.

  49. Permpikul C, Tongyoo S, Viarasilpa T, Trainarongsakul T, Chakorn T, Udompanturak S. Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER). A randomized trial. Am J Respir Crit Care Med. 2019; 199 (9): 1097-1105.

  50. Lewis T, Merchan C, Altshuler D, Papadopoulos J. Safety of the peripheral administration of vasopressor agents. J Intensive Care Med. 2019; 34 (1): 26-33.

  51. Ronco C, Grammaticopoulos S, Rosner M, De Cal M, Soni S, Lentini P et al. Oliguria, creatinine and other biomarkers of acute kidney injury. Contrib Nephrol. 2010; 164: 118-127.

  52. Teboul JL, Hamzaoui O, Monnet X. SvO2 to monitor resuscitation of septic patients: let’s just understand the basic physiology. Crit Care. 2011; 15 (6): 1005.

  53. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016; 193 (3): 259-272.

  54. Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA et al. Why don’t physicians follow clinical practice guidelines?: a framework for improvement. JAMA. 199; 282 (15): 1458-1465.

  55. Aguirre-Tejedo A, Echarte-Pazos JL, Mínguez-Masó S, Supervía-Caparrós A, Skaf-Peters E, Campodarve-Botet I. Implementación de un “Código Sepsis Grave” en un servicio de urgencias. Emergencias. 2009; 21: 255-261.

  56. Ferreras-Amez JM, Arribas-Entrala B, Sarrat-Torres MA, García-Noain A, Caudevilla-Martínez A, Colás-Oros C et al. Evaluación de los resultados antes y después de la implantación del Código Sepsis en Aragón. Emergencias. 2017; 29 (3): 154-160.

  57. Robert-Boter N, Mòdol-Deltell JM, Casas-Garcia I, Rocamora-Blanch G, Lladós-Beltran G, Carreres-Molas A. Activation of a code sepsis in the emergency department is associated with a decrease in mortality. Med Clin (Barc). 2019; 152 (7): 255-260.




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