Cholesterol and lipoprotein levels and hipercholesterolemia in adolescents of the Mexico City

Irina Elizabeth Juárez-Muñoz; María Salomé Anaya-Flórez; Juan Manuel Mejía-Aranguré; Juan Games-Eternod; Martha Sciandra-Rico; Fernando Núñez-Tinoco; Julia Rocío Herrera-Márquez; Héctor González-Sánchez; Donaji Miranda-González

2006, Number 3

Bol Med Hosp Infant Mex 2006; 63 (3)

Cholesterol and lipoprotein levels and hipercholesterolemia in adolescents of the Mexico City

Juárez-Muñoz IE, Anaya-Florez MS, Mejía-Arangure JM, Games-Eternod J, Sciandra-Rico M, Núñez-Tinoco F, Herrera-Márquez JR, González-Sánchez H, Miranda-González D

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Language: Spanish
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ABSTRACT

Introduction. To know the cholesterol and lipoprotein levels in an adolescents group in Mexico City.
Material and methods. We applied a questionnaire about family history of: myocardial infarction, hypercholesterolemia and diabetes mellitus. Cholesterol and lipoproteins measurement were performed in a group of adolescents. SPSS and EPIDAT. V3 were used for statistics.
Results. Four hundred thirty adolescents were studied, the mean age were 13 years old. We found 14% hypercholesterolemic family history, 5% coronary disease and 24.7% obesity. The mean lipid levels were: cholesterol 161.3 ±36 mg/dL, triglycerides 103 ± 63 mg/dL, low density lipoprotein 91.6 ± 58 mg/dL, very low density lipoprotein 32.4 ± 64 mg/dL and high density lipoprotein 25.34 mg/dL, there were not difference between male and female; 259 (62%) adolescents presented normal cholesterol levels, 102 (24.6%) high borderline levels and 52 (12.6%) had hypercholesterolemia.
Conclusion. The main cholesterol level found was 10% higher, frequency of high borderline cholesterol levels was 30% more and hypercholesterolemia frequency increase 40% in relation to previous reports.

REFERENCES

Chapman MJ, Wills GL, TayIaur CE. The effect of lipid rich diet on the properties and composition of lipoproteins particles from de Golgi apparatus of guinea-pig liver. J Biol Chem. 1993; 131: 177-85.
Havel T. Structure and metabolism of plasma lipoprotein. JAMA. 1986; 104: 1129-38.
Russell R. The pathogenesis of atherosclerosis. N Engl J Med. 1986; 314: 488-97.
Young SG, Linton MF. Genetic abnormalities in apolipoprotein B trends cardiovascular. Am J Med. 1991; 1: 59-65.
Consensus Conference. Lowering blood cholesterol to prevent heart disease. JAMA. 1985; 253: 2080-6.
Strong J. The natural history of coronary atherosclerosis. Am J Pathol. 1962; 40: 40-9.
Goldbourt U, Neufeld H. Genetic aspects of atherosclerosis. J Pathol. 1986; 6: 357-77.
Fredrickson DJ, Cevy RL, Lesn RS. Fat transport in lipoproteins an integrated approach to mechanisms and disorders. N Engl J Med. 1967; 276: 273-81.
Havel T. The pediatrics role in atherosclerosis prevention. J Pediatr. 1988; 45: 45-50.
Plaza P. Informe sobre colesterol en niños y adolescentes. Rev Esp Cardiol. 1991; 44: 567-85.
American Academy of Pediatrics. Committee on nutrition childhood diet and coronary heart disease. Pediatrics. 1972; 49: 305-8.
Kannel W, Castell W. Cholesterol in the prediction of atherosclerosis disease. New perspectives base in the Framingham study. Ann Intern Med. 1979; 90: 85-91.
Baranowski T, Beneson G. Dinamic change of serum lipoproteins in children during adolescent an sexual maduration. Am J Epidemiol. 1981; 113: 157-70.
American Academy of Pediatrics. Biochemical epidemiological data in the pediatrics age group. Pediatrics. 1986; 78: 349-60.
Klish WJ, Baker SS, Cochran WJ, Flores CA, Georgieff MK, Jacobson MS. Cholesterol in childhood. American Academy of Pediatrics. Pediatrics. 1998; 101: 141-7.
Cueto L. Prevención de la ateroesclerosis en México. Aspectos pediátricos de la ateroesclerosis. México: 1ª de AMPAC; 1989. p. 131-50.
Juárez MI, Rivera SJ, Mercado AJ, Sciandra RM. Perfil de lípidos en recién nacidos y sus madres. Salud Publica Mex. 1999; 125: 485-8.
Miller M, Brachurick SP, Cloey A. Normal variation of plasma concentration of lipids and apolipoproteins. Clin Chem. 1992; 38: 569-74.
Lerman Gl, Sepúlveda JA, Tapia CR, Magos LC, Cardoso SG, Zamora GJ. Cholesterol levels and prevalence of hypercholesterolemia in Mexican children and teenagers. Atherosclerosis. 1993; 103: 195-203.
Tershakovec AM, Jawad AF, Stallings VA, Cortner JA, Zemel BS, Shannon BM. Age-related changes in cardiovascular disease risk factors of hypercholesterolemic children. J Pediatr. 1998; 132: 414-20.
Fitch J, Garcia RE, Moodie DS, Secic M. Influence of cholesterol screening and nutritional counseling in reducing cholesterol levels in children. Clin Pediatr. 1997; 36: 267-72.
Kronenberg F, Lobentz E, Koning P. Effect of sample storage on the measurement of lipoprotein, apolipoprotein B and A, total and high density cholesterol and triglycerides. J Lip Res. 1992; 35: 1315-28.
Rifai N, Russell W, McNamara J. Measurement of low density 1-lipoprotein cholesterol in serum: A status report. Clin Chem. 1992; 38: 150-62.
Friedewald WT, Fredrickson DJ. Estimation of lipoprotein cholesterol in plasma without concentration of low density use ultracentrifuge. Clin Chem. 1972; 18: 449-502.
Mejía AJ, Fajardo GA, Gómez DA. El tamaño de la muestra: un enfoque práctico en la investigación clínica pediátrica. Bol Med Hosp Infant Mex. 1995; 52: 381-91.