medigraphic.com
ISSN 2007-4360 (Print)
Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2019, Number 3

<< Back Next >>

Rev Mex Periodontol 2019; 10 (3)

Herpesvirus: relationship to periodontal disease and oral implications

Guerrero Bernal, Cristian Gabriel; Tinoco Cabral, Claudia; Morales Martínez, Jesús; Gutiérrez Guerra, Alejandro; Hernández Andrade, Lucila; Gaona Bernal, Jorge; Hernández Cañaveral, Iván Isidro

Language: Spanish
References: 22
Page: 58-64
PDF size: 955.22 Kb.


ABSTRACT

Periodontitis is a chronic inflammatory disease that causes destruction of the support structures of the tooth, causing its loss. Bacterial agents organized in the form of biofilm are key in the development of Periodontitis but their presence alone cannot always explain the clinical-pathological characteristics of the disease. The evidence suggests that herpesviruses and bacteria could cooperate synergistically in the development of periodontitis, supporting an association, since an active herpesvirus infection can induce immunosuppression leading to an overgrowth of pathogenic bacteria, and potentially convert gingivitis into periodontitis or stable periodontitis in progressive disease. Some studies indicated a significantly higher risk of periodontitis accompanied by a higher prevalence of herpesvirus detection. Millions of genomic copies of human viruses can be housed in periodontal lesions, and herpesviruses are the most researched viruses in periodontology. Patients with periodontitis have elevated serum levels of antibodies against Herpesvirus and inflammatory mediators.


REFERENCES

  1. Novak N, Peng WM. Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells. British Society for Immunology. Clin Exp Immunol. 2005; 142 (3): 405-410.

  2. Slots J, Slots H. Periodontal herpesvirus morbidity and treatment. Periodontol 2000. 2019; 79 (1): 210-220.

  3. Crimi S, Fiorillo L, Bianch A, D’Amico C, Amoroso G, Gorassini F et al. Herpes virus, oral clinical signs and QoL: systematic review of recent data. Viruses. 2019; 11 (5): pii: E463.

  4. Muzammil, Jayanthi D, Faizuddin M, Noor Ahamadi HM. Association of interferon lambda-1 with herpes simplex viruses-1 and -2, Epstein-Barr virus, and human cytomegalovirus in chronic periodontitis. J Investig Clin Dent. 2017; 8 (2).

  5. Mohammad Mukhit Abdul Gaffar Kazi, Renu Bharadwaj. Role of herpesviruses in chronic periodontitis and their association with clinical parameters and in increasing severity of the disease. Eur J Dent. 2017; 11 (3): 299-304.

  6. Zhu C, Li F, Wong MC, Feng XP, Lu HX, Xu W. Association between herpesviruses and chronic periodontitis: a meta-analysis based on case-control studies. PLoS One. 2015; 10 (12): e0144319.

  7. Rodrigues PM, Teixeira AL, Kustner EC, Medeiros R. Are herpes virus associated to aggressive periodontitis? A review of literature. J Oral Maxillofac Pathol. 2015; 19 (3): 348-355.

  8. Botero JE, Parra B, Jaramillo A, Contreras A. Subgingival human cytomegalovirus correlates with increased clinical periodontal parameters and bacterial coinfection in periodontitis. J Periodontol. 2007; 78 (12): 2303-2310.

  9. Bascones-Martínez A, Pousa-Castro. Herpesvirus. Avances en Odontoestomatología. 2011; 27 (1): 11-24.

  10. Slots J. Periodontitis: facts, fallacies and the future. Periodontology 2000. 2017; 75 (1): 7-23.

  11. Dwyer DE, Cunningham AL. Herpes simplex and varicella-zoster virus infections. Med J Aust. 2002; 177 (5): 267-273.

  12. Beauman JG. Genital herpes: a review. Am Fam Physician. 2005; 72 (8): 1527-1534.

  13. Cunningham AL, Breuer J, Dwyer DE, Gronow DW, Helme RD, Litt JC. The prevention and management of herpes zoster. Med J Aust. 2008; 188 (3): 171-176.

  14. Taylor MD. Cytomegalovirus. Am Fam Physician. 2003; 67 (3): 519-524.

  15. Rafailidis PI, Mourtzoukou EG, Varbobitis IC, Falagas ME. Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review. Virol J. 2008; 5: 47.

  16. Crawford DH. Biology and disease associations of Epstein-Barr virus. Philosophical Transactions of the Royal Society B. Biological Sciences. 2001; 356 (1408): 461-473.

  17. De Lejarazu RO, Domínguez-Gil M, Jiménez S. Herpesvirus humano 8: implicaciones patógenas y diagnóstico. Control Calidad SEIMC. 2004; 1-13.

  18. Hong YJ, Lim MS, Hwang SM, Kim TS, Park KU, Song J, Kim EC. Detection of herpes simplex and varicella-zoster virus in clinical specimens by multiplex real-time PCR and melting curve analysis. Biomed Res Int. 2014; 2014: 261947.

  19. Gao Z, Lv J, Wang M. Epstein-Barr virus is associated with periodontal diseases. Medicine (Baltimore). 2017; 96 (6): 1-6.

  20. Carballal G, Oubiña JR. Virus herpes simplex: herpesvirus humano (HHV) 1 y HHV-2. Virología Médica. 2015, pp. 396-400.

  21. Brenner N, Mentzer AJ, Butt J, Michel A, Prager K, Brozy J et al. Validation of multiplex serology detecting human herpesviruses. PLoS One. 2018; 13 (12): e0209379.

  22. Kornfeind EM, Visalli RJ. Human herpesvirus portal proteins: structure, function, and antiviral prospects. Rev Med Virol. 2018; 28 (3): e1972.




2020     |     www.medigraphic.com