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2006, Number S2

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Rev Med Inst Mex Seguro Soc 2006; 44 (S2)

Is oxygen transportation the indicator for the transfusion of erythrocyte concentrates?

Salazar VBY, Tsai AG, Cabrales P, Intaglietta M

Language: Spanish
References: 7
Page: 111-114
PDF size: 70.37 Kb.


ABSTRACT

Experimental studies show that the decision to transfuse blood is not physiologically related with the lack of oxygen transportation or the decrease in tissue pO2. Direct measurements of pO2 and microvascular perfusion in the hamster window-model shows that the clinical decision to transfuse blood is directly related to the decrease in functional capillary density due to hemodilution and hemorrhagic shock.


REFERENCES

  1. Richmond KN, Shonat RD, Lynch RM, Johnson PC. Critical PO2 of skeletal muscle in vivo. Am J Physiol Heart Circ Physiol 1999;277:H1831-H1840.

  2. Intaglietta M, Johnson PC, Winslow RM. Microvascular and tissue oxygen distribution. Cardiovasc Res 1999;32:632-643.

  3. Tsai AG, Johnson PC, Intaglietta M. Oxygen gradients in the microcirculation. Physiol Rev 2003;83:933-963.

  4. Endrich B, Asaishi K, Götz A, Messmer K. Technical report: A new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med 1980;177:125-134.

  5. Cabrales P, Intaglietta M, Tsai AG. Increased plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding. Shock 2005;23:549-555.

  6. Tsai AG. Influence of cell-free hemoglobin on local tissue perfusion and oxygenation after acute anemia after isovolemic hemodilution. Transfusion 2001;41:1290-1298.

  7. Tsai AG, Friesenecker B, McCarthy M, Sakai H, Intaglietta M. Plasma viscosity regulates capillary perfusion during extreme hemodilution in hamster skin fold model. Am J Physiol 1998;275: (Heart Circ Physiol 44) H2170-H2180.




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