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2006, Number S2

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Rev Med Inst Mex Seguro Soc 2006; 44 (S2)

Activation mechanisms of coagulation

Martínez MC

Language: Spanish
References: 30
Page: 51-58
PDF size: 315.03 Kb.


ABSTRACT

In humans and other vertebrates, the blood coagulation system is a first line of defense against vascular trauma. In case of a wound (whether unintentional in accidents or intentional in surgery), blood coagulation rapidly forms a blood clot; the approximate time that it takes for skin bleeding to stop is on average 2–5 minutes if the system is functioning correctly. If there is a defect at some point of the coagulation system, bleeding may be markedly prolonged. The vertebrate blood coagulation system consists of cellular elements (blood platelets, white cells, to some extent red cells and microvascular remnants or microparticles) and proteins (coagulation enzymes and co-factors, and a number of anticoagulant proteins). When blood coagulation is triggered, cells and membrane remnants interact with coagulation factors assembling effective macromolecular complexes that contribute to the formation of fibrin molecules. These fibrin molecules and cells constitute the blood clot formed at the point of damage to the blood vessel.


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