Izaguirre-Ávila R

Language: Spanish
References: 36
Page: 116-123
PDF size: 154.46 Kb.

ABSTRACT

In 1905 Paul Morawitz proposed a blood coagulation theory that have been classic. From then, we have lived several important advances in the field of the hemorrhagic and thrombotic diseases. The discovery of coagulation factors and the enzymatic reactions that generate thrombin and fibrin, gave rise to the development of coagulation tests more precise to diagnose the defects of hemostasis. The discovery of heparin, oral anticoagulants and the antithrombotics properties of the aspirin marked the way for development of more effective antithrombotic drugs. The techniques of separation of the fractions of the plasma allowed to prepare concentrated of coagulation factors and the knowledge of the genes that codify and regulate their synthesis have made possible their production by techniques of molecular Biology. The perspective of the diagnosis and treatment of the hemorrhagic and thrombotic diseases is enormous and has done possible to apply more extensive and effective surgical techniques.

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