González-Trujano ME, Peña-Fajardo EI, Ventura-Martínez R, López-Muñoz FJ

Language: Spanish
References: 35
Page: 80-85
PDF size: 159.17 Kb.

ABSTRACT

Rosmarinus officinalis L. (rosemary, Lamiaceae) is a plant used in Mexican traditional medicine to relieve muscular and arthritic pain. In this study, an ethanol extract of R. officinalis (300 and 3,000 mg/kg, p.o.) was tested in a model to assess analgesic activity known as pain-induced functional impairment model in the rat (PIFIR). The antinociceptive effect of the extract was compared to that produced by tramadol (10 and 31.62 mg/kg, i.p.) over 4 h. The results demonstrated that the extract produced a 60% reduction in the painful response with both doses tested. This effect decreased to 40 and 20% after 1.5 and 2.5 h, respectively. Area under the curve (AUC) data showing the total antinociceptive effect were 164 ± 28%/h and 112 ± 19%/h, respectively. In the case of tramadol, the painful response was reduced 80% with both doses tested. This effect decreased to approximately 60 and 15% at 2 and 3 h, ending with an AUC = 284 ± 17%/h and 144 ± 32%/h, respectively (p ‹ 0.05). The effect of the extract with either of the doses tested was significantly different to tramadol 31.62 mg/kg (p ‹ 0.05), but similar to tramadol 10 mg/kg. The results in this preliminary study confirm the analgesic effect of R. officinalis and support its use in folk medicine.

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