2019, Number 1
<< Back
AbanicoVet 2019; 9 (1)
L-Arginine, Aspartate and Glutamate, and their relationship with the ewes reproduction. Review
Alvarez-Cardona F, Maki-Díaz G, Franco-Robles E, Cadena-Villegas S, Hernández-Marín A
Language: Spanish
References: 52
Page: 1-13
PDF size: 701.08 Kb.
ABSTRACT
In most livestock production systems, it is important to optimize reproductive activity to increase productive
efficiency. This indicator depends on environmental factors such as nutrition, which regulates the onset of
puberty, ovarian follicular development, oocyte quality and, as a result, embryonic development. The
purpose of animal nutrition strategies is to increase reproductive efficiency, to obtain better economic
income in most livestock production systems. Recent research reports that dietary supplementation with
specific amino acids such as arginine, glutamine, leucine, glycine and methionine they have beneficial
effects on survival and embryonic and fetal growth by regulating key signaling and metabolic pathways. In
sheep production systems, supplementation with different routes with neurostimulatory amino acids such
as L-Arginine, aspartate and glutamate, improves reproductive efficiency in females in a technical and
economical way, with the aim of eliminating hormonal manipulation of the animals. Therefore, the objective
of the present review of the literature is to describe the neurostimulatory function of amino acids and to know
the neuroendocrine response in the hypothalamic-pituitary-ovarian axis in sheep to improve productive and
reproductive variables.
REFERENCES
AL-DABBAS FM, Hamra AH, Awawdeh FT. 2008. The effect of arginine supplementation on some blood parameters, ovulation rate and concentrations of strogen and progesterone in female Awassi sheep. Pakistan Journal of Biological Sciences. 11(20): 2389-2394. ISSN: 1028-8880. https://www.ncbi.nlm.nih.gov/pubmed/19137847
BARB CR, Barrett JB, Rampacek GB, Kraeling RR. 1993. N-methyl-DL-aspartate modulation of luteinizing hormone and growth hormone secretion from pig pituitary cell in culture. Life Sciences. 53: 1157-1164. ISSN: 0024-3205. https://doi.org/10.1016/0024- 3205(93)90552-E
BONI R, Santillo R, Macchia G, Spinelli P, Ferrandino G, D´Aniello A. 2006. D-aspartate and reproductive activity and sheep. Theriogenology. 65: 1265-1278. ISSN: 0093-691X. https://doi.org/10.1016/j.theriogenology.2005.07.019
BRANN DW, Mahesh VB. 1994. Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation. Frontiers in Neuroendocrinology. 15: 3-49. ISSN: 0091-3022. https://doi.org/10.1006/frne.1994.1002
BRANN DW, Mahesh VB. 1995. Glutamate: a major neuroendocrine excitatory signal mediating steroid effects on gonadotropin secretion. The Journal of Steroid Biochemistry and Molecular Biology. 53(1-6): 325-329. ISSN: 0960-0760. https://doi.org/10.1016/0960- 0760(95)00070-G
BRANN DW, Mahesh VB. 1997. Excitatory amino acids: evidence for a role in the control of reproduction and anterior pituitary hormone secretion. Endocrine reviews. 18(5): 678- 700. ISSN: 0163-769X. https://doi.org/10.1210/edrv.18.5.0311
BRANN DW. 1995. Glutamate: a major excitatory transmitter in neuroendocrine regulation. Neuroendocrinology. 61: 213-225. ISSN: 0028-3835 https://doi.org/10.1159/000126843
BULBARELA G, Pro-Martínez A, Becerril-Pérez CM, Días-Rivera P, Rosendo-Ponce A, Gallegos-Sánchez J. 2009. Efecto de L-arginina y aceite de pescado en el comportamiento reproductivo de ovejas de pelo sincronizadas con un progestágeno. Agrociencia. 43(4): 371-377. ISSN: 1405-3195. http://www.colpos.mx/agrocien/Bimestral/2009/may-jun/art-4.pdf
CRANE AR, Redden RR, Van Emon ML, Neville TL, Reynolds LP, Caton JS, Schauer CS. 2016. Impacts of supplemental arginine on the reproductive performance of fall lambing ewes. Journal of Animal Science. 94: 3540-3549. ISSN: 1525-3163. https://doi.org/10.2527/jas.2016-0379
D’ANIELLO G, Tolino A, D’aniello A, Errico F, Fisher GH, Di-Fiore MM. 2000a. The role of D-aspartic acid and N-methyl-D-aspartic acid in the regulation of prolactin release. Endocrinology. 141(10): 3862-3870. ISSN: 1945-7170. https://doi.org/10.1210/endo.141.10.7706
D´ANIELLO G, Di-Fiore MM, Fisher GH, Milone A, Seleni AD. 2000b. Occurrence of DAspartic acid and N-metil-D-aspartic acid in in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. The Federation of American Societies for Experimental Biology Journal. 14(5): 699-714. ISSN: 0892-6638. https://doi.org/10.1096/fasebj.14.5.699
DHANDAPANI KM, Brann DW. 2000. The role of glutamate and nitric oxide in the reproductive neuroendocrine system. Biochemistry and Cell Biology. 78(3): 165-79. https://doi.org/10.1139/o00-015
DIXIT VD, Parvizi N. 2001. Nitric oxide and the control of reproduction. Animal Reproduction Science. 65(1-2): 1-16. ISSN: 0378-4320. https://doi.org/10.1016/S0378- 4320(00)00224-4
DOWNING JA, Joss J, Scaramuzzi RJ. 1996. The effects of N-methyl-D-L-aspartic acid and aspartic acid on the plasma concentration of gonadotrophins, GH and prolactin in the ewe. Journal of Endocrinology. 149: 65-72. ISSN: 0022-0795. https://doi.org/10.1677/joe.0.1490065
ESTIENNE MJ, Schillo KK, Green MA, Hileman SM, Boling JA. 1989a. N-methyl-d, laspartate stimulates growth hormone but not luteinizing hormone secretion in the sheep. Life Sciences. 44(21): 1527-1533. ISSN: 0024-3205. https://doi.org/10.1016/0024- 3205(89)90445-1
ESTIENNE MJ, Schillo KK, Hileman SM, Green MA, Hayes SH. 1989b. Effect of N-methyld, l-aspartate on luteinizing hormone secretion in ovariectomized ewes in the absence and presence of estradiol. Biology of Reproduction. 42: 126-130. ISSN: 0006-3363. https://doi.org/10.1095/biolreprod42.1.126
FALETTI AG, Mastronardi CA, Lomniczi A, Seilicovich A, Gimeno M, McCann SM, Rettori V. 1999. β-Endorphin blocks luteinizing hormone-releasing hormone release by inhibiting the nitricoxidergic pathway controlling its release. Proceedings of the National Academy of Sciences. U.S.A. 96: 1722-1726. ISSN: 0027-8424. https://doi.org/10.1073/pnas.96.4.1722
FERNSTROM JD. 2012. Large neutral amino acids: dietary effects on brain neurochemistry and function. Amino Acids (in this issue). ISSN: 1438-2199. https://doi.org/10.1007/s00726-012-1330-y
GROSSMANN AB, Rossmanith WG, Kabigting E, Cadd G, Clifton D, Steiner R. 1994. The distribution of hypothalamic nitric oxide synthase mRNA in relation of gonadotropinreleasing hormone neurons. Journal of Endocrinology. 140(2): R5-R8. ISSN: 0022-0795. https://doi.org/10.1677/joe.0.140R005
HAWKEN PAR, Martin GB. 2012. Sociosexual stimuli and gonadotropin-releasing hormone/luteinizing hormone secretion in sheep and goats. Domestic Animal Endocrinology. 43: 85-94. ISSN: 0739-7240. https://doi.org/10.1016/j.domaniend.2012.03.005
IREMONGER KJ, Constaintin S, Liu X, Herbison AE. 2010. Glutamate regulation of GnRH neuron excitability. Brain Research. 1364: 35-43. ISSN: 0006-8993. https://doi.org/10.1016/j.brainres.2010.08.071
KALB RG. 1995. Current excitement about the glutamate receptor family. The Neuroscientist. 1:60-63. ISSN: 1073-8584. https://doi.org/10.1177/107385849500100201
KIM SW, Mateo RD, Yin YL, Wu G. 2007. Functional amino acids and fatty acids for enhancing production performance of sows and piglets. Asian-Australasian Journal of Animal Sciences. 20(2): 295-306. ISSN: 1011-2363. https://doi.org/10.5713/ajas.2007.295
KWON H, Wu G, Meininger CJ, Bazer FW, Spencer TE. 2004. Developmental changes in nitric oxide synthesis in the ovine placenta. Biology of Reproduction. 70(3): 679-686. ISSN: 0006-3363. https://doi.org/10.1095/biolreprod.103.023184
LI X, Higley A, Song R, Xi ZX. 2013. Effects of metabotropic glutamate receptor ligands on male sexual behavior in rats. Neuropharmacology. 66: 373-381. ISSN: 0028-3908. https://doi.org/10.1016/j.neuropharm.2012.08.006
LUTHER JS, Windorski EJ, Caton JS, Wu G, Kirsch JD, Vonnahme KA, Reynolds LP, Schauer CS. 2009. Effects of arginine supplementation on reproductive performance in Rambouillet ewes. Sheep Research Report. No. 50. North Dakota State Univertity, Fargo. p. 11–13. https://www.ag.ndsu.edu/archive/hettinge/livestock/2009%20Sheep%20Reserch%20Re port/Arginine%20Supplementation%20to%20Ewes%20for%20Increased%20Reproducti ve%20Performance.pdf
MAHESH VB, Braan DW. 2005. Regulatory role of excitatory amino acids in reproduction. Endocrine. 28: 271-280. ISSN: 1559-0100. https://link.springer.com/article/10.1385/ENDO:28:3:271
MARTIN GB, Milton JTB, Davidson RH, Banchero GE, Lindsay DR, Blache D. 2004. Natural methods of increasing reproductive efficiency in sheep and goats. Animal Reproduction Science. 82-83: 231-46. 0378-4320. https://doi.org/10.1016/j.anireprosci.2004.05.014
MATEO RD, Wu G, Bazer FW, Park JC, Shinzato I, Kim SW. 2007. Dietary L-arginine supplementation enhances the reproductive performance of gilts. The Journal of Nutrition. 137(3): 652-656. ISSN: 0022-3166. https://doi.org/10.1093/jn/137.3.652
MAYOR D, Tymianski M. 2018. Neurotransmitters in the mediation of cerebral ischemic injury. Neuropharmacology. 134(B): 178-188. ISSN: 0028-3908. https://doi.org/10.1016/j.neuropharm.2017.11.050
MEZA-HERRERA CA, Torres-Moreno M, Lopez-Medrano JI, Gonzalez-Bulnes A, Veliz FG, Mellado M, Wurzinger M, Soto-Sánchez MJ, Calderón-Leyva MG. 2011. Glutamate supply positively affects serum release of triiodothyronine and insulin across time without increases of glucose during the onset of puberty in the female goat. Animal Reproduction Science. 125:74-80. ISSN: 0378-4320. https://doi.org/10.1016/j.anireprosci.2011.03.011
MEZA-HERRERA CA. 2012. Puberty, kisspeptin and glutamate: A ceaseless golden braid. Chapter 3. In: Advances in medicine and biology. Benhardt, L.V. (ed). Nova Science Publishers, NY, USA. 97-124. ISBN: 978-1-62081-339-3. https://www.researchgate.net/publication/235933762_Puberty_kisspeptin_and_glutamat e_A_ceaseless_golden_braid
MORI M, Gotoh T. 2004. Arginine metabolic enzymes, nitric oxide and infection. The Journal of Nutrition. 134(10): 2820s-2825s. ISSN: 0022-3166. https://doi.org/10.1093/jn/134.10.2820S
RECABARREN SE, Jofré A, Lobos A, Orellana P, Parilo J. 1996. Effect of arginine and ornithine infusions on luteinizing hormone secretion in prepubertal ewes. Journal Animal Science. 74: 162-166. ISSN: 0021-8812. https://doi.org/10.2527/1996.741162x
REYNOLDS LP, Redmer DA. 2001. Angiogenesis in the placenta. Biology of Reproduction. 64(4): 1033-1040. ISSN: 0006-3363. https://doi.org/10.1095/biolreprod64.4.1033
SAEVRE, C, Meyer AM, Van Emon ML, Redmer DA, Caton JS, Kirsch JD, Luther JS, Schauer CS. 2011. Impacts of arginine on ovarian function and reproductive performance at the time of maternal recognition of pregnancy in ewes. Sheep Research Report. North Dakota State University, Fargo. 52: 13-16. https://pdfs.semanticscholar.org/c540/63c9f5742fd22198d92d5cf367aed3343f01.pdf
SCARAMUZZI RJ, Oujagir L, Menassol JB, Freret F, Piezel A, Brown HM, Cognié J, Fabre-Nys C. 2013. The pattern of LH secretion and the ovarian response to the ‘ram effect’ in the anoestrous ewe is influenced by body condition but not by short-term nutritional supplementation. Reproduction Fertility and Development. 26 (8): 1154-1165. ISSN: 1448-5990. https://doi.org/10.1071/RD13139
SOMCHIT-ASSAVACHEEP A. 2011. Influence of nutritional management on folliculogenesis in ewes. Thai Journal of Veterinary Medicine. (Suppl.). 41: 25-29. ISSN: 0125-6491. https://pdfs.semanticscholar.org/2aa1/26edb54f9699e68162edcff1b537947bcc3a.pdf
TAMANINI C, Basini G, Grasselli F, Tirelli M. 2003. Nitric oxide and the ovary. Journal Animal Science. 81(2): E1-E7. ISSN: 0021-8812. https://doi.org/10.2527/2003.8114_suppl_2E1x
TERASAWA E, Fernández DL. 2001. Neurobiological mechanism of the onset of puberty in primates. Endocrine Reviews. Rev. 22: 111-151. ISSN: 0163-769X. https://doi.org/10.1210/edrv.22.1.0418
TSIKAS D. 2007. Analysis of the L-arginine/NO pathway. Journal of Chromatography B. 851: 1-2. ISSN: 1570-0232. https://www.sciencedirect.com/journal/journal-ofchromatography- b/vol/851
URBANSKI HF, Fahy MM, Daschel M, Mashul C. 1994. N-methyl-D-aspartate receptor gene expression in the hamster hypothalamus and in immortalized luteinizing hormonereleasing hormone neurons. Journal of Reproduction and Fertility. 100: 5-9. ISSN: 0022- 4251. http://www.reproduction-online.org/content/100/1/5.long
WEEMS PW, Goodman RL, Lehman MN. 2015. Neural mechanisms controlling seasonal reproduction: principles derived from the sheep model and its comparison with hamsters. Frontiers in Neuroendocrinology. 37: 43-51. ISSN: 0091-3022. https://doi.org/10.1016/j.yfrne.2014.12.002
WIESINGER H. 2001. Arginine metabolism and the synthesis of nitric oxide in the nervous system. Progress in Neurobiology. 64(4): 365-391. ISSN: 0301-0082. https://doi.org/10.1016/S0301-0082(00)00056-3
WILL RG, Hull EM, Dominguez JM. 2014. Influences of dopamine and glutamate in the medial preoptic area on male sexual behavior. Pharmacololgy Biochemistry and Behavior. 121: 115-123. ISSN: 0091-3057. https://doi.org/10.1016/j.pbb.2014.02.005
WU G, Morris SM. 1998. Arginine metabolism: Nitric oxide and beyond. Biochemical Journal. 336: 1-17. ISSN: 0264-6021. https://doi.org/10.1042/bj3360001
WU G. 1998. Intestinal mucosal amino acid catabolism. The Journal of Nutrition. ISSN: 0022-3166. https://doi.org/10.1093/jn/128.8.1249
WU, G. 2010. Functional amino acids in growth, reproduction, and health. American Society for Nutrition. Advances in Nutrition. 1: 31-37. ISSN: 2156-5376. https://doi.org/10.3945/an.110.1008
WU G. 2013. Functional amino acids in nutrition and health. Amino Acids. 45: 407-411. ISSN: 1438-2199. https://doi.org/10.1007/s00726-013-1500-6
Wu G. 2014. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. Journal of Animal Science and Biotechnology. 5: 34. ISSN: 2049- 1891. https://jasbsci.biomedcentral.com/articles/10.1186/2049-1891-5-34
ZAMORANO PL, Mahesh VB, De Sevilla L, Brann DW. 1998. Excitatory amino acid receptors and puberty. Steroids. 63(5-6): 268-270. ISSN: 0039-128X. https://doi.org/10.1016/S0039-128X(98)00033-6
ZARAZAGA LA, Celi I, Guzmán JL, Malpaux B. 2011. The role of nutrition in the regulation of LH secretion by the opioidergic, dopaminergic and serotonergic systems in female Mediterranean goats. Biology of Reproduction. 84: 447-454. ISSN: 1529-7268. https://doi.org/10.1095/biolreprod.110.086520