2019, Number 3
Perioperative benefits of distant ischemic conditioning in coronary revascularization
Language: Spanish
References: 13
Page: 1-15
PDF size: 291.48 Kb.
ABSTRACT
Introduction: A series of brief distant ischemia periods can limit myocardial damage produced by ischemia or reperfusion.Objective: To analyze the differences between the two groups (control and study) taking into account the consumption of inotropics and/or vasopressors during the intraoperative and postoperative periods, as well as the incidence of major cardiac adverse events and mortality in the postoperative period.
Methods: A quasiexperimental, explanatory and comparative study with historical control was conducted on two groups of 247 patients proposed for coronary revascularization. A tourniquet was placed to the right arm, in the study group, alternating three insufflations with three dessufflations with a pressure of 200 mmHg, keeping each for five minutes. This procedure was performed before, during and after the major ischemic event, caused by pinching of the coronary artery.
Results: A significant decrease in the consumption of inotropic and vasoactive drugs was achieved. The decrease in the incidence of low reversible cardiac output, ventricular fibrillation, and new acute myocardial infarction was also proven.
Conclusions: Distant ischemic conditioning is an important tool to be taken into account for perioperative cardiac protection in coronary revascularization.
REFERENCES
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Bromage DI, Pickard JMJ, Rossello X, Ziff OJ, Burke N, Yellon DM, et al. Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis. Cardiovas Research. 2017[acceso: 20/10/2017];113(3):288-97. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408955/