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Revista Médica Sinergia

2020, Number 01

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Revista Médica Sinergia 2020; 5 (01)

Role of nitric oxide in the pathophysiology of cerebral stroke

Fernández AS, Zeledón CN, Rojas JA

Language: Spanish
References: 17
Page: 339
PDF size: 139.87 Kb.


ABSTRACT

Multiple complex pathophysiological processes occur in cerebral stroke that determine primary and secondary brain damage. Nitric oxide plays a fundamental role in the pathophysiology of stroke, represents a primary component in its development and progression. It is closely related to the activation of the inflammatory cascade, the alteration of mitochondrial function, angiogenesis and neurogenesis. These last two processes are fundamental for post-stroke neuroreparation, which is why they have been widely studied. The three production routes of nitric oxide are involved. Nitric oxide can act as a damaging or protective agent depending on where it is produced.


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