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Revista Médica Sinergia

2020, Número 01

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Revista Médica Sinergia 2020; 5 (01)


Rol del óxido nítrico en la fisiopatología del ictus cerebral

Fernández AS, Zeledón CN, Rojas JA

Idioma: Español
Referencias bibliográficas: 17
Paginas: 339
Archivo PDF: 139.87 Kb.


RESUMEN

En el ictus cerebral ocurren múltiples procesos fisiopatológicos complejos que determinan el daño cerebral primario y secundario. El óxido nítrico cumple un papel fundamental en la fisiopatología del ictus, representa es un componente primario en su desarrollo y progresión. Está íntimamente relacionado con la activación de la cascada inflamatoria, la alteración de la función mitocondrial, la angiogénesis y la neurogénesis. Estos últimos dos procesos son fundamentales para la neurorreparación posterior al ictus por lo cual han sido ampliamente estudiados. Las tres vías de producción del óxido nítrico se ven involucradas. El óxido nítrico puede desempeñarse como un agente perjudicial o protector dependiendo de donde se produzca.


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