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Colegio de Medicina Interna de México.

2019, Number 6

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Med Int Mex 2019; 35 (6)

Thrombotic thrombocytopenic purpura

Morales-Montoya A

Language: Spanish
References: 48
Page: 906-911
PDF size: 352.51 Kb.


ABSTRACT

Thrombotic thrombocytopenic purpura is a disease belongs to thrombotic microangiopathies caused by the deficiency or dysfunction of ADAMTS13 protein. It has three possible presentations: chronic, idiopathic or autoimmune, being the last one the most common. Clinical manifestations are variable depending on its time of evolution, it can cause fever, fatigue, arthralgia, abdominal and lumbar pain, as well as myocardial infarction, neurological alterations, renal failure, ischemic stroke and arterial and venous thrombosis. Given the complexity and diversity of the manifestations and complications related to this disease, early and effective diagnosis and treatment are still a little bit difficult; however, now there is a first line treatment which is mainly based on plasma replacement therapy.


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