medigraphic.com
ISSN 0210-5187 (Electronic)

2006, Number 3

<< Back Next >>

Med Cutan Iber Lat Am 2006; 34 (3)

An epidemiological study of psoriasis induced by drugs

Paciel VJ, Vignale R, Calandria L, Paciel LD

Language: Spanish
References: 59
Page: 109-116
PDF size: 376.19 Kb.


ABSTRACT

Psoriasis could be induced or exacerbated by several drugs.
Objective. The hypothesis is the demonstration of a genetic association for the psoriasis induced by drugs.
Material and methods. One hundred and fourteen cases with psoriasis vulgaris (61 men and 53 women). The data for analysis was: (1) family background of psoriasis; (2) others illnes; (3) drugs referred in the bibliography to induce psoriasis and that they are demonstrated as such in the studied population; and (4) drugs that exacerbated the psoriasis. Analysis of the distribution by age of beginning the psoriasis, sex, family background and psoriasis induced by drugs.
Results. Twenty eight out of 114 cases (24,56%) began their psoriasis after the administration of drugs. Six out of 35 cases (17,14%) with family background and 22 out of 79 cases (27,84%) without family background(χ2 = 0,98 p › 0,05). The beginning of psoriasis induced by drugs was: (1) 1/56 ‹ 30 years-old and in 27/58 › 30 years-old (χ2 = 17,56 p ‹ 0,001), (2) 1/39 ‹ 30 years-old and in 21/40 › 30 years-old without family background (χ2 = 12,64 p ‹ 0,001), and (3) 0/17 ‹ 30 years-old and in 6/18 › 30 years-old with family background (χ2 = 3,18 p › 0,05). The beginning age is over in the cases with psoriasis induced by drugs (51,42±13,06 years-old) compared with the one that is not linked to drugs (26,55±12,77 years-old), p ‹ 0,001.
Conclusions. The psoriasis induced by drugs does not depend on a genetic or inheritable condition, suggesting that it is due to a biochemical alteration.


REFERENCES

  1. Saiag P, Coulomb B, Lebreton C, Bell E. Dubertret L.Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro. Science 1985;230:669-72.

  2. Krane JF, Gottlieb AB, Carter DM, Krueger JG. The insulin-like growth factor 1 receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor. J Exp Med 1992;175:1081-90.

  3. Pincelli C, Fantini F, Romualdi P, Sevignani C, Lesa G, Benassi L, Giannetti A. Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes. J Invest Dermatol. 1992;98: 421-7.

  4. Gottlieb AB. Immunologic mechanisms in psoriasis. J Invest Dermatol 1990;95:18-9.

  5. Leung DY, Walsh P, Giorno R, Norris DA. A potential role for superantigens in the pathogenesis of psoriasis. J Invest Dermatol 1993;100:225-8.

  6. Romanus T. Psoriasis from a Prognostic and Hereditary Point of View. Acta Dermatovener (Stockh) 1945;26:1.

  7. Steinberg AG, Becker SW, Fitzpatrick TB, Kierland RR. A genetic and statistical study of psoriasis. Am J Hum Genet 1951;3:267-81.

  8. Abele DC, Dobson RL, Graham JB. Heredity and psoriasis: study of a large family. Arch Dermatol 1963;88:38-47.

  9. Lomholt G. Psoriasis-Praevalenz, spontaner Verlauf und Vererbung. Eine Zensusuntersuchung von den Farinseln. Z Haut Geschlechtskr 1965;38:223-38.

  10. Burch PRJ, Rowell NR. Psoriasis: aetiological aspects. Acta Derm Venerol (Stock) 1965;45:366-80.

  11. Watson W, Cann HW, Farber EM, Nall ML. The genetics of psoriasis. Arch Dermatol 1972;105:197-207.

  12. Farber EM, Nall ML, Watson W. Natural history of psoriasis in 61 twin pairs. Arch Dermatol 1974;109:207-11.

  13. Brandrup F, Holm N, Grunnet N, Henningsen K, Hansen HE. Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution. Acta Derm Venerol (Stock) 1982;62:229-36.

  14. Happle R. Somatic recombination may explain linear psoriasis. J Med Genet 1991;28:337.

  15. Rosbotham JL, Trembath RC, Glover M, Leigh I., Barker JNWN. An association between psoriasis and hereditary multiple exostoses: a clue for the mapping of a psoriasis susceptibility gene? Br J Dermatol 1994;130:671-4.

  16. Swanbeck G, Inerot A, Mar tinsson T, Wahlstrom J. A population genetic study of psoriasis. Br J Dermatol 1994;131:32-9.

  17. Swanbeck G, Inerot A, Mar tinsson T, Enerback C, Enlund F, Samuelsson L, Yhr M, Wahlstrom J. Genetic counselling in psoriasis: empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands. Br J Dermatol 1997;137:939-42.

  18. Grifi ths C. Challenges of assessing psoriasis control. En: Meeting the challenge of managing psoriasis. European Academy of Dermatology and Venereology. Serono Highlight Pak. 2003.

  19. www.aad.org (consultada entre Julio 2001 y agosto 2004). Acceso por Derminfodisc. Derm-on-Disk/Drug Reactions.

  20. Steinke A. Stellungsnahme zu umstritten Fragen beider Psoriasis. Conferencia: Berlin, 1935.

  21. Ingram JT. The signifi cance and management of psoriasis. Br Med J 1954;2:823-41.

  22. Hoede K. Zur Frage der Erblichkeit der Psoriasis. Hautarzt 1957;8:43-51.

  23. L omhol t G. Ps or ias i s : Prevalenc e, Spontaneous Course, and Genetics. A Census Study on the Prevalence of Skin Disease on the Faroe Islands. Copenhagen, Gad, 1963.

  24. Reinberg A. Statistics. En: Psoriasis. E Sidi, ZW Zagula_Mally, M Hincky (eds) Charles C Thomas Publisher. Springfield, Illinois. 1968;279-85.

  25. Henseler T, Christophers E. Psoriasis of early and late onset. Characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 198513:450-6.

  26. Christophers E, Henseler T. Psoriasis types I and II as subtypes of nonpustular psoriasis. Sem Dermatol 1992;11:261-6.

  27. Bolivar I. Curso Práctico de Biometría y Genética. Labor SA. Barcelona. 1952.

  28. Vogel F, Krüger J. Multifactorial determination of genetics affections. En: JF Crown, JV Neel (Ed) Proc 3rd Int Congress Human Genetics. John Hopkins Press, Baltimore. 1967;437.

  29. Farber EM, Nall ML. Genetics of psoriasis: twin study.In: Farber, E. M.; Cox, A. J.: Psoriasis (International Symposium). Stanford Univ. Press. Stanford, 1971;7-13.

  30. Pietrzyk JJ, Turowski G, Kapinska-Mrowka M, Rozanski B. Family studies in psoriasis. I. Complex segregation analysis. Arch Dermatol Res 1982;273:287-94.

  31. Aschner B, Curth HO, Gross P. Genetics aspects of psoriasis. Acta Genet (Basel) 1957;7:197-204.

  32. Grayson LD, Shair HM. Psoriatic family tree. Arch Dermatol 1959;79:661-4.

  33. Ward JH, Stephens FE. Inheritance of psoriasis in a Utah kindred. Arch Dermatol 1961;84:589-92.

  34. Helgren L. Psoriasis. Stockholm, Suecia. Almquist & Wiksell, 1967.

  35. Kimberling WJ, Dobson RL. The inheritance of psoriasis. J Invest Dermatol 1973;60: 538-40.

  36. Falconer DS. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 1965;29:51-71.

  37. Falconer DS. The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus. Ann Hum Genet 1967;31:1-20.

  38. Sagoo GS, Tazi-Ahnini R, Barker JWN, Elder JT, Nair RP, Samuelsson L, Traupe H, Trembath RC, Robinson DA, lies MM. Metaanalysis of genome-wide studies of psoriaisi susceptibility linkage to chromosome 6p21 ans 4q28-q31 in Caucasian and Chinese population. J Invest Dermatol 2004;122: 1401-5.

  39. Hugow T, Artuc M, Henz BM, Mangoldt D, Peters J, Steckelings UM. Arch Dermatol Res 1998;290:49-54.

  40. Steckelings UM, Weihstutz S, Henz BM, Artuc M. Expression of angiotensin AT1- and AT2-receptors in human skin. Arch Dermatol Res 2000;292:139-45.

  41. Steckelings UM, Artuc M, Wollschläger T, Wiehstutz S, Henz BM. Angiotensinconverting enzyme inhibitors as inducers of adverse cutaneous reactions. Acta Derm Venereol 2001;81:321-5.

  42. Michaëlson G, Áhs S, Hammarström I, Pihl Lundin I, Hagforsen E. Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67+ cells in the dermis. Acta Derm Venereol 2003;83: 425-9.

  43. Karvonen SL, Korkiamäki T, Ylä-Uotinen H, Nissinen M, Teerkangas H, Pummi K, et al. Psoriasis and altered calcium metabolism: downregulated capacitative calcium infl ux and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes. J Invest Dermatol 2000;114:693-700.

  44. Cohen AD, Kagen M, Friger M, Halevy S. Calcium chanel blockers intake and psoriasis. A case-control study. Acta Derm Venereol 2001;81:347-9.

  45. McKenzie RC, Oda Y, Szepietowski JC, Behne MJ, Mauro T. Defective ciyclic guanosine monophosphate-gated calcium channels and the patogénesis of psoriasis. Acta Derm Venereol 2003;83:414-8.

  46. Stoebner PE, Carayon P, Penarier G, Fréchin N, Barnéon G, Casellas P, et al. The expresión of peripheral benzodiazepine receptors in human skin: the relationship with epidermal cell differentiation. Br J Dermatol 1999;140:1010-6.

  47. Huang J, Li G, Xiang J, Yin D, Chi R. Immunohistochemical study of serotonin in lesion of psoriasis. Int J Dermatol 2004;43: 408-11.

  48. Kargballe K, Voorhess JJ. Eicosanoids in patogenesis and treatment. En: Psoriasis. HH Roenigk, HI Maibach. (Ed) 2ª edición. Marcel Dekker inc. New York, 1991;371-88.

  49. Peserico A, Semplicini A, Degan P, Padovani S, De Toni R, Cipriani R, et al. Ipertensione arteriosa e sistema renina-angiotensinaaldosterone nella psoriassi. Gior It Derm Vener 1996;121:83-6.

  50. Paciel J, Vignale RA, Pereira A, Severi J, Rodríguez M, Galbarini E. Asociación del locus HLA B a psoriasis. Análisis de una muestra de la población uruguaya. Med Cutan Iber Lat Am 1983;11:155-8.

  51. Russell TJ, Schultes LM, Kuban DJ. Histocompatibility (HL-A) antigens associated with psoriasis. New Eng J Med 1972;287:738-40.

  52. White SH, Newcomer VD, Mickey MR, Terasaki PI.. Disturbance of HL-A antigen frequency in psoriasis. New Eng J Med 1972;287:740-3.

  53. Paciel J, Vignale RA, Pereira A. Modulación de la membrana linfocitaria con anti HLA ABC en psoriasis. Med Cutan Iber Lat Am 1984;12:403-8.

  54. Paciel J, Vignale RA, Bruno J, Vazquez G, De Anda G. Aumento de linfocitos T HLA DR+ en psoriasis. Med Cutan Iber Lat Am 1984;12:497-500.

  55. Elder JT, Nair RJ, Guo SW, Henseler T, Chistophers E, Voorhes JJ. 1994. The genetics of psoriasis. Arch Dermatol 1994;130:216-24.

  56. Leder RO, Mansbridge JN, Hallmayer J, Hodge SE. Familial psoriasis and HLAB: unambiguous support for linkage in 97 published families. Hum Hered 1998;48: 198-211.

  57. Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Westphal E, et al. Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet 2000;66:1833-44. Errata: Am J Hum Genet 2002;70:1074.

  58. Tomfohrde J, Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D, et al. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 1994;264:1141-5.

  59. Mallon E, Bunce M, Savoie H, Rowe A, Newson R, Gotch F, Bunker CB. HLA-C and guttate psoriasis. Br J Dermatol 2000;143: 1177-82.




2020     |     www.medigraphic.com