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2006, Número 3

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Med Cutan Iber Lat Am 2006; 34 (3)


Estudio epidemiológico de la psoriasis inducida por fármacos

Paciel VJ, Vignale R, Calandria L, Paciel LD

Idioma: Español
Referencias bibliográficas: 59
Paginas: 109-116
Archivo PDF: 376.19 Kb.


RESUMEN

La psoriasis puede ser inducida o exacerbada por numerosas fármacos.
Objetivo. La hipótesis de trabajo es la de demostrar una asociación genética de la psoriasis inducida por fármacos.
Material y métodos. 114 casos con psoriasis vulgar (61 hombres y 53 mujeres). Se registró: (1) antecedentes familiares de psoriasis; (2) otras enfermedades; (3) fármacos referidas en la bibliografía como inductoras de psoriasis y que se demuestran como tales en la población estudiada; y (4) que exacerbaron la psoriasis. Análisis de la distribución por edad de inicio de la psoriasis, antecedente familiar y psoriasis inducida por fármacos.
Resultados. 28/114 casos (24,56 %) iniciaron su psoriasis luego de la administración de fármacos. 6/35 casos (17,14 %) con antecedentes familiares y 22/79 casos (27,84 %) sin antecedentes familiares (χ2 = 0,98 p › 0,05). La aparición de psoriasis inducida por fármacos ocurrió en: (1) 1/56 ‹ 30 años y en 27/58 › 30 años ((χ2 = 17,56 p ‹ 0,001), (2) 1/39 ‹ 30 años y en 21/40 › 30 años sin antecedentes familiares ((χ2 = 12,64 p ‹ 0,001), y (3) 0/17 ‹ 30 años y en 6/18 › 30 años con antecedentes familiares ((χ2 = 3,18 p › 0,05). La edad de inicio es mayor en los casos de psoriasis inducida por fármacos (51,42±13,06 años) comparado a la que no se vincula a fármacos (26,55±12,77 años), p ‹ 0,001.
Conclusiones. La psoriasis inducida por fármacos no depende de una condición genética o heredable, sugiriendo que es debida a una alteración bioquímica.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Saiag P, Coulomb B, Lebreton C, Bell E. Dubertret L.Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro. Science 1985;230:669-72.

  2. Krane JF, Gottlieb AB, Carter DM, Krueger JG. The insulin-like growth factor 1 receptor is overexpressed in psoriatic epidermis, but is differentially regulated from the epidermal growth factor. J Exp Med 1992;175:1081-90.

  3. Pincelli C, Fantini F, Romualdi P, Sevignani C, Lesa G, Benassi L, Giannetti A. Substance P is diminished and vasoactive intestinal peptide is augmented in psoriatic lesions and these peptides exert disparate effects on the proliferation of cultured human keratinocytes. J Invest Dermatol. 1992;98: 421-7.

  4. Gottlieb AB. Immunologic mechanisms in psoriasis. J Invest Dermatol 1990;95:18-9.

  5. Leung DY, Walsh P, Giorno R, Norris DA. A potential role for superantigens in the pathogenesis of psoriasis. J Invest Dermatol 1993;100:225-8.

  6. Romanus T. Psoriasis from a Prognostic and Hereditary Point of View. Acta Dermatovener (Stockh) 1945;26:1.

  7. Steinberg AG, Becker SW, Fitzpatrick TB, Kierland RR. A genetic and statistical study of psoriasis. Am J Hum Genet 1951;3:267-81.

  8. Abele DC, Dobson RL, Graham JB. Heredity and psoriasis: study of a large family. Arch Dermatol 1963;88:38-47.

  9. Lomholt G. Psoriasis-Praevalenz, spontaner Verlauf und Vererbung. Eine Zensusuntersuchung von den Farinseln. Z Haut Geschlechtskr 1965;38:223-38.

  10. Burch PRJ, Rowell NR. Psoriasis: aetiological aspects. Acta Derm Venerol (Stock) 1965;45:366-80.

  11. Watson W, Cann HW, Farber EM, Nall ML. The genetics of psoriasis. Arch Dermatol 1972;105:197-207.

  12. Farber EM, Nall ML, Watson W. Natural history of psoriasis in 61 twin pairs. Arch Dermatol 1974;109:207-11.

  13. Brandrup F, Holm N, Grunnet N, Henningsen K, Hansen HE. Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution. Acta Derm Venerol (Stock) 1982;62:229-36.

  14. Happle R. Somatic recombination may explain linear psoriasis. J Med Genet 1991;28:337.

  15. Rosbotham JL, Trembath RC, Glover M, Leigh I., Barker JNWN. An association between psoriasis and hereditary multiple exostoses: a clue for the mapping of a psoriasis susceptibility gene? Br J Dermatol 1994;130:671-4.

  16. Swanbeck G, Inerot A, Mar tinsson T, Wahlstrom J. A population genetic study of psoriasis. Br J Dermatol 1994;131:32-9.

  17. Swanbeck G, Inerot A, Mar tinsson T, Enerback C, Enlund F, Samuelsson L, Yhr M, Wahlstrom J. Genetic counselling in psoriasis: empirical data on psoriasis among first-degree relatives of 3095 psoriatic probands. Br J Dermatol 1997;137:939-42.

  18. Grifi ths C. Challenges of assessing psoriasis control. En: Meeting the challenge of managing psoriasis. European Academy of Dermatology and Venereology. Serono Highlight Pak. 2003.

  19. www.aad.org (consultada entre Julio 2001 y agosto 2004). Acceso por Derminfodisc. Derm-on-Disk/Drug Reactions.

  20. Steinke A. Stellungsnahme zu umstritten Fragen beider Psoriasis. Conferencia: Berlin, 1935.

  21. Ingram JT. The signifi cance and management of psoriasis. Br Med J 1954;2:823-41.

  22. Hoede K. Zur Frage der Erblichkeit der Psoriasis. Hautarzt 1957;8:43-51.

  23. L omhol t G. Ps or ias i s : Prevalenc e, Spontaneous Course, and Genetics. A Census Study on the Prevalence of Skin Disease on the Faroe Islands. Copenhagen, Gad, 1963.

  24. Reinberg A. Statistics. En: Psoriasis. E Sidi, ZW Zagula_Mally, M Hincky (eds) Charles C Thomas Publisher. Springfield, Illinois. 1968;279-85.

  25. Henseler T, Christophers E. Psoriasis of early and late onset. Characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 198513:450-6.

  26. Christophers E, Henseler T. Psoriasis types I and II as subtypes of nonpustular psoriasis. Sem Dermatol 1992;11:261-6.

  27. Bolivar I. Curso Práctico de Biometría y Genética. Labor SA. Barcelona. 1952.

  28. Vogel F, Krüger J. Multifactorial determination of genetics affections. En: JF Crown, JV Neel (Ed) Proc 3rd Int Congress Human Genetics. John Hopkins Press, Baltimore. 1967;437.

  29. Farber EM, Nall ML. Genetics of psoriasis: twin study.In: Farber, E. M.; Cox, A. J.: Psoriasis (International Symposium). Stanford Univ. Press. Stanford, 1971;7-13.

  30. Pietrzyk JJ, Turowski G, Kapinska-Mrowka M, Rozanski B. Family studies in psoriasis. I. Complex segregation analysis. Arch Dermatol Res 1982;273:287-94.

  31. Aschner B, Curth HO, Gross P. Genetics aspects of psoriasis. Acta Genet (Basel) 1957;7:197-204.

  32. Grayson LD, Shair HM. Psoriatic family tree. Arch Dermatol 1959;79:661-4.

  33. Ward JH, Stephens FE. Inheritance of psoriasis in a Utah kindred. Arch Dermatol 1961;84:589-92.

  34. Helgren L. Psoriasis. Stockholm, Suecia. Almquist & Wiksell, 1967.

  35. Kimberling WJ, Dobson RL. The inheritance of psoriasis. J Invest Dermatol 1973;60: 538-40.

  36. Falconer DS. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann Hum Genet 1965;29:51-71.

  37. Falconer DS. The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus. Ann Hum Genet 1967;31:1-20.

  38. Sagoo GS, Tazi-Ahnini R, Barker JWN, Elder JT, Nair RP, Samuelsson L, Traupe H, Trembath RC, Robinson DA, lies MM. Metaanalysis of genome-wide studies of psoriaisi susceptibility linkage to chromosome 6p21 ans 4q28-q31 in Caucasian and Chinese population. J Invest Dermatol 2004;122: 1401-5.

  39. Hugow T, Artuc M, Henz BM, Mangoldt D, Peters J, Steckelings UM. Arch Dermatol Res 1998;290:49-54.

  40. Steckelings UM, Weihstutz S, Henz BM, Artuc M. Expression of angiotensin AT1- and AT2-receptors in human skin. Arch Dermatol Res 2000;292:139-45.

  41. Steckelings UM, Artuc M, Wollschläger T, Wiehstutz S, Henz BM. Angiotensinconverting enzyme inhibitors as inducers of adverse cutaneous reactions. Acta Derm Venereol 2001;81:321-5.

  42. Michaëlson G, Áhs S, Hammarström I, Pihl Lundin I, Hagforsen E. Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67+ cells in the dermis. Acta Derm Venereol 2003;83: 425-9.

  43. Karvonen SL, Korkiamäki T, Ylä-Uotinen H, Nissinen M, Teerkangas H, Pummi K, et al. Psoriasis and altered calcium metabolism: downregulated capacitative calcium infl ux and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes. J Invest Dermatol 2000;114:693-700.

  44. Cohen AD, Kagen M, Friger M, Halevy S. Calcium chanel blockers intake and psoriasis. A case-control study. Acta Derm Venereol 2001;81:347-9.

  45. McKenzie RC, Oda Y, Szepietowski JC, Behne MJ, Mauro T. Defective ciyclic guanosine monophosphate-gated calcium channels and the patogénesis of psoriasis. Acta Derm Venereol 2003;83:414-8.

  46. Stoebner PE, Carayon P, Penarier G, Fréchin N, Barnéon G, Casellas P, et al. The expresión of peripheral benzodiazepine receptors in human skin: the relationship with epidermal cell differentiation. Br J Dermatol 1999;140:1010-6.

  47. Huang J, Li G, Xiang J, Yin D, Chi R. Immunohistochemical study of serotonin in lesion of psoriasis. Int J Dermatol 2004;43: 408-11.

  48. Kargballe K, Voorhess JJ. Eicosanoids in patogenesis and treatment. En: Psoriasis. HH Roenigk, HI Maibach. (Ed) 2ª edición. Marcel Dekker inc. New York, 1991;371-88.

  49. Peserico A, Semplicini A, Degan P, Padovani S, De Toni R, Cipriani R, et al. Ipertensione arteriosa e sistema renina-angiotensinaaldosterone nella psoriassi. Gior It Derm Vener 1996;121:83-6.

  50. Paciel J, Vignale RA, Pereira A, Severi J, Rodríguez M, Galbarini E. Asociación del locus HLA B a psoriasis. Análisis de una muestra de la población uruguaya. Med Cutan Iber Lat Am 1983;11:155-8.

  51. Russell TJ, Schultes LM, Kuban DJ. Histocompatibility (HL-A) antigens associated with psoriasis. New Eng J Med 1972;287:738-40.

  52. White SH, Newcomer VD, Mickey MR, Terasaki PI.. Disturbance of HL-A antigen frequency in psoriasis. New Eng J Med 1972;287:740-3.

  53. Paciel J, Vignale RA, Pereira A. Modulación de la membrana linfocitaria con anti HLA ABC en psoriasis. Med Cutan Iber Lat Am 1984;12:403-8.

  54. Paciel J, Vignale RA, Bruno J, Vazquez G, De Anda G. Aumento de linfocitos T HLA DR+ en psoriasis. Med Cutan Iber Lat Am 1984;12:497-500.

  55. Elder JT, Nair RJ, Guo SW, Henseler T, Chistophers E, Voorhes JJ. 1994. The genetics of psoriasis. Arch Dermatol 1994;130:216-24.

  56. Leder RO, Mansbridge JN, Hallmayer J, Hodge SE. Familial psoriasis and HLAB: unambiguous support for linkage in 97 published families. Hum Hered 1998;48: 198-211.

  57. Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Westphal E, et al. Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet 2000;66:1833-44. Errata: Am J Hum Genet 2002;70:1074.

  58. Tomfohrde J, Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D, et al. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 1994;264:1141-5.

  59. Mallon E, Bunce M, Savoie H, Rowe A, Newson R, Gotch F, Bunker CB. HLA-C and guttate psoriasis. Br J Dermatol 2000;143: 1177-82.




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