2019, Number 3
<< Back Next >>
Acta Med 2019; 17 (3)
Perinatal factors associated with the development of intraventricular hemorrhage in newborn infants
Rojas MC, Vidaña PD, Serna GMÁ, Luna MM, Iglesias LJ, Bernárdez ZI
Language: Spanish
References: 20
Page: 237-242
PDF size: 147.70 Kb.
ABSTRACT
Objective: Describe the perinatal risk factors associated with intraventricular hemorrhage in the newborns hospitalized on neonatal intensive cares.
Methods: We performed a cross-sectional study to analyze the clinical files and cranial sonography of 482 newborns that were admitted to the intensive care unit, that we analyze to find an association between maternal and newborn factors with the development of intraventricular hemorrhage. Data collection was done from January 2016 to December 2017.
Results: An 11% incidence of intraventricular hemorrhage was found. The risk factors for intraventricular hemorrhage was: prematurity with OR of 3.74 (0.92-15.02) p value marginal significant p = 0.06; advanced maternal age with OR of 2.64 (1.21-5.78) p value 0.015. Mechanic ventilation increases the risk of intraventricular hemorrhage by nine times. 9.71 (4.05-23.26 p value less than 0.001). Prenatal administration of steroids presented a decrease of risk of 27% (0.12-0.63) p value less than 0.005.
Conclusions: Perinatal factors such as using mechanical ventilation for more than three days and prematurity constituted risk factors for the development of intraventricular hemorrhage. Some maternal characteristics such as low scholarship and age older than 36 years were risk factors. The use of prenatal steroids had a protective effect in the development of intraventricular hemorrhage.
REFERENCES
Volpe JJ. Intracranial hemorrhage: germinal matrix-intraventricular hemorrhage of the premature infant. In: Neurology of the newborn. 5th ed. Saunders/Elsevier; 2008. p. 1094.
Whitelaw A. Core concepts: intraventricular hemorrhage. NeoReviews. 2011; 12 (2): e94-e101.
Cervantes-Ruiz MA, Rivera-Rueda MA, Yescas-Buendía G, Villegas-Silva R, Hernández-Peláez G. Hemorragia intraventricular en recién nacidos pretérmino en una Unidad de Tercer Nivel en la Ciudad de México. Perinatol Reprod Hum. 2012; 26 (1): 17-24.
Bassan H. Intracranial hemorrhage in the preterm infant: understanding it, preventing it. Clin Perinatol. 2009; 36 (4): 737-62, v.
Sherlock RL, Anderson PJ, Doyle LW; Victorian Infant Collaborative Study Group. Neurodevelopmental sequelae of intraventricular haemorrhage at 8 years of age in a regional cohort of ELBW/very preterm infants. Early Hum Dev. 2005; 81 (11): 909-916.
Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Lui K; New South Wales and Australian Capital Territory Neonatal Intensive Care Units’ Data Collection. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics. 2014; 133 (1): 55-62.
Kenet G, Kuperman AA, Strauss T, Brenner B. Neonatal IVH--mechanisms and management. Thromb Res. 2011; 127 Suppl 3: S120-S122.
Linder N, Haskin O, Levit O, Klinger G, Prince T, Naor N et al. Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case-control study. Pediatrics. 2003; 111 (5 Pt 1): e590-e595.
Ballabh P. Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatr Res. 2010; 67 (1): 1-8.
McCrea HJ, Ment LR. The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate. Clin Perinatol. 2008; 35 (4): 777-792, vii.
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978; 92 (4): 529-534.
Bentlin MR, de Souza-Rugolo LMS. Late-onset sepsis: epidemiology, evaluation, and outcome. NeoReviews. 2010. doi: 10.1542/neo.11-8-e426.
Battaglia FC, Lubchenco LO. A practical classification of newborn infants by weight and gestational age. J Pediatr. 1967; 71 (2): 159-163.
Aly H, Hammad TA, Essers J, Wung JT. Is mechanical ventilation associated with intraventricular hemorrhage in preterm infants? Brain Dev. 2012; 34 (3): 201-205.
López-Candiani C, Soto-Portas LC, Gutiérrez-Castrellón P, Rodríguez-Weber MA, Udaeta-Mora E. Complicaciones de la ventilación mecánica en neonatos. Acta Pediatr Mex. 2007; 28 (2): 63-68.
Boardman JP. Preterm Birth: causes, consequences and prevention. J Obstet Gynaecol. 2008; 28 (5): 559.
Heras-Pérez B, Gobernado-Tejedor J, Mora-Cepeda PM, Almaraz-Gómez A. La edad materna como factor de riesgo obstétrico. Resultados perinatales en gestantes de edad avanzada. Prog Obstet Ginecol. 2011; 54 (11): 575-580.
Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel JP et al. Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG. 2014; 121 Suppl 1: 49-56.
Heaman MI, Moffatt M, Elliott L, Sword W, Helewa ME, Morris H et al. Barriers, motivators and facilitators related to prenatal care utilization among inner-city women in Winnipeg, Canada: a case-control study. BMC Pregnancy Childbirth. 2014; 14: 227.
Wei JC, Catalano R, Profit J, Gould JB, Lee HC. Impact of antenatal steroids on intraventricular hemorrhage in very-low-birth weight infants. J Perinatol. 2016; 36 (5): 352-356.