2006, Number 1
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Med Cutan Iber Lat Am 2006; 34 (1)
Atopic Dermatitis in adults
Laguna AC, Vilata CJJ
Language: Spanish
References: 24
Page: 5-10
PDF size: 237.42 Kb.
ABSTRACT
Atopic dermatitis is a highly pruritic chronic inflammatory skin disorder. The disease results from an interaction between susceptibility genes, the host’s environment, skin barrier defects and immunologycal factors. It’s a common condition that is often thought to predominantly affect infants and children.Reports on adult disease are most exclusively related to the early-onset atopic dermatitis extending into adult life. However, atopic dermatitis may begin for the first time at an adult age, this subgroup is called adult-onset atopic dermatitis.Although a majority of patients has typical flexural distribution and lichenified/ exudative eczematous pattern, a considerable number of patients could have a different distribution and different morphology.Pathogenesis, clinical patterns and distribution, diagnostic criteria, differential diagnosis and management, specially systemic therapies used in severe or resistant cases of atopic dermatitis, are reviewed.
REFERENCES
Bannister MJ, Freeman S. Adult-onset atopic dermatitis. Australas J Dermatol 2000;41:225-8.
Leung D, Bieber T. Atopic dermatitis. Lancet 2003;361:151-60.
Murata Y, OgataJ, Higaki Y et al : Abnormal expresión espingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency .J Invest Dermatol 1996;106: 1242-9.
Tamura K, Suzuki M, Arakawa H et al. Linkage and association studies of STAT-6 gene polimorphisms and allergic diseases. Int Arch Allergy Immunol 2003;131:33-8.
Novak N, Kruse S, Kraft S et al. Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the IL-4/IL-13 receptor gene: the dichotoky of extrinsic and intrinsic atopic dermatitis. J Invest Dermatol 2002;119:870-5.
Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980;92:44-7.
Graham-Brown RC. Atopic dermatitis: predictions,expectations and outcomes.J Am Acad Dermatol 2001;45:561-3.
Esen Ozcaya. Adult-onset atopic dermatitis. J Am Acad Dermatol 2005;52:579-82.
Ingordo V, D´Andria G, D´Andria C. Adult-onset atopic dermatitis in a patch test population. Dermatology 2003;206:197-203.
Diepgen TL, Sauerbrei W, Fartasch M. Development and validation of diagnostic scores for atopic dermatitis incorporating criteria of data quality and practical usefulness. J Clin Epidemiol 1996;49:1031-8.
Oranje AP, de Waard-van der Spek FB. Atopic dermatitis: review 2000 to January 2001. Curr Opin Pediatr 2002;14:410-3.
Lodén M, Anderson A-C, Lindberg M. The number of diagnostic features in patients with atopic dermatitis correlates with dryness severity. Acta Derm Venereol 1999;78:387-8.
Ellis C, Luger T. International Consensus Conference on Atopic Dermatitis II ( ICCADII): clinical update and current treatment strategies. Br J Dermatol 2003;148:3-10.
Sowden JM, Berth-Jones J, Ross JS, et el. Double-blind controlled,crossover estudy of cyclosporin in adults with severe refractory atopic dermatitis. Lancet 1991;338:137-40.
Salek MS, Finlay AY, Luscombe DK,et al. Cyclosporin greatly improves de quality of life of adults with severe atopic dermatitis. A randomized, double-blind,placebo-controlled trial. Br J Dermatol 1993;129:422-30.
Berth-Jones J, Graham-Brown RAC, Marks R, et al. Long-term efficacy and safety of cyclosporin in severe adult atopic dermatitis. Br J Dermatol 1997;136:76-81.
Neuber K, Schwartz I, Itschert G, Tom Dieck A. Treatment of atopic eczema with oral mycofenolate mofetil. Br J Dermatol 2000;143:385-91.
Grundmann-Kollmann M, Podda M, Ochsendorf FR et al. Mycofenolate mofetil is effective in the treatment of atopic dermatitis. Arch Dermatol 2001;137:870-3.
Autio P, Komulainen P, Larni H. Heliotherapy in Atopic dermatitis. A prospective Study on Climatotherapy using the SCORAD index. Acta Derm Venereol 2002;82:436-40.
Paul C, Lahfa M, Bachelez H, Chevret S, Dubertret L. A randomized controlled evaluator-blinded trial of intravenous immunoglobulin in adults with severe atopic dermatitis. Br J Dermatol 2002;147:518-22.
Jolles S. A review of high-dose intravenous immunoglobulin treatment for atopic dermatitis. Clin Exp Dermatol 2002;27:3-7.
Nettis E, Pannofino A, Fanelli M, Feriannini A, Tursi A. Efficacy and tolerability of Montelukast as a therapeutic agent for severe atopic dermatitis in adults. Acta Derm Venereol 2002;82:297-320.
Hanifin JM, Chan SC, Cheng JB, et al. Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol 1996;107:51-6.
Kägi MK, Heyer G. Efficacy of basiliximab,a chimeric anti-interleukin-2 receptor monoclonal antibody, in a patient with severe chronic atopic dermatitis. Br J Dermatol;145:350-51.