2019, Number 08
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Ginecol Obstet Mex 2019; 87 (08)
Thyroid storm in pregnancy: A case report
Novoa-Reyes RH, Llancari-Melendes PA, de la Peña-Meniz WJ, Díaz-Seminario AM, Castillo-Gozzer GA, Cano-Loayza JC, Aguilar-Carrión JN
Language: Spanish
References: 23
Page: 555-562
PDF size: 695.29 Kb.
ABSTRACT
Background: Thyroid storm is a rare complication of hyperthyroidism, with 10 times
greater risk of developing during pregnancy. The term "storm" describes the intensity
of the clinical manifestation and the significant concentration of thyroxine (T4) and
tri-iodothyronine (T3).
Clinical case: Woman of 25 years with a gestational age of 29 weeks with poor
prenatal control, referred to our institution due to fetal tachycardia. Clinically, he had
a heart rate of up to 161 per minute, a fetal heart rate of 178, hot skin, bilateral exophthalmos,
Plumer's nails, bilateral 3N diffuse goiter, bilateral jugular vein enlargement,
bilateral lung crepitations with predominance of bases, lower limb edema. He presented
a score of 60 on the Burch and Wartofsky criteria for thyroid storm. Antithyroid drugs,
beta blockers and support measures were established. Patient developed a threat of
preterm delivery and persistent fetal tachycardia, so an emergency caesarean section
was indicated.
Conclusions: Screening for hyperthyroidism in pregnant women with a personal
history and symptoms is the best measure of thyroid storm prevention. The suspicion
of thyroid storm should be treated immediately by a multidisciplinary team. Fetal
well-being should be evaluated continuously and determine the end of pregnancy if
there are fetal indications or the mother does not respond to the treatment established.
REFERENCES
Sullivan SA, et al. Endocrine emergencies. Obstet Gynecol Clin North Am 2013;40(1):121-135. http://doi. org/10.1016/j.ogc.2012.12.001
Burch HB, et al. Life-Threatening Thyrotoxicosis: Thyroid Storm. Endocrinol Metab Clin North Am. 1993;22(2):263- 277. https://doi.org/10.1016/S0889-8529(18)30165-8
Krassas G, et al. Thyroid function and human reproductive health. Endocr Rev. 2010;31(5):702-755. http://doi. org/10.1210/er.2009-0041
De Leo S, et al. Hyperthyroidism. Lancet. 2016;388 (10047):906- 918. http://doi.org/10.1016/s0140-6736 (16)00278-6
Sheffield JS, et al. Thyrotoxicosis and heart failure that complicate pregnancy. Am J Obstet Gynecol. 2004;190(1):211- 7. http://doi.org/10.1016/S0002-9378(03)00944-X
Briceño-Pérez C, et al. Disfunciones tiroideas y embarazo. Ginecol Obstet Mex 2006;74:462-70. https://ginecologiayobstetricia. org.mx/secciones/articulos-originalesnumero83/ disfunciones-tiroideas-y-embarazo/
Marx H, et al. Hyperthyroidism and pregnancy. BMJ. 2008. 22;336:663-7. http://doi.org/10.1136/bmj.39462.709005.AE
American College of Obstetricians and Gynecologists. Practice Bulletin No. 148: Thyroid disease in pregnancy. Obstet Gynecol. 2015;125(4):996-1005. http://doi. org/10.1097/01.AOG.0000462945.27539.93
Daly MJ, et al. Reversible dilated cardiomyopathy associated with post-partum thyrotoxic storm. QJM. 2009;102(3):217-9. http://doi.org/10.1093/qjmed/hcn173
Fumarola A, et al. Therapy of hyperthyroidism in pregnancy and breastfeeding. Obstet Gynecol Surv. 2011;66(6):378- 85. http://doi.org/10.1097/OGX.0b013e31822c6388
Di Gianantonio E, et al. Adverse effects of prenatal methimazole exposure. Teratology. 2001;64(5):262-266. http:// doi.org/10.1002/tera.1072
Franco D, et al. Hipertiroidismo en el embarazo. Rev Peru Ginecol Obstet. 2018;64(4):569-80. http://dx.doi. org/10.31403/rpgo.v64i2125
Akamizu T. Thyroid Storm: A Japanese Perspective. Thyroid. 2018;28(1):32-40. http://doi.org/10.1089/ thy.2017.0243
Andrade Luz I, et al. Thyroid storm: a case of haemodynamic failure promptly reversed by aggressive medical therapy with antithyroid agents and steroid pulse. BMJ Case Rep. 2018;11(1):e226669. http://doi.org/10.1136/ bcr-2018-226669
De Groot L, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(8):2543-65. http://doi.org/10.1210/jc.2011- 2803
Bahn Chair RS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593-646. http://doi. org/10.1089/thy.2010.0417
Satoh T, et al. 2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition). Endocr J. 2016;63(12):1025-64. http://doi.org/10.1507/endocrj. EJ16-0336
Delport EF. A thyroid-related endocrine emergency in pregnancy. J Endocrinol Metab Diabetes South Africa 2009;14(2):99-101. https://doi.org/10.1080/22201009. 2009.10872201
Rashid M, et al. Obstetric management of thyroid disease. Obstet Gynecol Surv. 2007;62(10):680-8. http://doi. org/10.1097/01.ogx.0000281558.59184.b5
Ma Y, et al. Impending thyroid storm in a pregnant woman with undiagnosed hyperthyroidism: A case report and literature review. Medicine (Baltimore). 2018;97(3):e9606. http://doi.org/10.1097/md.000
Waltman PA, et al. Thyroid storm during pregnancy. A medical emergency. Crit Care Nurse. 2004;24(2):74-79.
Fisher DA. Fetal thyroid function: diagnosis and management of fetal thyroid disorders. Clin Obstet Gynecol. 1997;40(1):16-31. http://doi.org/10.1097/00003081- 199703000-00005
Momotani N, et al. Thyroid function in wholly breast‐feeding infants whose mothers take high doses of propylthiouracil. Clin Endocrinol. 2000;53(2):177-181. https://doi. org/10.1046/j.1365-2265.2000.01078.x