medigraphic.com
ISSN 1995-9427 (Print)

2019, Number 2

<< Back Next >>

Invest Medicoquir 2019; 11 (2)

Cutaneous sensibility to environments fungus and nasal mycobiota study in respiratory allergic patients

Herrera BO, Paneque RI, Rodríguez CJS, Jiménez MM, Otero HL, Ruíz TN, Guedes VLY, Martínez AY, Suárez NNE, Linares LL

Language: Spanish
References: 83
Page:
PDF size: 542.88 Kb.


ABSTRACT

Introduction. The presence of fungi in the respiratory tract can cause allergic manifestations in susceptible persons. They try to analyze the distribution of fungal species isolated from the nasal mucosa of allergic respiratory patients sensitized to fungal allergens and their relationship to skin tests. Methods. Nasal mycobiota study of 186 respiratory allergic patients with positive skin tests for environmental fungi. Results. Of the total number of patients with clinical symptoms of asthma, rhinitis or both, prick skin tests were obtained in 135 of them (72,6 %) with a polysensitization in 73 (54 %). Of Aspergillus fumigatus, Penicillium notatum and Alternaria tenuis, the most relevant cross-reactivity (59,6 %). The culture was positive in 144 nasal samples (77 %) for a coincidence of 26 (18 %) in growths of environmental fungi and bacteria. The predominant genus was Aspergillus spp. (47%). Conclusions. The study of the nasal mycobiota is a test that should be interpreted, together with the skin tests, for the diagnosis of allergic diseases by environmental fungi, taking into account their importance for the epidemiological control in the exposure to fungi.


REFERENCES

  1. PashleyCH, Fairs A, Free RC, Wardlaw AJ: DNA analysis of outdoor air reveals a high degree of fungal diversity, temporal variability, and genera not seen by spore morphology. Fungal Biol. 2012;116:214-224.

  2. Ragab A, Clement P, Vincken W, Nolard N, Simones F. Fungal cultures of different parts of the upper and lower airways in chronic rhinosinusitis. Rhinology. 2006; Mar;44(1):19-25.

  3. Levetin, E. & Horner, W. .Fungal aerobiology: exposure and measurement. Chemical Immunology. 2002;81:10-27.

  4. Díaz A., Fabré D., Coutin G., González, T. La sensibilización a hongos ambientales y su relación con enfermedades atópicas en escolares. Revista Cubana de Medicina General Integral, 2010;26(4):20-29.

  5. Venero S.J., Varona P, Fabre D., Suárez R., Bonet M. & Molina, E. Asma bronquial y rinitis en escolares de ciudad de La Habana (2001 a 2002). Revista Cubana de Higiene y Epidemiología,2009; 47(1): 1-5.

  6. Crameri R, Garbani M, Rhyner C, Huitema C. Fungi: the neglected allergenic sources. Allergy 2014; 69:176–185.

  7. Sullivan SD, Turk F. An evaluation of the cost-effectivness of omalizumab for the treatment of severe allergic asthma. Allergy 2008; 63:670–684.

  8. Denning D W, Pashley C, Hartl D, Wardlaw A, Godet C, Giacco S, Delhaes L, Sergejeva S. Fungal allergy in asthma–state of the art and research needs. Position article and guidelines. Clinical and Translational Allergy 2014, 4:14. Disponible en:http://www.ctajournal.com/content/4/1/14

  9. Fittipaldi M, Nocker A, Codony F: Progress in understanding preferential detection of live cells using viability dyes in combination with DNA amplification. J Microbiol Methods 2012; 91:276–289.

  10. Cottier F, Pavelka N: Complexity and dynamics of host-fungal interactions. Immunol Res. 2012, 53:127–135.

  11. Delhaes L, Monchy S, Frealle E, Hubans C, Salleron J, Leroy S, Prevotat A, Wallet F, Wallaert B, Dei-Cas E, Sime-Ngando T, Chabé M, Viscogliosi E: The airway microbiota in cystic fibrosis: a complex fungal and bacterial community implications for therapeutic management. PLoS One 2012, 7: (4):e36313.

  12. Vautier S, MacCallum DM, Brown GD: C-type lectin receptors and cytokines in fungal immunity. Cytokine 2012, 58:89–99.

  13. Romani L, Puccetti P: Immune regulation and tolerance to fungi in the lungs and skin. ChemImmunol Allergy 2008, 94:124–137.

  14. Stewart A.E., Hunsaker D.H. - Fungus-specific IgG and IgE in allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg., 2002;127(4):324-32

  15. Ezeamuzie CI, Al-Ali S, Khan M, Hijazi Z, Dowaisan A, Thomson MS et al. IgE-mediated sensitization to mould allergens among patients with allergic respiratory diseases in a desert environment. Int Arch Allergy Immunol 2000;121:300–307.

  16. Kalish RS, Askenase PW. Molecular mechanisms of CD8 + T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity. J Allergy ClinImmunol 1999;103:192–199.

  17. Chang C., Gershwin M.E., Thompson G.R. 3rd. - Fungal disease of the nose and sinuses: an updated overview. Curr Allergy Asthma Rep., 2013;13(2):152-161.

  18. Chrdle A, Mustakim S, Bright-Thomas RJ, Baxter CG, Felton T, Denning DW: Aspergillus bronchitis without significant immunocompromise. Ann N Y AcadSci 2012, 1272:73–85.

  19. Patterson K, Strek ME. Allergic bronchopulmonary aspergillosis. Proc Am ThoracSoc 2010;7:237–244.

  20. Simon-Nobbe B, Denk U, Pöll V, Rid R, Breitenbach M. The spectrum of fungal allergy. Int Arch Allergy Immunol 2008;145:58–86.

  21. Fishwick D. New occupational and environmental causes of asthma and extrinsic allergic alveolitis. Clin Chest Med 2012;33:605–616.

  22. Selman M, Lacasse Y, Pardo A, Cormier Y. Hypersensitivity pneumonitis caused by fungi. Proc Am ThoracSoc 2010;7:229–236.

  23. Hamilos DL. Chronic rhinosinusitis: epidemiology and medical management. J Allergy ClinImmunol 2011;128:93–707.

  24. Fokkens W y Cols European Position Paper on Rhinosinusitis and Nasal Polyps. Rhinology 2007; 45; suppl. 20: 1-139

  25. Fokkens W, Lund V, Mullol J. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology. 2007;45:97-101.

  26. Huchton, D.M. : Allergic fungal sinusitis: an otorhinolaryngologicperspective. Allergy Asthma Proc. , 2003;24(5): 307-11.

  27. Laury A.M., Wise S.K. - Chapter 7: Allergic fungal rhinosinusitis. AmJRhinol Allergy., 2013; 27 Suppl 1:26-27.

  28. Ponikau JU., Sherris DA., Kern EB.: Chronic rhinosinusitis: An immune response to fungi. XVIII Congress of European Rhinologic Society. Book of Abstracts: 418, 2000.

  29. Cody DT., Neel III HB., Ferreiro JA., Roberts GD.: Allergic fungal sinusitis: The Mayo Clinic experience. Laryngoscope 1994 Sep;104(9):1074-9.

  30. Schubert MS., Goetz DW.: Evaluation and treatment of allergic fungal sinusitis. I. Demographics and diagnosis. J Allergy ClinImmunol 102:387, 1998.

  31. Denning DW, Pleuvry A, Cole DC. Global burden of allergic bronchopulmonaryaspergilosis with asthma and its complication chronic pulmonary aspergillosis in adults. Med Mycol 2013;51:361–370.

  32. Akinbami LJ. Asthma prevalence, health care use, and mortality: United States 2005–2009. Natl Health Stat Report 2011;32:1–16.

  33. Lotvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF Jr, Wardlaw AJ, Wenzel SE, Greenberger PA: Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011, 127:355–360.

  34. Bush A, Zar HJ: WHO universal definition of severe asthma. Curr.Opin Allergy Clin Immunol 2011, 11:115–121.

  35. Denning DW, O’Driscoll BR, Powell G, Chew F, Atherton GT, Vyas A, Miles J, Morris J, Niven RM: Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma

  36. Sensitization Trial (FAST) study. Am J RespirCrit Care Med 2009, 179:11–18.

  37. Hargreave FE, Nair P: The definition and diagnosis of asthma. Clin.Exp Allergy 2009, 39:1652–1658.

  38. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH: Cluster analysis and clinical asthma phenotypes. Am J RespirCrit Care Med 2008, 178:218–224.

  39. Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM: The link between fungi and severe asthma: a summary of the evidence. Eur.Respir J 2006, 27:615–626.

  40. Matsuoka H, Niimi A, Matsumoto H, Ueda T, Takemura M, Yamaguchi M, et al: Specific IgE response to trichophyton and asthma severity. Chest 2009, 135:898–903.

  41. Mungan D, Bavbek S, Peksari V, Celik G, Gugey E, Misirligil Z: Trichophyton sensitivity in allergic and nonallergic asthma. Allergy 2001, 56:558–562.

  42. Escalante MT, Sanchez-Borges M, Capriles-Hulett A, Belfort E, Di Biagio E, Gonzalez-Aveledo L: Trichophyton-specific IgE in patients with dermatophytosis is not associated with aeroallergen sensitivity. J Allergy Clin Immunol 2000, 105:547–551.

  43. Ward GW Jr, Karlsson G, Rose G, Platts-Mills TA: Trichophyton asthma: sensitisation of bronchi and upper airways to dermatophyte antigen. Lancet. 1989 Apr 22;1(8643):859-62.

  44. Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM: The link between fungi and severe asthma: a summary of the evidence. Eur.Respir. J. 2006, 27:615–626.

  45. Chowdhary A, Agarwal K, Kathuria S, Gaur SN, Randhawa HS, Meis JF: Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview. Crit.Rev.Microbiol 2014, 40:30–48.

  46. Fairs A, Agbetile J, Hargadon B, Bourne M, Monteiro WR, Brightling CE, Bradding P, Green RH, Mutalithas K, Desai D, Pavord ID, Wardlaw AJ, Pashley CH: IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma. Am J RespirCritCareMed 2010, 182:1362–1368.

  47. Aimanianda V, Bayry J, Bozza S, Kniemeyer O, Perruccio K, Elluru SR, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latgé JP:. Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature. 2009 Aug 27;460(7259):1117-21..

  48. Green BJ, Sercombe JK, Tovey ER: Fungal fragments and undocumented conidia function as new aeroallergen sources. J Allergy Clin Immunol. 2005 May;115(5):1043-8.

  49. Green BJ, Mitakakis TZ, Tovey ER: Allergen detection from 11 fungal species before and after germination. J Allergy Clin.Immunol 2003, 111:285–289.

  50. Denning DW, Riniotis K, Dobrashian R, Sambatakou H: Chronic cavitary and fibrosing pulmonary and pleural aspergillosis: case series, proposed nomenclature change, and review. Clin.Infect.Dis 2003, 37(Suppl 3):S265–S280.

  51. Knutsen AP, Slavin RG: Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. Clin.Dev.Immunol 2011, 2011:843763.

  52. Burbach GJ, Heinzerling LM, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S et al. GA(2)Len skin test study II: clinical relevance of inhalant allergen sensitization in Europe. Allergy 2009; 64: 1507–1515.

  53. Agarwal R, Aggarwal AN, Gupta D, Jindal SK: Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis. Int J Tuberc.Lung.Dis 2009, 13:936–944.

  54. Mari A, Schneider P, Wally V, Breitenbach M, Simon-Nobbe B. Sensitization to fungi: epidemiology, comparative skin tests, and IgE reactivity of fungal extracts. Clin.Exp.Allergy 2003; 33: 1429–1438.

  55. Corradini, C., Del Ninno, M., Schiavino, D., Patriarca, G. and Paludetti G. Allergic fungal sinusitis. A nasosinusal specific hyperreactivity for an infectious disease? Acta Otorhinolaryngol Ital., 2003;23(3):168-74.

  56. Slater JE, Menzies SL, Bridgewater J, Mosquera A, Zinderman CE, Ou AC et al. The US Food and Drug Administration review of the safety and effectiveness of non standardized allergen extracts. J Allergy.Clin.Immunol 2012; 129:1014–1019.

  57. Kurup VP. Fungal Allergy. In: Arora N editor. Handbook of Fungal Biotechnology. New York: Dekker, 2003:515–525.

  58. American Academy of Allergy. Asthma and Immunology (AAAAI). The use of standardized allergen extracts. J Allergy Clin.Immunol 1997; 99: 583–586.

  59. Glaser AG, Menz G, Kirsch AI, Zeller S, Crameri R, Rhyner C. Auto- and cross-reactivity to thioredoxin allergens in allergic bronchopulmonary aspergillosis. Allergy 2008; 63: 1617–1623.

  60. Limacher A, Glaser AG, Meier C, Schmid-Grendelmeier P, Zeller S, Scapozza L et al. Cross-reactivity and 1.4-Å crystal structure of Malasseziasym podialis thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol 2007;178:389–396.

  61. Rid R, Onder K, Hawranek T, Laimer M, Bauer JW, Holler C et al. Isolation and immunological characterization of a novel Cladosporium herbarum allergen structurally homologous to the alpha/beta hydrolase fold superfamily. MolImmunol 2010;47: 1366–1377.

  62. Chang C., Gershwin M.E., Thompson G.R. 3rd. - Fungal disease of the nose and sinuses: an updated overview. Curr Allergy Asthma Rep., 2013; 13(2):152-161.

  63. Rojas, T.I., Martínez, E., Aira, M.J. & Almaguer, M. Aeromicota de ambientes internos: Comparación de métodos de muestreo. Boletín micológico, 2008;23: 67-73.

  64. Polizzi, V.; Delmulle, B.; Adams, A.; Moretti, A.; Susca, A.; Picco, A.M.; Rosseel, Y.; Kindt, R.; van Bocxlaer, J.; de Kimpe, N.; et al. JEM Spotlight: Fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings. J. Environ. Monit. 2009, 11, 1849–1858.

  65. Fundora HH, Venero SJ. F, Rodríguez A B, Alerm AG, León E T, Cubas I D. Immunoepidemiology of bronchial asthma. Revista Cubana de Higiene y Epidemiol 2011;49(3):459-469.

  66. Varona PP, Fabré DEO, Venero SF, Suárez R M, Molina E E, Romero P, Allergic rhinitis, prevalence and risk factors among Cuban Adolescents Manuel. Revista Cubana de Higiene y Epidemiología. 2014;52 (3):330-345

  67. Álvarez CM. Herrera BO. Castro AR. Sensibilización cutánea a ácaros y enfermedades alérgicas, en pacientes atendidos en el Hospital Universitario “Calixto García”. Revista Investigaciones Médico quirúrgicas. 2009;1(3): 20

  68. Resamo A, Sanz ML, Oehling A. Sensitizations to Alternaria and Cladosporium in asthmatic patients and it’s in vitro diagnostic confirmation. J Investig Allergol ClinI mmunol 1998; 8: 353-358.

  69. Castillo FM, Ramos AJ, Soler R,Fungal Sensitization in Nasal Polyposis. J Investig.Allergol.ClinImmunol 2009; 19(1): 6-12

  70. Dales RE, Cakmak S, Burnett RT, Judek S, Coates F, Brook JR. Influence of ambient fungal spores on emergency visits for asthma to a regional children’s hospital. Am J Respir Crit Care Me 2000; 162: 2087-2090.

  71. Hardin BD, Kelman BJ, Saxon A. Adverse human health effects associated with molds in the indoor environment. J Occup Environ Med 2003; 45: 470-478.

  72. O’Driscoll BR, Hopkinson LC, Denning DW. Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm.Med 2005 Feb 18;5:4.

  73. Mitakakis TZ, Tovey ER, Xuan W, Marks GB. Personal exposure to allergenic pollen and mould spores in inland New South Wales, Australia. Clin Exp Allergy. 2000 Dec;30(12):1733-9.

  74. Almaguer, M. y Rojas-Flores, T. I.: Aeromicota viable de la atmósfera de La Habana, Cuba. Nova Acta Científica Compostelana (Bioloxía), 2013;20: 35-45

  75. Díaz RA, Fabré OD, Coutin MG, Revista Cubana de Medicina General Integral.2010; 26(4)647-655

  76. Vargas Ortega E, Castrejón Vázquez MI, Galicia Tapia J. Alergenos más frecuentes en pacientes alérgicos atendidos en un hospital de tercer nivel. Revista Alergia México. Julio-agosto 2004;51(4):145-50.

  77. Mitsuhiko Nambu, MD, PhD,1 Hisashi Kouno, MT,2 Maki Aihara-Tanaka, PhD,3 Hideharu Shirai, 4 and Kosuke Takatori, DVM, PhD3 Detection of Fungi in Indoor Environments and Fungus-Specific IgE Sensitization in Allergic Children. 1Department of Pediatrics and 2Department of Clinical Pathology, Tenri Hospital, Tenri, Nara, Japan; the 3Division of Microbiology, National Institute of Health Sciences, Tokyo, Japan; and 4Institute ofTokyo

  78. Environmental Allergy, Tokyo, Japan. Copyright © 2009 by World Allergy Organization

  79. Cruz A, Saenz de Santamaria M, Martinez J, Martinez A, Guisantes J, Palacios R. Fungal allergens from important allergenic fungi imperfecti. Allergol.Immunopathol 1997; 25: 153-158.].

  80. Crameri R. The crux with a reliable in vitro and in vivo diagnosis of allergy. Allergy 2013; 68:693–694.

  81. Rojas, T.I. &Aira, M.J.Fungal biodiversity in indoor environments in Havana, Cuba. Aerobiologia, 2012;28: 367–374.

  82. Muñoz S, Herrera ML, Montero A. Pacientes con componente alérgico y su relación con la presencia de agentes micóticos. Revista Médica del Hospital Nacional de Niños. Rev. méd. Hosp. Nac. Niños (Costa Rica).1995 Jan;30(1-2): Disponible en: http://www.scielo.sa.cr/scielo.

  83. García Caballero R, Nader O, Morfin Maciel B. Correlación entre pruebas cutáneas positivas a hongos, IgE total, e IgE específica por ELISA y cultivos de hongos en el medio ambiente del paciente pediátrico alérgico. Disponible en: http://www.imbiomed.com.mx/1/1/articulos.php




2020     |     www.medigraphic.com