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Revista Médica Sinergia

2019, Number 06

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Revista Médica Sinergia 2019; 4 (06)

DRESS syndrome: diagnostic and therapeutic approach

Gómez CMT, Corrales MTM, Ugalde JO

Language: Spanish
References: 18
Page: 60-72
PDF size: 516.92 Kb.


ABSTRACT

Medications are elements that improve our quality of life in different ways. However, with the use of medications we can have side effects related to the interaction between medication-medication, medicationfood, medication-supplements, drugs-diseases, and finally drugs and the human body. The eosinophilic drug reaction syndrome and systemic symptoms, is a serious infrequent and potentially fatal toxicoderma. The chronology covers a long-time interval between the intake of the medication and the appearance of the first symptoms (2-8 weeks). Its pathophysiology is not fully elucidated. An immune response is involved against the drug or its metabolites in a context of genetic susceptibility (expressed by the association of some human leukocyte antigens [HLA] and / or metabolism abnormalities of the drug) and a reactivation of herpes virus (human herpes virus) 6 [VHH-6], VHH-7, Epstein-Barr virus, cytomegalovirus), with a T lymphocyte immune response directed against these viruses. The diagnosis of this syndrome is confirmed by clinical and paraclinical diagnostic criteria. The treatment is not well standardized, but it is based on the interruption of the presumed medication involved and on corticosteroid therapy.


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