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Revista Médica Sinergia

2019, Number 06

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Revista Médica Sinergia 2019; 4 (06)

Intrahepatic cholestasis in pregnancy

Espinoza AA, Vílchez LM, Webb WK

Language: Spanish
References: 17
Page: 14-23
PDF size: 403.53 Kb.


ABSTRACT

Intrahepatic cholestasis of pregnancy is the most common pregnancyspecific liver disease and typically occurs during the second trimester or third trimester of pregnancy. It has a multifactorial etiology, which will depend on genetic characteristics and hormonal influences, among other variables. It is characterized by pruritus and alterations of laboratory parameters, such as elevation of bile acids and alteration of liver function tests. It is still poorly understood and because the guidelines have not yet been standardized, it has different diagnostic criteria. The treatment pillar consists of ursodeoxycholic acid. It is usually benign for women with rapid resolution after childbirth, but is associated with adverse perinatal complications, including preterm birth and intrauterine fetal death. There is still much to explore and determine regarding this complex pathology, in order to reach a consensus among the different guides and to obtain the best recommendations for the population worldwide.


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