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ISSN 1561-3011 (Electronic)

2018, Number 2

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Rev Cubana Invest Bioméd 2018; 37 (2)

Magnetic field of extremely low frequency: Safety of its application at the level of the central nervous system

Marañón CM, Mancebo RA, Pérez FL, García RJC, Gilart GF, Marañón REJ

Language: Spanish
References: 27
Page: 75-86
PDF size: 286.39 Kb.


ABSTRACT

Introduction: Stroke is a major health problem all over the world. Nowadays are developed scientific researches devoted to the study of extremely low frequency magnetic field effects over this illness. The information about it safety is unclear yet.
Objective: To study the safety of extremely low frequency magnetic field applied at central nervous system level was by means of a toxicological assay (Acute, repeated doses and micronucleus in bone marrow assay).
Methods: Three experimental groups were made with Sprague Dawley Cenp: SPRD young and healthy rats for toxicity experiments and CENP: NMRI mice for mutagen evaluation. Untreated negative controls were used. In the micronucleus assay, an additional positive control group was included. This group received Cyclophosphamide by intraperitoneal administration. Was applied a non-homogenous magnetic field of 6,5 and 15 mT, taken as reference the maximum value over the coil surface. The coil was positioned over the head, ensuring full exposure of brain to magnetic field.
Results: In none of trials were detected any sign of toxicity. It was also found no genotoxic or cytotoxic effects induced on somatic cells.
Conclusions: These results indicated the safety of treatment with extremely low frequency magnetic field at central nervous system level for experimental conditions and doses studied.


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