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2018, Number 1

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Rev Cubana Invest Bioméd 2018; 37 (1)

NCS-1 in neuronal function

Sánchez JC, García AM

Language: Spanish
References: 84
Page: 95-110
PDF size: 264.62 Kb.


ABSTRACT

NCS-1 is a calcium-binding protein, which regulates the functioning of diverse proteins, with which interacts to a molecular level. Its expression is widespread and it is not limited to neurons. Its effects include the regulation of receptors, ion channels and enzymes, which intervene in multiple neuronal functions. NCS-1 regulates the functioning of D2 dopamine receptor and adenosine A2A receptor, both fundamental in diverse communication processes that involve emotional and movement control in a variety of neural circuits. NCS-1 also regulates the activity of IP 3 receptor, an intracellular calcium ion channel (which is crucial in the regulation of calcium homeostasis), interacts with the IP kinases, which trigger intracellular signaling cascades, and modulates the activity of presynaptic calcium channels. All these effects lead to the regulation of neurotransmitters release and thus, synaptic plasticity, which had been proved in diverse experimental models. NCS-1 also appears to be involved in the regulation of other calcium and potassium channels, which can influence the neuron electric homeostasis and survival through the modulation of proapoptotic pathways. These broad NCS-1 effects motivate further research of the specific mechanisms that are involved in the regulation that this protein exerts on its target proteins and in new effects that may help to understand the role of this protein in physiological and pathophysiological processes.


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