2019, Number 2
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Odovtos-Int J Dent Sc 2019; 21 (2)
Sjögren Syndrome and Mucous Membrane Pemphigoid in a Patient with a History of Thymoma: Case Report and Literature Review
Boza OYV, Tinoco ME, Guillén CD, Torres LR
Language: Spanish
References: 39
Page: 33-44
PDF size: 244.71 Kb.
ABSTRACT
Thymomas are the most common mediastinal neoplasms in adults. Patients with thymoma
are frequently diagnosed with paraneoplastic syndromes and are generally associated with several
autoimmune conditions. Sjögren's syndrome (SS) is an autoimmune inflammatory disorder, characterized
by the lymphocyte-mediated destruction of the exocrine glands, which leads to the absence of glandular
secretion, particularly salivary and lacrimal; hyposalivation can vary from a slight reduction in the flow
of saliva with transient discomfort, to a serious deterioration of oral health and psychological distress.
Mucous membrane pemphigoid (MMP) is a chronic, autoimmune disease that shows predominant mucosal
involvement, most commonly affecting the oral cavity, followed by the conjunctiva, the nasal cavity and
the esophagus; intraorally includes scaly gingivitis, vesicles, erosions covered by pseudomembranes
and ulcers. The objective of this work is to present the first case of a patient with a history of thymoma,
which, jointly presented SS and MMP; also highlight the importance of multidisciplinary management for
an accurate and early diagnosis, as this increases the efficiency and efficacy of the treatment strategy.
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