2019, Number 1
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Rev Med Inst Mex Seguro Soc 2019; 57 (1)
The possible origin of Legg-Calvé- Perthes disease
Padilla-Santamaría F, Maya-Franco L, Bolaños-Méndez GZ, Guerrero-Gómez DA
Language: Spanish
References: 24
Page: 36-41
PDF size: 179.88 Kb.
ABSTRACT
Legg-Calvé-Perthes disease (LCPD) is a childhood
orthopedic pathology that affects the development of the
hip. It is a rare disease with a huge variation in annual
incidence. It occurs approximately five times more often
in boys than in girls. The objective of this article was to
formulate a hypothesis about the possible origin of
LCPD, from the paleopathological findings of this
disease reported until 2017, and to highlight the
importance of anthropology, history, paleontology and
paleopathology to the study of the origins of disease. By
using eight web-based search engines, we performed a
review of articles focused on the history, genetics and
paleopathological findings of LCPD; we evaluated in
total 133 articles published between 1910 and 2017. Out
of these, 20 articles belonging to the same publication
period were included in this analysis. LCPD was
described for the first time approximately 100 years ago
and without knowing it was a new disease. In the last
years, human remains have been found in which LCPD
has been identified, providing relevant information about
the origin of this pathology. These data and their
historical context can be a basis to propose the Asian
continent as the site of origin of LCPD; however, new
anthropological, genetic and paleopathological studies
are needed to reinforce or refute this hypothesis.
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