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2018, Number 2

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Rev Mex Med Repro 2018; 8.9 (2)

Administration of metformin in women with polycystic ovary syndrome and its effect on fertilization in vitro

Mateo-Sánez HA, Rentería-Vega GA, Frausto-Jaime JA, Mateo-Madrigal M, Mateo-Madrigal V, Mateo-Madrigal D

Language: Spanish
References: 21
Page: 31-37
PDF size: 253.57 Kb.


ABSTRACT

Objective: To show the beneficial impact of metformin in women with polycystic ovary syndrome and success in IVF in the Fertility Clinic of Baja California.
Material and Method: A randomized controlled clinical trial in women with polycystic ovary syndrome, which were subjected to treatment IVF, from January 2015 to December 2015, in the Fertility Clinic of Baja California, in the Santa Rosa de Lima Hospital. There were included female patients between 30 and 40 years old, who were divided into two groups: one group were administered with Dabex (metformin) 500 mg oral with dinner; increasing gradually the dose of 500 mg weekly to reach 1.5 g and Yasmin oral (3.0 mg drospirenone and 0.03 mg ethinylestradiol) every 24 hours for 3 weeks. The other group took oral Yasmin (drospirenone and 0.03 mg ethinylestradiol 3.00 mg). SPSS (Statistical Analysis Software Package) 21 program was used for statistical analysis.
Results: There were included 17 patients; there were no statistically significant in terms of the characteristics of the patients studied differences. The patients with polycystic ovary syndrome who took metformin (n = 8) obtained an implantation rate of 18.7% and a clinical pregnancy rate of 37.5%. Patients with polycystic ovary taking contraceptive pills (n = 9) had 3.4% and 22%, respectively.
Conclusion: The administration of metformin improved the success of IVF in women with polycystic ovary.


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