Villalpando-Gómez Y, Espinosa-Soto I, Ramírez-Estudillo JA, Robles-Contreras A

Language: Spanish
References: 23
Page: 123-128
PDF size: 166.08 Kb.

ABSTRACT

Background: Smoking and nicotine are known risk factors for cardiovascular diseases, so it is expected that these are associated with vascular changes in the organism, including the choroidal vasculature. Purpose: To evaluate the effects of nicotine on choroidal thickness in healthy patients by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: Case-control study, in which choroidal thickness was measured in healthy subjects after consuming a chewing gum with 4 mg nicotine and compared with a control group given a nicotine-free chewing gum. For descriptive statistics frequencies, means and standard deviation were used. For inferential statistics, one-way analysis of variance was used for intergroup comparison. Results: Sixty four eyes were included. In the comparison of choroidal thickness in the control group at baseline, at 1 hr and 2 hrs, no significant difference was observed (p = 0.29, p = 0.13, respectively). Otherwise, when we performed the comparison of the group with nicotine, we did not observe a statistical significance between basal choroidal thickness, at 1 hr and 2 rhrs (p = 0.57, p = 1.43, respectively). Conclusion: In our study we did not observe that the chewing gum with nicotine generated transient changes in the choroidal thickness, these changes could be related to the chronic consumption of nicotine and with the consequent damage generated by it.

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