medigraphic.com
ISSN 1726-6718 (Electronic)
Revista Cubana de Anestesiología y Reanimación

2018, Number 1

<< Back Next >>

Revista Cubana de Anestesiología y Reanimación 2018; 17 (1)

Neuromuscular-blocking drugs interaction with drugs used in anesthesiology

Cordero EI

Language: Spanish
References: 26
Page: 1-11
PDF size: 100.31 Kb.


ABSTRACT

Introduction: Drug interaction is understood as the ability of a drug for altering the pharmacological effects of another simultaneously administered.
Objective: To carry out an updated review about the drug interaction of neuromuscular-blocking drugs with others frequently used in the anesthesiological field.
Findings: The mechanisms of drug interaction are varied and are complicated in cases of modifications on the pharmacokinetical and pharmacodynamical properties of each medicine. Neuromuscular-blocking drugs (NMBs) are used to relax the striated musculature and to ensure tracheal intubation, ventilation. They produce a sufficient surgical plane in order for the surgeon to perform the surgical procedure properly. Many medications interact with NMBs and often potentiate the muscle relaxant effect. This is of clinical importance in the case of antibiotics, inhalational anesthetics, lithium and cyclosporine.
Conclusions: Modern anesthesiologists must have sufficient theoretical knowledge about different drug interactions that may occur during the perioperative period. Neuromuscular-blocking drugs can interact with others commonly used by patients or by the anesthesiologists, a reason why early diagnosis and appropriate treatment are necessary to avoid complications.


REFERENCES

  1. Paladino MA. Interacciones farmacológicas. ¿Qué hacemos con las drogas que está tomando el paciente antes de la anestesia?. [citado 30 ago 2011]. Disponible en: http://profesional.medicinatv.com/fmc/paladino4/interacciones.asp

  2. Villalonga Morales JA. Interacciones medicamentosas y anestesia. [citado 23 ago 2011]. Disponible en: http://www.feea.net

  3. Sánchez Arredondo CM. Relajantes musculares y sus interacciones. Fármacos. 2002;15(2):25-33.

  4. Franco Yepes HD. Interacciones farmacológicas en anestesia. [citado 29 ago 2011]. Disponible en: http://es. Scribd.com/doc/577719528/Cap5-Interacciones farmacológicas-en-anestesia

  5. Ostergaard D, Engbaek J, Viby-Mogensen J . Adverse reactions and interactions of the neuromuscular blocking drugs. Med Toxicol Adverse Drug Exp . 1989;4(5):351-68.

  6. Ariza de Arteaga M. Unión neuromuscular y relajantes musculares. [citado 25 ago 2011]. Disponible en: http://www.anestesianet.com/unal/rnm.htm

  7. Feldman S, Karalliedde L . Drug interactions with neuromuscular blockers. Drug Saf . 1996;15(4):261-73.

  8. Flores Martínez LU. Interacciones farmacológicas en anestesiología. [citado 30 ago 2011] Disponible en: http://www.slideshare.net/wilderhagen/interaccionesfarmacolgicas- en-anestesiologaInteracciones farmacológicas en anestesiología- Presentation Transcript

  9. Cammu G . Interactions of neuromuscular blocking drugs. Acta Anaesthesiol Belg . 2001;52(4):357-63.

  10. Amin AM, Mohammad MY, Ibrahim MF. Comparative study of neuromuscular blocking and hemodynamic effects of rocuronium and cisatracurium under sevoflurane or total intravenous anesthesia. Middle East J Anesthesiol . 2009;20(1):39-51.

  11. Braga Ade F, Carvalho VH, Braga FS, Rodrigues-Simioni L, Loyola YC, Potério GB . Influence of local anesthetics on the neuromuscular blockade produced by rocuronium: effects of lidocaine and 50% enantiomeric excess bupivacaine on the neuromuscular junction. Rev Bras Anestesiol . 2009;59(6):725-34.

  12. Loyola YC, Braga Ade F, Potério GM, Sousa SR, Fernandes SC, Braga FS. Influence of lidocaine on the neuromuscular block produced by rocuronium: study in rat phrenic-diaphragmatic nerve preparation. Rev Bras Anestesiol 2006;56(2):147- 56.

  13. Sousa SR, Braga Ade F, Potério GM, Braga FS, Loyola YC, Fernandes SC. Influence of nifedipine on the neuromuscular block produced by atracurium and cistracurium: study in rat phrenic-diaphragmatic nerve preparation. Rev Bras Anestesiol . 2006;56(2):157-67.

  14. Fernandes SC, Braga AF, Braga FS, Loyola YC, Souza SR, Barcelos CC. Influence of lithium on the neuromuscular blockade produced by atracurium and cisatracurium: study on rat phrenic nerve-diaphragm preparations. Rev Bras Anestesiol . 2007;57(3):289-300.

  15. Kira S. Resistance to vecuronium induced muscle relaxation in a patient with mental retardation receiving phenytoin for chronic anticonvulsant therapy. Masui . 2011;60(1):80-3.

  16. Fernández-Candil J, Gambús PL, Trocóniz IF, Valero R, Carrero E, Bueno L, Fábregas N. Pharmacokinetic-pharmacodynamic modeling of the influence of chronic phenytoin therapy on the rocuronium bromide response in patients undergoing brain surgery. Eur J Clin Pharmacol . 2008;64(8):795-806.

  17. Soriano SG. Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsivant therapy. Br J Anaesth. 2001;86:223-9.

  18. Fernandes SC, Oshima Franco Y, Mantovani M, Rodrigues Simioni L. Phenobarbital influence on neuromuscular block produced by rocuronium in rats. Acta Cir Brás. 2008 [citado 2 ago 2011];23(4). Disponible en: http://dx.doi.org/10.1590/S0102- 86502008000400008

  19. Tripathi CB, Bhatt JD, Panchakshari UD, Hemavathi KG, Gulati OD. Interaction between H2-receptor blocker and neuromuscular blockers in vitro. Indian J of Pharmacol. 2002;34:189-93.

  20. El Ayass N, Hendrickx P. Decreased mivacurium infusion rate and delayed neuromuscular recovery after metoclopramide: a randomized double blind placebocontrolled study. Eur J Anaesthesiol. 2005;22(3):197-201.

  21. Sterling E, Winstead S, Fahy BG. Guide to neuromuscular blocking agents. Anesthesiology News Special Edition. New York:Mac Mahon Publisher; 2007. p. 25-30.

  22. Bentué-Ferrer D, Tribut O, Polard E, Allain H. Interacciones farmacológicas clínicamente significativas de los inhibidores de la colinesterasa: Una guía para neurólogos. Drugs. 2005;17(13):947-63.

  23. Ostergaard D. The influence of drug-induced low plasma cholinesterase activity on the pharmacokinetics and pharmacodynamics of mivacurium. Anesthesiology. 2000;92:1581-7.

  24. Searl TJ, Silinsky EM. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction. Br J Pharmacol. 2010;161(3):659-67.

  25. Zwiers A, Van den Heuvel M, Smeets J, Rutherford S. Assessment of the potential for displacement interactions with sugammadex: a pharmacokineticpharmacodynamic modelling approach. Clin Drug Investig . 2011;31(2):101-11.

  26. Sunaga H, Zhang Y, Savarese JJ, Emala CW. Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology. 2010;112(4):892-99.




2020     |     www.medigraphic.com