medigraphic.com
Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2019, Number 2

<< Back Next >>

Rev Mex Oftalmol 2019; 93 (2)

Diabetic Retinopathy Clinical Research Network: Diabetic retinopathy and diabetic macular edema. Review article

Palomares-Ordóñez JL, Rojas-Juárez S, Sánchez-Ramos JA, Salas-García JA, Pita-Ortíz I, Hernández AY, Pérez-Montaño CR, Ramírez-Estudillo JA

Language: Spanish
References: 41
Page: 84-97
PDF size: 194.15 Kb.


ABSTRACT

The diabetic retinopathy clinical research network (DRCR.net), founded by the National Eye Institute, was formed in 2002. Currently it includes over 400 ophthalmologists in 115 clinical centers in 37 states of the United States. Since then, it has conducted several studies on various points of interest about diabetic retinopathy and diabetic macular edema. To date, the DRCR.net has published about 80 articles, including clinical trials (named with alphabetic letters), observational studies and various sub analyses derived from the primary studies. The results obtained provide retina specialists with substantial evidence regarding the treatment protocols classically proposed. Also, they evaluate new treatment guidelines and information concerning other important points about the disorders studied. The large amount of information provided by the protocols and the corresponding sub analyses make understanding them a difficult task. In this work, we intend to emphasize and summarize the essential points and conclusions of each of the protocols already published by the DRCR.net, highlighting their importance in clinical practice, which will result in better decisions for the individualized treatment of diabetic patients.


REFERENCES

  1. Diabetic Retinopathy Clinical Research Network. Comparison of the modified Early Treatment Diabetic Retinopathy Study and mild macular grid laser photocoagulation strategies for diabetic macular edema. Arch Ophthalmol. 2007;125(4):469-8.

  2. Diabetic Retinopathy Clinical Research Network. The Relationship between OCT-measured Central Retinal Thickness and Visual Acuity in Diabetic Macular Edema. Ophthalmology. 2007;114(3):525-36.

  3. Diabetic Retinopathy Clinical Research Network. Comparison of Time- Domain OCT and Fundus Photographic Assessments of Retinal Thickening in Eyes with Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2008;49(5):1745-52.

  4. Diabetic Retinopathy Clinical Research Network. Association of the extent of diabetic macular edema as assessed by optical coherence tomography with visual acuity and retina outcome variables. Retina. 2009; 29:300-5.

  5. Diabetic Retinopathy Clinical Research Network. Association of Fluorescein Angiographic Features with Visual Acuity and with Optical Coherence Tomographic and Stereoscopic Color Fundus Photographic Features of Diabetic Macular Edema in a Randomized Clinical Trial. Retina. 2010;30(10):1627-37.

  6. Diabetic Retinopathy Clinical Research Network. A Randomized Trial Comparing Intravitreal Triamcinolone Acetonide and Focal/Grid Photocoagulation for Diabetic Macular Edema. Ophthalmology. 2008;115(9): 1447-9.

  7. Diabetic Retinopathy Clinical Research Network. Three-year Follow Up of a Randomized Trial Comparing Focal/Grid Photocoagulation and Intravitreal Triamcinolone for Diabetic Macular Edema. Arch Ophthalmol. 2009;127(3):245-51.

  8. Diabetic Retinopathy Clinical Research Network. Diurnal Variation in Retinal Thickening Measurement by OCT in Center-involved Diabetic Macular Edema. Arch Ophthalmol. 2006;124(12):1701-7.

  9. Diabetic Retinopathy Clinical Research Network. Vitrectomy Outcomes in Eyes with Diabetic Macular Edema and Vitreomacular Traction. Ophthalmology. 2010;117(6):1087-93.e3.

  10. Diabetic Retinopathy Clinical Research Network. Factors associated with visual acuity outcomes after vitrectomy for diabetic macular edema. Retina. 2010:30:1488-95.

  11. Diabetic Retinopathy Clinical Research Network. A Randomized Trial of Peribulbar Triamcinolone Acetonide with and without Focal Photocoagulation for Mild Diabetic Macular Edema: A Pilot Study. Ophthalmology. 2007;114(6):1190-6.

  12. Diabetic Retinopathy Clinical Research Network. An Observational Study of the Development of Diabetic Macular Edema Following Panretinal (Scatter) Photocoagulation (PRP) Given in 1 or 4 Sittings. Arch Ophthalmol. 2009;127(2):132-40.

  13. Bressler NM, Edwards AR, Antoszyk AN, Beck RW, Browning DJ, Ciardella AP, et al. Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy. Am J Ophthalmol. 2008;145:894-901.

  14. Diabetic Retinopathy Clinical Research Network. Observational study of subclinical diabetic macular edema. Eye. 2012;26:833-40.

  15. Diabetic Retinopathy Clinical Research Network. A Phase 2 Randomized Clinical Trial of Intravitreal Bevacizumab for Diabetic Macular Edema. Ophthalmology. 2007;114(10):1860-7.

  16. The Diabetic Retinopathy Clinical Research Network. Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema. Ophthalmology. 2010;117(6):1064-77.e35.

  17. The Diabetic Retinopathy Clinical Research Network. Expanded 2-Year Follow-up of Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema. Ophthalmology. 2011;118(4):609-14.

  18. Diabetic Retinopathy Clinical Research Network. Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt vs Deferred Laser Treatment: 3-year Randomized Trial Results. Ophthalmology. 2012;119(11): 2312-8.

  19. Diabetic Retinopathy Clinical Research Network. Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt versus Deferred Laser Treatment: 5-Year Randomized Trial Results. Ophthalmology. 2015;122(2): 375-81.

  20. Diabetic Retinopathy Clinical Research Network. Randomized Trial Evaluating Short-Term Effects of Intravitreal Ranibizumab or Triamcinolone Acetonide on Macular Edema Following Focal/Grid Laser for Diabetic Macular Edema in Eyes Also Receiving Panretinal Photocoagulation. Retina. 2011;31(6):1009-27.

  21. Diabetic Retinopathy Clinical Research Network. The Course of Response to Focal/Grid Photocoagulation for Diabetic Macular Edema. Retina. 2009;29(10):1436-43.

  22. Diabetic Retinopathy Clinical Research Network. Evaluation of Visual Acuity Measurements After Autorefraction vs Manual Refraction in Eyes With and Without Diabetic Macular Edema. Arch Ophthalmol. 2012; 130(4):470-9.

  23. Dagogo-Jack S, Funnell MM, Davidson J. Barriers to achieving optimal glycemic control in a multi-ethnic society: a US focus. Curr Diabetes Rev. 2006;2(3):285-93.

  24. Davis MD, Fisher MR, Gangnon RE, Barton F, Aiello LM, Chew EY, et al. Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss: ETDRS report #18. Invest Ophthalmol Vis Sci. 1998;39:233-52.

  25. Stratton IM, Kohner EM, Aldington SJ, Turner RC, Holman RR, Manley SE, et al. UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis. Diabetologia. 2001;44(2):156-63.

  26. The Diabetes Control and Complication Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complication in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-86.

  27. Diabetic Retinopathy Clinical Research Network Writing Committee. Cluster Randomized Trial Assessing the Effect on Diabetes Control of Personalized Diabetes Complication Risk Assessment during Ophthalmology Exams. JAMA Ophthalmol. 2015;133(8):888-96.

  28. Diabetic Retinopathy Clincical Research Network. Randomized clinical trial evaluating intravitreal ranibizumab or saline for vitreous hemorrhage from proliferative diabetic retinopathy. JAMA Ophthalmol. 2013; 131(3):283-93.

  29. Diabetic Retinopathy Clinical Research Network. Evaluation of Results 1 Year Following Short-term Use of Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy, JAMA Ophthalmol. 2014; 132(7):889-90.

  30. Diabetic Retinopathy Clinical Research Network. Retinal Thickness in People with Diabetes and Minimal or No Diabetic Retinopathy: Heidelberg Spectralis Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2012;53:8154-61.

  31. The Diabetic Retinopathy Clinical Research Network. Reproducibility of Spectral Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time Domain Metrics in Diabetic Macular Edema. JAMA Ophthalmol. 2014;132(9):1113-22.

  32. Bressler SB, Edwards AR, Andreoli AM, Edwards PA, Glassman AR, Jaffe GJ, et al. Reproducibility of Optovue RTVue optical coherence tomography retinal thickness measurements and conversion to equivalent Zeiss stratus metrics in diabetic macular edema. Tran Vis Sci Tech. 2015;4(1):5.

  33. Diabetic Retinopathy Clinical Research Network Authors/Writing Committee. Pilot Study of Individuals With Diabetic Macular Edema Undergoing Cataract Surgery. JAMA Ophthalmol. 2014;132(2):224-6.

  34. Diabetic Retinopathy Clinical Research Network Authors/Writing Committee, Baker CW, Almukhtar T, et al. Macular Edema After Cataract Surgery in Eyes Without Preoperative Central-Involved Diabetic Macular Edema. JAMA Ophthalmol. 2013;131(7):870-9.

  35. Friedman SM, Almukhtar TH, Baker CW, Glassman AR, Elman MJ, Bressler NM; Diabetic Retinopathy Clinical Research Network. Topical nepafenec in eyes with non-central diabetic macular edema. Retina. 2015;35(5):944-56.

  36. Diabetic Retinopathy Clinical Research Network. Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial, JAMA Ophthalmol. 2015;314(20):2137-46.

  37. Diabetic Retinopathy Clinical Research Network. Cost-effectiveness of Intravitreous Ranibizumab Compared With Panretinal Photocoagulation for Proliferative Diabetic Retinopathy Secondary Analysis From a Diabetic Retinopathy Clinical Research Network Randomized Clinical Trial. JAMA Ophthalmol 2017;135(6):576-84.

  38. Diabetic Retinopathy Clinical Research Network. Five-Year Outcomes of Panretinal Photocoagulation vs Introus Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. JAMA Ophthalmol. 2018;136(10):1138-48.

  39. Diabetic Retinopathy Clinical Research Network; Wells JA, Glassman AR, Ayala AR, Jampol LM, Aiello LP, Antoszyk AN, et al. Aflibercept, bevaczumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372:1193-203.

  40. Diabetic Retinopathy Clinical Research Network Aflibercept. Bevacizumab, or Ranibizumab for Diabetic Macular Edema Two-Year Results from a Comparative Effectiveness Randomized Clinical Trial. Ophthalmology. 2016;123(6):1351-9.

  41. Diabetic Retinopathy Clinical Research Network. Effect of Adding Dexamethasone to Continued Ranibizumab, Treatment in Patients With Persistent Diabetic Macular Edema. JAMA Ophthalmol. 2018;136(1):29-38.




2020     |     www.medigraphic.com