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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2018, Number 3

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Alerg Asma Inmunol Pediatr 2018; 27 (3)

Refractory Kawasaki disease

Moribe QIC, Cabrera VMA, Lee Ng R, Yamazaki NMA

Language: Spanish
References: 37
Page: 94-102
PDF size: 210.16 Kb.


ABSTRACT

Kawasaki disease is the second most frequent acute vasculitis in the pediatric age, GGIV is the established treatment for the disease. Worldwide, it is established that 10-20% of patients that are treated with GGIV at 2 g/kg/dose do not respond to treatment, this group of patients is a therapeutic challenge for physicians, there are different therapeutic measures that we can use, such as: 2nd dose of GGIV, corticosteroids in high doses, some monoclonal antibodies such as infliximab, anakinra, etanercept, tocilizumab, rituximab and others such as methotrexate and plasmapheresis. In the search to identify patients at high risk for refractary treatment, groups of experts have created diagnostic tools applicable at the time of diagnosis in order to modify the therapeutic measures and reduce the risk of treatment resistance to GGIV, such as scales of Kobayashi, Sano and Egami, among others.


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