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2018, Number 2

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Rev Med MD 2018; 9.10 (2)

Non‐alcoholic fatty liver disease Where we are and where are we going?

Velarde-Ruiz VJA, Mercado-Jáuregui LA, Bocaletti-García MM, Pinzón-Flores ÓE, Barrientos-Ávalos JR

Language: Spanish
References: 72
Page: 155-163
PDF size: 645.12 Kb.


ABSTRACT

Nowadays liver diseases are constantly increasing, being the metabolic syndrome, or some of its components, directly related. Nonalcoholic fatty liver disease has a broad spectrum that goes from simple steatosis to steatohepatitis, fibrosis, cirrhosis and in some cases hepatocellular carcinoma. It is predicted that nonalcoholic fatty liver disease will become in a few years one of the main causes of cirrhosis and a leading cause of liver transplant. In Mexico, the reported prevalence is highly variable. It is important to acknowledge the risk factors associated with this disease, such as diabetes, obesity, genetic susceptibility and other emergent associations (polycystic ovarian syndrome, hypothyroidism, sleep obstructive apnea, hypopituitarism, and hypogonadism). Liver function tests can be considered for initial assessment of the disease; ultrasound can be a feasible complementary test. There are noninvasive methods for the evaluation of fibrosis in these patients. The biggest impact of nonalcoholic fatty liver disease lies on the high cardiovascular associated mortality. The foundations of treatment are diet and exercise. The drugs with more evidence are still pioglitazone and vitamin E for certain clinical scenarios. There are emergent pharmacological and surgical therapies that require more evaluation studies in order to be used.


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