2018, Number 6
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Acta Pediatr Mex 2018; 39 (6)
Methemoglobinemia by phenazopyridine: a case report with diagnostic approach
Pérez-Tuñón JG, Martiñón-Ríos R, Figueroa-Rivera M
Language: Spanish
References: 30
Page: 355-360
PDF size: 321.40 Kb.
ABSTRACT
Introduction: Acquired methemoglobinemia is a disorder in which hemoglobin is
oxidized by an external agent, blocking transport and delivery of oxygen to tissues. One
of the oxidizing agents is phenazopyridine hydrochloride, an aniline with analgesic
effect used to treat urinary tract pain.
Case Report: We present the case of a 12-year-old female patient who swallowed
250 mg of amitriptyline, 1.8 gr of phenazopyridine and 14.5 mg of clonazepam on
a suicide attempt, developing metahemoglobinemia that required administration of
methylene blue twice.
Conclusions: Methemoglobinemia is an underdiagnosed condition that can lead to
serious complications and even death. It is diagnosed by co-oximetry. When this is
not available, in addition to the clinical data, the saturation gap and the presence of
"chocolate" blood should be evaluated.
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