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Órgano Oficial del Instituto Nacional de Pediatría

2018, Number S1

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Acta Pediatr Mex 2018; 39 (S1)

Congenital hypothyroidism birth prevalence:

Hinojosa-Trejo MA, Vela-Amieva M, Ibarra-González I, de Cosío-Farias AP, Herrera-Pérez LA, Caamal-Parra G, Bolaños-Córdova LE, García-Flores EP

Language: Spanish
References: 32
Page: 5-13
PDF size: 400.20 Kb.


ABSTRACT

Introduction: Congenital hypothyroidism is the most common preventable cause of intellectual disability. In Mexico newborn screening (NBS) of this disease is mandatory. Congenital hypothyroidism birth prevalence has been previously described in Mexico, however, these studies date from more than 10 years ago.
Objective: To present updated information on the congenital hypothyroidism birth prevalence from the NBS Program of the Ministry of Health and to compare it with those previously reported in Mexico.
Materials and Methods: Retrospective study of newborns screened in the medical units of the Ministry of Health from January 1, 2017 to May 31, 2018. Thyroid stimulating hormone (TSH) was quantified in neonatal blood. A review from the literature was made searching the congenital hypothyroidism birth prevalence, considering the publications of the year 2000 to date.
Results: In 1,267,122 samples suitable for biochemical analysis, we found 3.337 newborns with TSH › 10 m/mL. 923 cases were confirmed and from them 564 (61.1%) were girls. The congenital hypothyroidism birth prevalence was 7.3 per 10,000 screened newborns. From the bibliographic review, only two studies were found with national data disaggregated by federative entity, with a national prevalence of 4.1 and 4.3 x 10,000 newborns.
Conclusion: Congenital hypothyroidism birth prevalence in Mexico was 7.3 x each 10,000 newborns screened in the Ministry of Health, which means that one in 1373 has this condition being, the girls the most affected ones. CH birth prevalence in has increased 1.8 times in the last 14 years.


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