Raya-Farías A, Carranza-Madrigal J, Campos-Pérez Y, Cortés-Rojo C, Sánchez-Pérez TA

Language: Spanish
References: 26
Page: 840-847
PDF size: 547.82 Kb.

ABSTRACT

Objective: To determinate if the ingestion of avocado in patients with metabolic syndrome diminishes endothelial dysfunction, oxidative stress and inflammation after ingesting hamburger meat.
Material and Method: An experimental, longitudinal, randomized, prospective, crossed, open but blinded for outcomes evaluators trial was done from June to August 2018 in patients with metabolic syndrome in agreement to NCEP criteria. These patients were evaluated for endothelial function, inflammatory state and oxidative stress after two treatments: a hamburger meal and a hamburger meal plus avocado.
Results: Fourteen patients with metabolic syndrome were included (11 men and 3 women). When ingesting hamburger meat, NO levels were raised compared when adding avocado that blunted this effect (p ‹ 0.05). Hamburger decreased lipoperoxidation, effect that was inhibited by adding avocado (p ‹ 0.05). The oxidative reactive species elevated their monocyte expression after hamburger ingestion; this effect was also inhibited by adding avocado (p ‹ 0.05). No differences were found in the levels of adhesive molecules CD11b, CD18 in granulocytes and monocytes.
Conclusions: In an acute manner, avocado blocks the reduction of nitric oxide, diminishes formation of oxygen reactive species and blocks reduction of lipid peroxidation concentrations caused by a hamburger.

REFERENCES

1. Lucas-Luciardi H, Berman SG, Chain S y col. Determinación de marcadores séricos de trombosis e inflamación en sujetos con intolerancia a la glucosa: evidencia de un estado protrombótico. Archivo de Cardiología de México 2012;1-6.

2. Badimon L, Martínez-González J. Endotelio en la protección vascular: nuevos conocimientos. Rev Esp Cardiol 2002;17-26.

3. Li Z, Wong A, Henning S, Zhang Y, et al. Hass avocado modulates postprandial vascular reactivity and postprandial inflammatory responses to a hamburger meal in healthy volunteers. Food Funct 2013;384-391.

4. Jablonska E, Kiersnowska-Rogowska B, Ratajczak W, et al. Reactive oxygen and nitrogen species in the course of BCLL. Adv Med Sci 2007;154-158.

5. Miranda K, Espey M, Wink D. A rapid simple spectrophotometric method for simultanaous detection of nitrate and nitrite. Biol Chem 2007;62-71.

6. Carranza-Madrigal J, Alvizouri-Muñóz M, Herrera-Abarca JE, Chávez-Carbajal F. Efectos del aguacate como fuente de ácidos grasos monoinsaturados en lípidos, metabolismo de la glucosa y reología en pacientes con diabetes tipo 2. Med Int Mex 2008;24(4)267:72.

7. Alvizouri-Muñoz M, Carranza-Madrigal J, Herrera-Abarca JE, Chávez-Carvajal F, Amezcua-Gastelum JL. Effects of avocado as a source of monounsaturated fatty acids on plasma lipid levels. Arch Med Res 1992;23(4):163-7.

8. Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr 2005;969-972.

9. Gower M, Huaizhu Wu R, Foster GA, et al. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to VCAM-1. Arterioscler Thromb Vasc Biol 2011;31(1).

10. Badimóna L, Martínez-González J. Disfunción endotelial. Rev Esp Cardiol 2006;21-30.

11. Casino P, Crescence M, Quyyumi A, Hoeg J, Panza J. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 1993;2541-2547.

12. Liao J, Shin W, Lee W, Clark S. Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 1995;319-324.

13. Li L, Li J. Link between oxidative stress and insulin resistance. Clin Med Sci J 2007;254-259.

14. Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab 2000;2572-2575.

15. Dvoráková-Lorenzová A, et al. The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin. Metabolism 2006;359-365.

16. Aguilar-Salinas C, et al. High prevalence of metabolic syndrome in Mexico. Arch Med Rea 2004;76-81.

17. Badimon L. Estatinas y función endotelial. Rev Esp Cardiol 2003;25-40.

18. Schlaich JS, et al. Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients. A randomized, placebo-controlled, double-blind study. Circulation 1998;211-216.

19. Nuñez-Cortés J, Patogenia de la aterosclerosis. Posibilidades actual y futura del tratamiento hipolipemiante. Rev Clin Esp 2002;17-28.

20. Ridker P, Hennekens C, et al. Plasma concentration of soluble intercellular adhesion molecule 1 and risk of future myocardial infarction in apparently healthy men. Lancet 1998;88-92.

21. Smalley D, et al. Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. Arterioscler Thromb Vasc Biol 1996;585.590.

22. Sohar R. The free radical hipótesis of aging: an appraisal of the current status. Aging Clin Exp Res 1999;5-17.

23. Wei Y, Chen K, Whaley-Connell A, et al. Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species. Am J Physiol Regul Integr Com Physiol 2007;19.

24. Williams M, Sutherland W, McCormick M, et al. Impaired endothelial function following a meal rich in used cooking fat. J Am Coll Cardiol 1999;1050-1055.

25. Xydakis A, Case C, Jones P, et al. Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction. J Clin Endocrinol Metab 2004;697-703.

26. Zeiher A, Drexler H, Wollschlager H, Just H. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;391-401.